<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03770

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEVLHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLEISLPKEISEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKAGPIKLEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNVLRQGRWKDAIKSELISDIHSGAGQGGSNAVMQLGQDGELDSSGSRIPGLKINYWLEEKTNASAESDSSPFIKIEAGQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELMKNVQMSQSPTEVILKQEVHGEGFQKKVNRRDSSDCCTDEMLKVRAYGQSYIDLGINIRNGRFLLQSLGNILPPSAVLDSEEALNKGSTTATDVFVSLRTRSILHLFAATGSSLGLKVYSQSQVTLKIPKSILCGSEFMVMGFPQCANAYYLLMQLDNSFKPVFCLLEIQNNEGDNNNADATTDAKEAIRFIRIDINKLKIDEDVQIANFFDKDKLLALQNVEDRPQRQSGTDEPLPARPSFSSVVDEVFGYDRGSPITESQRLPSNSLPSSHSSYQVGLHGVSGGAGSPDQDYGSLQSNINTAKVTSGTGLNNYLLSNSKHAQSTSAFSGSVSAGLGNISSSRSEGAYKKCSLSEFLQNIPLSKQSIIGDGPSKRRKVSEFMLDGLPLKANSPSMQPGTPLTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNIPHVEEVGMPTPSSNLWLCLPFAHDASWKHICLNLGKAGSMSWDVRINDPHYGALWKLHGGSTTTEWGSGVRVANTSEVDSHISFDDDGVLLTYNTVEADSIQRLVSDLQRLSHARAFSCGMRRLIGVKLDGKLAEHQTTAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSSCTLRVSPDQLWPHTKFLEDFVNGDEIASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAGYSALPKQNNILTTVGSANSLSSTVHNMSVPQGAAVAHSNSHLQTSSMLSAAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLNASVNTVSGSQQLAPSSNRFGGAPGIARPTSTVANQVASSLSRAGNAMIPSGFASGIAGAPAHLSPGNVPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLNVKRFHHQQQQQQQAPQNNGQEELTVPEIILREFIKLIAWKKSLPQAHADNATTHRARIELCLEKHPRLVSDDYTASSSSSKSNIHHDRANNSVDFALTFVLDQALVPHMSISGGAAWLPYCVSVRVKYTFGEDNHIAFLAMDGSHSGRACWLQHEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLLQLRDSPVSTGSAAS
Length1652
PositionTail
OrganismOryza punctata (Red rice)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.200
Instability index49.04
Isoelectric point7.17
Molecular weight181084.26
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03770
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1749.89|     545|     579|     484|    1062|       1
---------------------------------------------------------------------------
  108-  395 (139.56/62.15)	..............................................................................................................................................................................................................................................................................................................................................FMHE..G.LqqaraPI.FDVPSaievLHTGSYRRVPKCVEEIGTQNT..........LFQdeqkpTLKKL.STLVR.....AKLLEISLP..kEISEVSVTDGIANVQ..VDGE......FkvlitlgyrGHFSLWRilHMELLVGeKA.G....PIKLEETRRYAL..............GDDIERRMAVADNpfmilytilhelcISLV..MDTV......IRQTNVLRqgrwKDAIKsELISDI....HSGA.GQGGSNAVMQ.LGQDGELDssgsripglkinywlEEKTNA........SAESD......SSPFiKIEAGQDMQIKCQHSS.....FVLDPFTDKEadlsidlSCidveALILKA
  484- 1062 (853.54/540.95)	PPSAVLdsEEALNkGSTTAT..DVfVSLRTRSILHLFAA.TGSSLGLKV...YS....QSQVTLKIPKSILCGSEFMVMGFPQCANAYYllmqlDNSFKPVFCLLEI..QNNEGDNNNADATTDAKEAIR...FIRIDI.NKLKIDedvqiANFFDKDKLLaLQNVEDrPQRQSGTDEPLPArPSFSSVVDEvfGYDRGSPITEsqrlPsNSLPSSHSS..YQVGLHGVSGGAG.SPDQD.YGSLQsniNTAKVTSgTGLNNYL..LSNSKHAQSTSAFSGSVSAGLGNISSSrSEGAYKKCSLSEFLqnIPLSKQSIIGDG..P.SKRRKVSEFMLD..G.L.....PLKANSPS....MQPGTPLTYGKLLEEVNNCITANI...YSSVLLH.....VIKHC.SICIKYAQLTAQMDSLNIP...HVEEVGMPTPSSNLW..LCLP......F.........AHDASWK..HICLNLG.KA.GSMSWDVRINDPHYGALWKlHGGSTTTEWgsGVRVANTSEVDSH.............ISFD..DDGV......LLTYNTVE....ADSIQ.RLVSDLQRLSHARA.FSCGMRRLIG.VKLDGKLA...............EHQTTAETKLHSRRKASRDRLSEQMRKTF.RIEAVGLMSLWFSYGAVPMVYFVVEWETGKS.......SC....TLRVSP
 1067- 1644 (756.79/409.13)	PHTKFL..EDFVN.GDEIASflDC.IRLTAGPLLALGGAiRPAKMPVTVpagYSalpkQNNILTTVGSANSLSSTVHNMSVPQGAAVAH.....SNSHLQTSSMLSAagRTAPGLVPSSLLPFDVSVVLRgpyWIRIIYrNKFSVD.....MRCFAGDQVW.LQPATP.PKGGPSVGGSLPC.PQFRPFIME..HVAQGLNALE....P.NLLNARHTGppLNASVNTVSGSQQlAPSSNrFGGAP...GIARPTS.TVANQVAssLSRAGNAMIPSGFASGIAGAPAHLSPG.NVPAHMKGELNTAF..IGLGDDGGYGGGwvPlAALKKVLRGILKylGvL.....WLFAQLPD....L...LKEILGSVLKD.NEGALLNLdheQPALRFF.....VGGYVfAVSVHRVQLLLQV..LNVKrfhHQQQQQQQAPQNNGQeeLTVPeiilreF.........IKLIAWK..K.SLPQA.HAdNATTHRARIE....LCLEK.HPRLVSDDY.....TASSSSSKSN.............IHHDraNNSVdfaltfVLDQALVP....HMSIS.GGAAWLPYCVSVRVkYTFGEDNHIAfLAMDGS..................HSGRACWLQHEDWERCKQRVSRAVETMN.GSAAVGDM....SQGRLRMVAEMVQKQLQLS.......LL....QLRDSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.43|      18|      25|     418|     435|       3
---------------------------------------------------------------------------
  418-  435 (30.86/18.91)	SQSPTEVILKQEVHGEGF
  445-  462 (33.56/21.19)	SDCCTDEMLKVRAYGQSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03770 with Med14 domain of Kingdom Viridiplantae
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