<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03919

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFPAGAVTNFRMTEIYSTIHWKIYYIESHQLPSPGAGVLEDPSSALAIELESAILLIRDQGCLVDAIPGGNGLWVFSHNGEFDQLQPFSVLESDCSLTSLQIGAITFKQFHAEFTPLGYLIKRLMAEPQGTIFSPLSQQKFANTNEDCPINREIVTSSAFYKAFTSAIAGSLSLRATQLHGAIPLGKRALFTTSAPDEKLGQGINADPTLGPRSLLSTLNIEFSFKSLIISWRTIPQWGLQQLSTTAGADSISDVSLHEDIWLAPTGSLCRYIGADPGHSSGPQWDPSVGDYGEFEFPGGGNLLYLREWKRAVCVRLRMFGLGSVDPDTETWIEVEALNPFESRLGGTAGENRKSIAYKRFLWPARLCFKRSSEQCLALDKRAEYLDAATLDPLSLAEKWVTEMTTRTSPEDQMAVETHVAEGMQPEATGTTEKTSSSEIFASLARKIDFSDLSAGAVYPTPPGAVTGTGLVAAGSSDVLTLPGVSSLSHAHPQNTSRRSDVNISGAGCQSTSNSLPPVDITTTALEIGSGMYDTTADDDLFDELDGDFAPKQITEADFNFFDEPDFAAFPGSIDVSMGRVNTSLQNSHGAHDGDALDIAGTSHDAVERPAGSAEPEERKDSMRNREHRVVLVPPAVSSPKENVQADLPIESGNIISPTPVTPHQPLSPSIIRKILFSGNSGIPTTTSFDKHPTNRKARSGYEPLSFGEDLSLSDGKYELDGRFWFLPNAESDQMEMHPSDIPRVGIPEWRNEERRALPMEDSSRDRLKSGMQSSSDSSAESSEDDSEPETTPLDYSNRGLRVLSASRDNSQRFKDLDFTPSPLEPLTVNTEFSNTGMNANTLSFLRTLLFRAIDWTLDGYFTSTSGRFPVLLRRDDLIQVAQIVVDQVTQSSLSHVLERRTSIGLDQQNALPLSSTSKDSWYGKFSNFDIKRYTAIDVDTSIQGLRKDFRYLTVGSMSKLDPPHIRIHRGKGELEVLPPAIFFWEPFGFEPTQGQKDILAYCIYPESAEEGADAFLGRMGLLYSSANLGQHSRPQDSKGLIPWGLECTSIRDYTAIMNRLQTTCEHLGDVISCLPPGSENILVYIANPFPYEAAVVDICTAFLFLFRKYVSNFEKHTIRLNEVALQIIPLDFIASLTSLVVPSQQDYLHLAFEVYSRCPPKNRSSDLLGCAPPFTLAKPAPKIVPFKLTPDSGSPLAEKHSIHVAYSQSIDQRWVTAAWTDNLGRDQLTMTYCLRERGSTISRPASEIRADIWSVTRHIIGKSHAYWRVMVVKDEPLELDEAEAWVSMAQHHNQTKPTKIELTLLSVNPKPCLFFKLPPPPLQPSTLTGPTTSTPVSTPNPSMPSPDPSAAAPTPPPSSAEQAQTPIAQSLDPADSETILIDKTEETWSITLSHRVNISPSLANYHPALASGYLLRRRDGTSDTEGLASLCVNLIFTHSRIPSEMVLKDTLRVYRDLVTLARTKGIFHAQGDDVLPWHISTAVKGREFLGVVL
Length1495
PositionKinase
OrganismCoccidioides immitis (strain RS) (Valley fever fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
Aromaticity0.08
Grand average of hydropathy-0.289
Instability index45.76
Isoelectric point5.12
Molecular weight164274.85
Publications
PubMed=19717792
PubMed=20516208

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP03919
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     542.88|     140|     142|     685|     826|       1
---------------------------------------------------------------------------
  484-  668 (169.42/107.90)	.PGV..SSLSHaHPQNTSRRSdvnisgagcqstsnslppvditttALEIGSGMYDTTADDDLFdELD.......GDFAPKQITEADFNFFDEPDfaaFPgSID......VSMGRV....N..TSLQNSHGAHDGDALDIAGTSHDAVERPAGSAEPEERKDSMRNREHR.......VvlvppaVSSPKENVQ..ADLpiesgniisptPVTPhQPL
  684-  825 (239.28/162.31)	IPTT..TSFDK.HPTNRKARS........................GYEPLSFGEDLSLSDGKY.ELD.......GRFWFLPNAESDQMEMHPSD...IP.RVG......IPEWRN....EERRALPMEDSSRDRLKSGMQSSSDSSAESSEDDSEPETTPLDYSNRGLR.......V......LSASRDNSQrfKDL...........DFTP.SPL
  826-  961 (134.18/83.04)	EPLTvnTEFSN.TGMN..A............................NTLSFLRTLLFRAIDW.TLDgyftstsGRFPVLLR.RDDLIQVAQIV...VD.QVTqsslshVLERRTsiglDQQNALPLSSTSKDSW.YGKFSNFDIKRYTAID........VDTSIQGLRkdfryltV......GSMSK............................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.18|      14|      66|     196|     209|       2
---------------------------------------------------------------------------
  196-  209 (26.85/18.74)	APDEKLGQGINADP
  265-  278 (28.33/20.27)	APTGSLCRYIGADP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     573.83|     187|     981|     233|     445|       3
---------------------------------------------------------------------------
  233-  445 (291.24/179.63)	WRTiPQW....GLQQLSTT....AGADSISDVS..LHEDIWlaptgslcryigadpGHSSGpQWDPSVGDYGEFEFPGGGNLLYL...REWKRAVCVRLRMFglgSVDPDTETWIEVEAlNPFE.SRLGGTAGENRKSIAYKRFLWP.....ARLCFKRSSEQclALDKRAEYLDAATLDPL...SLAEKWVTEMTTRTSPEDQMA.VETHVAEGMqpeATGTTEKTSSSEIFASL
 1216- 1432 (282.59/146.17)	WVT.AAWtdnlGRDQLTMTyclrERGSTISRPAseIRADIW........svtrhiiGKSHA.YWRVMVVKDEPLELDEAEAWVSMaqhHNQTKPTKIELTLL...SVNPKPCLFFKLPP.PPLQpSTLTGPTTSTPVSTPNPSMPSPdpsaaAPTPPPSSAEQ..AQTPIAQSLDPADSETIlidKTEETWSITLSHRVNISPSLAnYHPALASGY...LLRRRDGTSDTEGLASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.76|      18|      66|      98|     119|       4
---------------------------------------------------------------------------
   98-  116 (26.53/20.22)	LTSLQI.GAITFKQfHAEFT
  175-  193 (25.23/ 9.38)	LRATQLhGAIPLGK.RALFT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03919 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MGRVNTSLQNSHGAHDGDALDIAGTSHDAVERPAGSAEPEERKDSMRNREHRVVLVPPAVSSPKENVQADLPIESGNIISPTPVTPHQPLSPSIIRKIL
2) NAESDQMEMHPSDIPRVGIPEWRNEERRALPMEDSSRDRLKSGMQSSSDSSAESSEDDSEPETTPLDYSNRGLR
3) PGVSSLSHAHPQNTSRRSDVNISGAGCQSTSNSLPPVDITTTALEIGS
4) QPSTLTGPTTSTPVSTPNPSMPSPDPSAAAPTPPPSSAEQAQTPIAQSLDPADS
5) WVTEMTTRTSPEDQMAVETHVAEGMQPEATGTTEKTS
579
730
484
1325
401
677
803
531
1378
437










Molecular Recognition Features






MoRF SequenceStartStop




1) KYELDGRFWF
718
727