<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03942

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDNTKIGGAGQGSAIHDSRNGMPSLTPNINRTSAFGDSHAGRVHINGMTKNAVDPSQAEDASTVNVISTKSMELPSLPHITQGFFPFSKLISRSVQQSWNDLSDLITEMADIKVSPQEQNSLQLPASGKSFGNQSPENIRKKARILDFAHSKRAEFIKLLVLSQWSRQAADVSKLIDLQNFIRTRHQAYMGALQGIGDMKRDLVQAQVANPDLTTALEVLSKGKVSSMSDLGYKPPRSLTGKDTLKRLQKINRIISVRLALYDSVPRAFHSYSIHDGRVTFFVPNEFELDLSIGQEDESSQLYFVDIRFLFNPSSPILKGRIFNEFDVKINDALRNDGLSGCFDLLHSLVLTNKINILFKQAMELARGLWYDVLRVELLHRTLVVHYWTQKAGAKSWLEIGIKSGRICGENDSYSHPNLGLRWIRDGQEVDSEEIEFNTESLSMECILRSVIALHISHILSSAYCIISESLLYSAGRLSLQAQLARTEPGDCGLTIQLTESRHLSVSIEPMSGASIISATPSAQERLDNDRSSDKSSAEHIVARVARLRCMAAIDEIESNVKMLGFETVNPRSLKIDFRRMFPSNVLRFSFFWHHLWERNWIVAATSSMDGDNWWVVQLQKTTTTESHSVFDASTHISSTLRSAQAISGSFFHVSQNIGYPSFADLGHYLSGILAVHTNARYLADLQSVDFYPPLQRLVIEPNLQVPEIFMRYEAANIPEAFRIALPSGLKSRVRTKGTIRLAFHGIDPCKKVATIVAYGNLLIPIKAFSALNSTWDHSLVFQKRGTGFAIRLLAPPGRPVIPKLIENLQRLDCVLSIFECLQRKKMEPRSLSLSHVTFAYGPEKDLLATLNIETSMPPSSMELDPIFLASRTKSLFHLRLGLSFEFPNPHRRIQKSIESTLNHSTTDAVLDTVAELLLLTLPLMRALDQILMNPSNKQPLRVQVTVRNAKTFQIHYPGQSFRFQLVATHHLGHMVWILKELSSPKEGSSQDQLKLKLRERLYNSKGDGWRGLGNGVVAETGKVGNLLTELDKCFEASSAPDLTPEVKANGSKSFSQQSTAENGNLDGTLSESATLIPAPNATSTRHKTGDTTQNADIIMID
Length1102
PositionTail
OrganismAspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index50.86
Isoelectric point8.64
Molecular weight122746.68
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     332.63|     124|     373|     427|     608|       1
---------------------------------------------------------------------------
   71-  135 (87.26/38.54)	SME..LPSLP..HITQGFFPFSKLISRSVQQSWNDLS...DLI.TEMADIKVSPQEQNSLQLPASGKSFGNQS.................................................................................................
  443-  608 (177.09/233.86)	SMEciLRSVIalHISHILSSAYCIISESLLYSAGRLSlqaQLArTEPGDCGLTIQLTESRHLSVSIEPMSGASiisatpsaqerldndrssdkssaehivarvarLRCMAAIDEI...ESNVKMLGFEtVNPRSLKiDFRRMFPSNVLRFSFF.WHHLWERNWIVAATSS
  922-  984 (68.28/25.50)	.........................................................................................................LPLMRALDQIlmnPSNKQPLRVQ.VTVRNAK.TFQIHYPGQSFRFQLVaTHHLGHMVWILKELSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.55|      10|      16|     265|     274|       2
---------------------------------------------------------------------------
  265-  274 (19.52/12.17)	VPRAFH.SYSI
  283-  293 (14.03/ 6.66)	VPNEFElDLSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.90|      12|      15|     154|     168|       7
---------------------------------------------------------------------------
  154-  165 (20.40/17.59)	AEFIKLLVLSQW
  170-  181 (19.50/ 6.35)	ADVSKLIDLQNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.19|      17|     619|       9|      25|       8
---------------------------------------------------------------------------
    9-   25 (33.63/21.39)	AGQGSAIHDSRN.GMPSL
  646-  663 (29.55/17.84)	AISGSFFHVSQNiGYPSF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03942 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MDNTKIGGAGQGSAIHDSRNGMPSLTPNINRTSAFGDSHAGRVHINGMTKNAVDPSQAEDASTVN
2) PEVKANGSKSFSQQSTAENGNLDGTLSESATLIPAPNATSTRHKTGDTTQNADIIM
1
1045
65
1100










Molecular Recognition Features






MoRF SequenceStartStop




1) LKLKLRERLYN
994
1004