Description | Mediator of RNA polymerase II transcription subunit 13 |
Sequence | MVESDEDPPYGAIPIPGLSSNILRIANVGEIKYRVYDSTSKLRLRKAEWMLRTEQGALCSVEREELWVFANTLGKTPTGEAVWPEIDVHEHELQETSSGAFIIRPQHLSPHTQTHIPPTTHTAFLNSLKGLLSHQLTQSHGFVPLGSSLLYPTAGLGVVNARRWILCGLEARVLGDGSVLVALNGEEKGRWLRCLCDDRRGYIHPVEAHERCWLAPTGRECKVLSHIPIADRYWPEVKVLVDGLEKVVPARHVFTDYEPRTPPKEDLTIWKKEDAIMDALRMCREFKLGMESGEKNGDVEEEMVGPKGRKEGAVGVVYPTPPDALLHLPGVHSIQQQQIQTQAQISPQPAPTPAASTASVEAPNPKDVKQTVSKSKKENSFDFWDAKFDEPDLDEDDLWGEDDDGVGGFGQGVTDADWDFFDKPANEPYAEPVQDQVMEGIEDTRDAEIGEAHVLPGPPGDKRGWDGDIEERMEVDQQPARVQQREAQYPAGILQYDSPAATPIHPKDVRVLTPQPKSLGILGAAAEVNSEPRGKENKVLVPKGFEAVKFSAKVEKNDKKYGVGGRYYAPPKSSSSSSSDTTSYDDDEDEPQPVQRKRPWEEAFEKVLVKPPPSEVAETPEEVDPETELVGMAWEWDSNHLFRDGFMGDPEPQRVISEDKAGIVQVFVEHVLFGYEVPPLPSPDDGFIPKGNTLCKALRSAVGEVEGTEVLTARGLSEIADPVPPESTVGGGGGKTGFKPKAVPRSARKNSVVDGDVTMEDAPLGEGSKDLFLIPPPKLTTMFKEKKIEYSVLAQRYWTTIGLAPLGGPRNVSAIIVYPGSEAMSYAADSFLNRMRGTWELNKLGKHRAFMGGSKVAVNLGGSEKEGEWEGAWRMMNAKILGVGRQLRSSAAQDSGAHFVVYIVNPFNNPAATAALCGSFAQMEKLYQSGGDKMPRTSVSLLPMRMLVGDEWGCRGKLNQREYLQMALALYERLGFTQQKALDVFSKSPVAKPWVLAHPVPTQINFRLSTHRSPSILHENMMLHVAYAVSEDGRWLCVAWCNEHGEYTFADAFRINLEDPGAKGWHEAYQKAWTKTMEIISVMKIHWRVVVAKHGFMTTDEMSFWLRLSTANEGASPYSLTLASVDVDSNLALSTFGDQPLRLDDLFDPEDFSEYKSVDQTLKEGLGYKDDETWGMILNYRVPWPCEGESEGAMKYPAMSAYLLRRAEGDVCEGVQVHLLYARDQLRPLMKDILGQYRNLAVLRRYSNSRQSVPWHIWAVQRLQEGFKKELGVGPKITPENPGAENSSSLSKAKVRPSKRESQK |
Length | 1304 |
Position | Kinase |
Organism | Saitoella complicata (strain BCRC 22490 / CBS 7301 / JCM 7358 / NBRC 10748 / NRRL Y-17804) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Taphrinomycotina incertae sedis> Saitoella. |
Aromaticity | 0.08 |
Grand average of hydropathy | -0.493 |
Instability index | 42.61 |
Isoelectric point | 5.36 |
Molecular weight | 144810.03 |
Publications | PubMed=21914972 PubMed=24646756 |
Annotated function |
Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.
ECO:0000256 RuleBase:RU364134 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP03935 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 116.81| 35| 498| 672| 710| 1 --------------------------------------------------------------------------- 675- 709 (63.57/41.08) YEVP.PLPSPDDGFIPKGNTLCKALRSAVGEV.EGTE 1180- 1216 (53.24/24.94) YRVPwPCEGESEGAMKYPAMSAYLLRRAEGDVcEGVQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 373.75| 122| 168| 234| 400| 3 --------------------------------------------------------------------------- 234- 303 (88.07/46.00) ............................................................................WPE.VKVLVDGLEK.VVPARHVFTD...YEPRTPPK......EDLTIW.KKEDAIMDALRMCREfklgMESGEK.............NGDVEEEM 333- 473 (163.73/123.63) SIQQQQIQTQAQI..SPQPAPTPAastasveapNPKDVKQTVSKSKkenSFDFWDA...KFDEPDLDEDDLWG......eDDDGVGGFGQgVTDADWDFFDkpaNEPYAEPV......Q.........DQVMEGIEDTRD....AEIGEAhvlpgppgdkrgwDGDIEERM 481- 589 (121.95/57.65) RVQQREAQYPAGIlqYDSPAATPI.........HPKDVRVLTPQPK...SLGILGAaaeVNSEPRGKENKVLVpkgFEA.VK.FSAKVEK.NDKKYGVGGR...Y..YAPPKssssssSDTTSYdDDED.......................................... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 201.47| 63| 704| 124| 189| 4 --------------------------------------------------------------------------- 124- 189 (98.20/65.62) FLNSLKGLLS.HQLTQSHGFvpLGSSLLYPTAGlGVVNARRW..ILCGLEARVLGDGSVLVALNGEEKG 831- 896 (103.26/59.30) FLNRMRGTWElNKLGKHRAF..MGGSKVAVNLG.GSEKEGEWegAWRMMNAKILGVGRQLRSSAAQDSG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 90.66| 26| 219| 1027| 1063| 5 --------------------------------------------------------------------------- 190- 218 (42.99/16.73) RWLrCL..CDDRRGYIHPvEAHeRCWLAPTG 1034- 1061 (47.66/29.28) RWL.CVawCNEHGEYTFA.DAF.RINLEDPG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 79.37| 24| 39| 758| 782| 8 --------------------------------------------------------------------------- 758- 782 (40.21/30.81) TMEDAPLGeGSKDL.FLIPPPKLTTM 800- 824 (39.16/24.79) TIGLAPLG.GPRNVsAIIVYPGSEAM --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DKKYGVGGRYYAPPKSS 2) FDFWDAKFDEPDLDEDDLWGE 3) SSSLSKAKVRPSKRESQK | 558 381 1287 | 574 401 1304 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab