<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03881

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEVLHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLEISLPKEISEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKAGPIKLEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNVLRQGRWKDAIKSELISDIGTGQGGSNAVMQLGQDGELDSSGSRIPGLKINYWLEEKNNASAESDSSPYIKIEAGQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELMKNVQMSQSSTEVILKREVHGEGFQKRVHRRDSNDCCTNEMLQVRAYGQSYIDLGINIRNGRFLLQSLGNILPPSAVLDSEEALNKGSTTATDVFVSLRTRSILHLFAATGSSLGLKVYSQSQVTLKIAKSILCGSEFMVMGFPQCANAYYLLMQLDKSFKPVFCLLEIQSNEGDNNNADATTDAKEAIRFIRIDINKLKIDEDVQIGNFFDKDKLLALQNVEDRPQRQSGADEPLPARPSFFSIVDEVFRCDRGSPITESQRLPPNSLPSSHSSYQVGLHGFSGGAGSPDQDYGSLQSNINAAKVTSGTGLNNYLLSNSKNAQSTSAFSGSVPAGLGNVSSSRSEGAYKKRSLSEFLQNIPSSKQSIIGDGPGKRRKLSEFMLDGLPLKANSPNMQPRTSLTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSRNIPHVEEVGMPTSSSNLWLRLPFAHDASWKHICLHLGKAGSMSWDVRINDPHYGALWKLHGGSTTTEWGSGVRVANTSEVDSHISFDDDGVLLTYNTVEADSIQRLVSDLQRLSHARAFSCGMRRLIGVKLDGKLAEHQTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEIASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAGYSALPKQNNILTTAGSANSLSSSTVHNMSVPQGAAVAHSNSQLQTSSMLSVAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLNASANTVSGNQQLASAPNRFGGAPGVARPTSTVANQVASSLSRAGNAMMPSGFASGIAGAPAHLSPGNVPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSSKSNIHHDRANNSVDFALTFVLDQALVPHMSISGGAAWLPYCVSVRVRYTFGEDSHIAFLAMDGSHSGRACWLQHEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLLQLRDSPVSTGSAAS
Length1684
PositionTail
OrganismOryza rufipogon (Brownbeard rice) (Asian wild rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.213
Instability index49.88
Isoelectric point7.99
Molecular weight185011.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03881
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.28|      40|     360|    1196|    1235|       1
---------------------------------------------------------------------------
  652-  684 (30.18/10.98)	...FSiVDevFR.CDRGSPITESQRLPPNSLPSSHSS........
 1196- 1235 (80.53/40.89)	RNKFS.VD..MR.CFAGDQVWLQPATPPKGGPSVGGSLP.CPQFR
 1557- 1594 (51.57/23.68)	RANNS.VD..FAlTFVLDQA.LVPHMSISGGAAW...LPyCVSVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.78|      21|     360|     113|     134|       2
---------------------------------------------------------------------------
  113-  134 (33.78/21.89)	LQQARAPIFDvPSAI....EVLHTGS
  473-  497 (31.00/15.61)	LLQSLGNILP.PSAVldseEALNKGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.73|      46|     360|     698|     746|       3
---------------------------------------------------------------------------
  701-  746 (79.77/51.71)	QDYGSLQSNINAAKVTSGTGLNNYL..LSNSKNAQSTSAF.S..G..SVPAGL
 1244- 1288 (67.26/35.04)	QGLNALEPNLLNARHT.GPPLNASA..NTVSGNQQLASAP.NrfG..GAP.G.
 1290- 1327 (37.70/17.27)	............ARPTS.TVANQVAssLSRAGNAMMPSGFaS..GiaGAPAHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.02|      31|     360|     176|     215|       4
---------------------------------------------------------------------------
  180-  213 (51.25/50.93)	ISEVSVTDGIAN..VQV..DGEfkvLITLGYR..G.HFSLW
  294-  331 (39.77/15.63)	ISDIGTGQGGSNavMQLgqDGE...LDSSGSRipGlKINYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.51|      20|      24|     748|     771|       7
---------------------------------------------------------------------------
  752-  771 (36.56/33.16)	SR....SEGAYKKRSLSEF.LQNIP
  773-  797 (27.95/12.68)	SKqsiiGDGPGKRRKLSEFmLDGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.83|      10|     664|     930|     942|       8
---------------------------------------------------------------------------
  933-  942 (19.20/18.21)	TSEVDSHISF
 1598- 1607 (19.64/ 7.41)	TFGEDSHIAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.80|      37|      59|    1451|    1487|       9
---------------------------------------------------------------------------
 1451- 1487 (65.11/39.29)	PQNNGQEELTVPEISEICDYFSRRVASEPYDASRVAS
 1513- 1549 (64.69/38.99)	PQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.13|      19|      24|    1330|    1353|      10
---------------------------------------------------------------------------
 1330- 1348 (35.17/30.89)	GNVP.AHMKGELNTAFIGLG
 1356- 1375 (29.96/12.29)	GWVPlAALKKVLRGILKYLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03881 with Med14 domain of Kingdom Viridiplantae
Unable to open file!