<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03950

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSVTNIRVLDGFSNIYWRIYTEDPNITNLPGEAPANGFTILKHLSRLKDLELRLRNSDCLVSSYPRRLGLWVFSATPEFESVRSLRSDESKGEQSRLVVGSSTLKVSASGSVTPRELVKNLSTDPQTVGGSTGSQRPQGTPTPTRRVDSYSSSVAIYAAFISAITGSLNLQLIRRSSAIPLGSRTLFTVIERDYYETSRIVNDDPSSISALTTLQVQLTSAGKLTVSLQTTSQPGIAPLCRLGESLSDIRDVAPGADIWLSPSGSVARLVSINPGPPNASSPLPHTGSIGIDSLGAAGRKQWKANVLEWLRNFGLLIDPVDETAWVEVEVWEPFYSRLAGETLRLNEDNSSTLPLKRVLWPAVYCFRRTKSAFPGSSQWMESACPVVSDPLDFAENWRVMEKPKQDETSPKPPSSHSEQQSRNPEPSAATTDILEGIESLSRASEYPDLQTVSLVYPTPPDGAAAMGLNLTGPSDTFAEEPDLVPSLLQNQSKSKYYEQLTTKDRSEADPSAGFGPLGGLAVGSGLYDTNEDDDLFGDMDEKDFGTKGITDADFNFFDDPSFAAMDTDVPADDAQDVPDMVNLEVTEAHPTISDDALLEDFAAQKTPAEILEVAQASPDEVTPEVQPEHMDAEETTVAASPHTEQNQTISPPLSPVEIKRILLPEPEGDNHIPTKGSRKQSYYNPVAFKPNMSAWDQKYGADGKFRFTTAGPSGSKVYTNSDIPTVGMPRRNKKYPTAGAGLMSLDGHASPSSEGQHLQAVSDSSSDTSDDSDGSALESDAPPLLSRKRKRARSNSVGSPAISQVKSLGEAEQEIPVHRPEHSIFLGNLLSTFSDWSMTGYFSLTENRLFPVLTRKDMQIHIAQLFVDQITQSSLDHKLDGGFCLSDLDTKAYSVQTFFEEEGILGGIERLDLNSWISLQDNEQASPAPNGAVSRQSSQRKEMGKGSITKLSPPHLRVRRGKEYLEALPPAISFWETFGLEPADGPKDISAYCIHPQIAGDAADVFLERLGLLYASCNLGKHVRGCRSSAFERGLYSWDVGSLETAHILPAMQSLKVICEELGTALLKGSPSNDSLVIYIINPFAHASALVDICSAFWCLFQKYIADTGKQQARQLNEVVLQIIPISFIMSTGSVVVPLQAQYLNLALEIYSRCPPKALQSSLVNCAPPVLLAEPLPRTISFRLASEKTSPLQEGKCLHIAYSKSQDQRWIGVAWSDNSGALQRTISYNLRYRNASAVRSISDVRSEIWVATKDILDRIQARWKVFVVSTEPVDQDEVDAWTSFIEQYNKANSIPLELTILSVNTAPDLHLEPPFLPMSMSIFNPQTSSTPVATPNASGNVFSPDQSGTAPTPPSGGNAPANAPTPTEPTLEAETESVLTDICDDSWGVILSHRLNNSPHLTEYRPALASGYLLRRKGDTDGDGVYAMTLNLIYTQRPSSCEAILRETLGMYRDLGTLARARGTRTVQRNTLPWHIATAVRAQEMLSHVL
Length1495
PositionKinase
OrganismAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.338
Instability index55.22
Isoelectric point4.98
Molecular weight163065.83
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03950
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     208.51|      34|      34|     754|     787|       1
---------------------------------------------------------------------------
  418-  444 (25.03/ 8.11)	..PS..SHSEQQ..SRNPEPSAATTDIL...E..G..IES...
  446-  478 (32.76/13.07)	...SraSEYPDL..QTVSLVYPTPPDGA...A..AMGLNLTGP
  513-  548 (30.65/11.71)	ADPS..AGFGPLggLAVGSGLYDTNEDD...DlfGDMDEKD..
  550-  575 (30.44/11.58)	........GT....KGITDADFNFFDDP...S..FAAMDTDVP
  581-  613 (34.32/14.06)	DVP....DMVNL..E.VTEAHPTISDDAlleD..FAAQKTPA.
  754-  787 (55.31/27.52)	ASPS..SEGQHL..QAVSDSSSDTSDDS...D..GSALESDAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      14|      16|    1339|    1354|       2
---------------------------------------------------------------------------
 1339- 1354 (21.67/16.79)	TPNASGNvfSPDQSGT
 1357- 1370 (26.18/13.35)	TPPSGGN..APANAPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.06|      14|      15|     945|     959|       3
---------------------------------------------------------------------------
  945-  959 (21.47/16.90)	RKEMGKGSITKLsPP
  962-  975 (25.58/15.16)	RVRRGKEYLEAL.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.27|      26|      34|     672|     704|       4
---------------------------------------------------------------------------
  672-  697 (50.10/28.66)	EGDNHIPTKG.SRKQSYYNPVAFKPNM
  707-  725 (18.25/16.00)	DGKFRFTTAGpSGSKVYTN........
  727-  748 (27.92/12.93)	....DIPTVGmPRRNKKY.PTAGAGLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.04|      14|      34|      79|      93|       5
---------------------------------------------------------------------------
   79-   93 (19.82/18.32)	SATPEfESVRSLRSD
  116-  129 (24.22/15.96)	SVTPR.ELVKNLSTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.40|      13|      17|     228|     240|       6
---------------------------------------------------------------------------
  228-  240 (22.22/14.72)	KLTVSLQTTSQ..PG
  246-  260 (18.18/10.36)	RLGESLSDIRDvaPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      16|      17|    1255|    1271|       7
---------------------------------------------------------------------------
 1255- 1271 (23.07/19.10)	VATKDI.LDRIQArWKVF
 1273- 1289 (24.03/14.01)	VSTEPVdQDEVDA.WTSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.27|      14|      17|    1139|    1152|       8
---------------------------------------------------------------------------
 1139- 1152 (23.81/12.88)	SVVVP..LQAQYLNLA
 1157- 1172 (22.46/11.73)	SRCPPkaLQSSLVNCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.21|      14|      21|     618|     632|       9
---------------------------------------------------------------------------
  618-  632 (21.66/15.52)	VAqASP.....DEVTPEVQP
  642-  660 (20.55/ 9.19)	VA.ASPhteqnQTISPPLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.14|      10|      21|    1013|    1025|      10
---------------------------------------------------------------------------
 1013- 1025 ( 8.18/16.14)	ERlGlLYaSCNLG
 1037- 1046 (21.96/12.52)	ER.G.LY.SWDVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.71|      25|     286|      50|      76|      13
---------------------------------------------------------------------------
   50-   76 (38.08/37.73)	SRLKDLELRLrNSDClVSSYPRRLGLW
  341-  365 (44.63/32.48)	SRLAGETLRL.NEDN.SSTLPLKRVLW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03950 with Med13 domain of Kingdom Fungi
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