<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03944

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSDSFNLPLRPLTEKRERPDPLPVEIAQINAQYGSFRDVTEDSLRAKIEADKNKDPWFDEEENDNASADEDTTERLDQLYKRRAAITQFALQAHMEAMFALDFVSLLLSKHTPRQAEMSMSAYLKQVAPLGSLNSEIVNPPPKPESAARDTKNVSRGWRLQNFNSAASKLLDSATRLEAEVASETKYWDEVLAVKEKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLAALRRTNDGSLILDKGLIPLKARTVRVRVRSCGQITGCSKNRPASDDAESIESRILQARDTVYEEELFHELVREARILGSQGVTTRQNLVQFPVSEEQEVLLDLIDDDQMSPEDDVVSSNEHAVVADALAHAIRILLAYAHRQNLHRRTQLPTPLTPKRRQTPEYQLLRPVMAYLQHSSHVRWLESLLNDMNQILKSAGITCDFTATPFSSLSLRRTSNGLPKVEALVQEFLLPYESTFSAQLVTPQSSFRVKVRTNATTPPLGTHYEISVNMPQYPDVRPPNRIGLQDEAASILTHFVLLDILTAITHAKGSSVKGIKQETGRLLTWQAAYPHNGELLALSSTGQHKKMKVSLSRHELTVQVYSVRGIDGFGKPAVDKTPAMRSQTWKSDGSPDQHNLMDFIAEVSKE
Length638
PositionHead
OrganismAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.479
Instability index49.65
Isoelectric point6.50
Molecular weight71673.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03944
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.02|      20|      32|     293|     312|       2
---------------------------------------------------------------------------
  293-  312 (31.50/20.17)	EEELFHELVREARILGSQGV
  326-  345 (32.52/21.05)	EQEVLLDLIDDDQMSPEDDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.20|      11|      30|     515|     525|       3
---------------------------------------------------------------------------
  515-  525 (17.70/12.37)	GLQDEAASILT
  546-  556 (18.51/13.30)	GIKQETGRLLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.66|      21|      32|     132|     152|       4
---------------------------------------------------------------------------
  132-  152 (36.03/20.07)	SLNSEIVNPPPKPES.AARDTK
  165-  186 (26.63/13.09)	SAASKLLDSATRLEAeVASETK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.01|      12|      35|     433|     444|       5
---------------------------------------------------------------------------
  433-  444 (21.89/13.50)	FTA...TPFSSLSLR
  468-  482 (17.12/ 9.02)	FSAqlvTPQSSFRVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03944 with Med17 domain of Kingdom Fungi
Unable to open file!