<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03774

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAGELGQQRVELGAVVQRAAEESYLSLRELVEKSQAEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLDASVRYKVLVTPRPKEVSNFSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLELLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGNAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKVGGSAESDSSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLCCIDVEQLILRAIACNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDLVKKTEQKDFADCCGNEVLQVRAYGQAYSPENILPPSALLDCEEALNKGSITATDAFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASDKTNTNACTKEALRFNKIDIGQIHISKSEPNANMFDVKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGAGTRANASIQEGVSSAYSGSKFSPGVSLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTEHVFADGSKSLQLVPSSKINGSINLITMGSDGASRKRSISDLFLNLPSLQGLKPSSPRKRRKISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGIKLNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQTNNIPTQGPLTNGSSSTTMHHAPAPANAAATHLGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQGGAHLNSSAGTLQSAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNNAQEELTPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1726
PositionTail
OrganismOryza punctata (Red rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index49.04
Isoelectric point7.72
Molecular weight188797.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03774
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     345.85|     110|     132|    1140|    1271|       1
---------------------------------------------------------------------------
 1140- 1266 (170.25/137.47)	GGAI....RPARMPvTVSSGYNSMPKQTNNiPTQGPLTNGSSSTTMHHAPAPANAAATH........LGSHNlHTAAMLSaagRGGPGLVPSSLLPFDVsvvlrGPYWIRIIYRKKFSVDMRcfaGDqvwLQPATPPKG
 1272- 1393 (175.60/108.90)	GSLPcpqfRPFIME.HVAQGLNALEPSFMN.ATQGGAHLNSSAGTLQSAPNANRVNATQgigmsrpaSGVAN.HVAANLS...RAGNAMLASSGLASGI.....GGASVRLTSGANLPVHVK...GE...LNTAFIGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.49|      25|     105|     206|     230|       2
---------------------------------------------------------------------------
  206-  230 (45.07/29.26)	LLTLGYRGHLDL..WRI..LHLELLVGDK
  312-  340 (36.42/22.17)	LMQLGQDGEYDLsgSRIpgLKINYWLDEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.17|     107|     135|     434|     544|       4
---------------------------------------------------------------------------
  371-  432 (62.19/37.11)	.......................................ILDP..LTDKE.ANL.SL.DLCCIDV......EQL...ILRAI.ACNRHTRLL..DIQRQLSKNVQIsqsPKDVILKRD.......
  434-  544 (173.76/132.90)	EIAKDLVKKTEqkdfADCCGNEVLQVRA..YGQAYSPENILPPSALLDCE.EAL.NKGSITATDAFAS.LRTRS...ILHLF.AATGSFFGL..KVYEKSQGTLKI...PKDILHGSDLMVMGFP
  568-  682 (143.22/99.66)	ETQSDASDKTN....TNACTKEALRFNKidIGQIHISKS.EPNANMFDVKlHALqNIGN..CDDVMENrLPIQSgiePLPLLpACSPSFSSVvdEVFEYEHGALAV...PNHSLPQTTLQSTSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      66.40|      23|     136|     930|     961|       5
---------------------------------------------------------------------------
  906-  921 (24.47/ 9.09)	.......LR..SPSSN........LW...LRL..PFAR
  923-  950 (35.95/27.97)	DSWKhicLRlgKAGSM........SW..DVRINDPHFR
  951-  972 ( 5.98/ 8.43)	ELWE............lstgstttSWgvGVRVAN....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.55|      12|      31|     744|     755|      11
---------------------------------------------------------------------------
  744-  755 (21.55/12.16)	SSSIKL.PSSNSN
  773-  785 (17.00/ 7.92)	SKSLQLvPSSKIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.54|      14|      18|    1402|    1416|      13
---------------------------------------------------------------------------
 1402- 1416 (19.35/19.89)	WVpLAALKKVLRGIL
 1423- 1436 (25.19/18.59)	WL.FAQLPELLKEIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03774 with Med14 domain of Kingdom Viridiplantae
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