<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03608

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAEESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSLDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLEVLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSSFILDPWTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPLSVGFQGVGTRANASIEGASSAYSGSKFSPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTEHVIADGSKSLQLVPASKINGSINLITMGSDGASRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVKLNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHLGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQPAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1738
PositionTail
OrganismOryza nivara (Indian wild rice) (Oryza sativa f. spontanea)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.196
Instability index50.27
Isoelectric point7.99
Molecular weight190232.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03608
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     370.39|     119|     135|    1091|    1225|       1
---------------------------------------------------------------------------
 1091- 1225 (194.51/152.88)	GTMP..MVHFVVEwesakggctmHVSPDQLW....PHTKFLEDF.VNGGEVASFLDCIRLTAGPLLalGGAI.....RPARMPvTVSSGYNSM.PKQMNniPTQGPLANGSSSTTMHHAPSPANVAATH........LGSHNlHTAAMLS............AAGRGG
 1227- 1378 (175.88/103.83)	GLVPssLLPFDVS..........VVLRGPYWiriiYRKKFSVDMrCFAGDQVWLQPATPPKGGPLV..GGSLpcpqfRPFIME.HVAQGLNALePSFMN..ATQAGAHLNSSAGTLQPAPNANRVNATQgigmsrpaSGVAN.HVAANLSragnamlassglASGIGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.00|      49|     105|     206|     254|       2
---------------------------------------------------------------------------
  206-  254 (81.09/46.61)	LLTLGYRGHLDL..WRI..LHLEVLVGDKGGPIKLEER.RRFALGDDIERR..MAV
  257-  297 (45.19/22.80)	......NPFMVL..YAI..LHELCISLAMDTIIRQTNVlRQGRWKDAIRSE.....
  312-  363 (59.72/32.44)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDS.SPFI...KIEARqdMQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.53|      21|      22|     812|     833|       3
---------------------------------------------------------------------------
  514-  532 (27.81/12.54)	RTRSILHLFAATGSFFGLK..
  812-  832 (36.26/20.30)	RKRSISDLFLNLPSLQGLKPS
  836-  853 (30.46/16.38)	KRRRISE...SMESWSPLQAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.42|      27|     136|     533|     559|       4
---------------------------------------------------------------------------
  533-  559 (48.01/28.14)	VYEKSQGTLKIPKDILHGSDLMVMGFP
  671-  697 (48.41/28.43)	VFEYEHGALAVPNHSLPQTTLQSTSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.24|      12|      32|     756|     767|       6
---------------------------------------------------------------------------
  756-  767 (20.97/13.56)	SSSIKL.PSSNSN
  785-  797 (16.27/ 8.57)	SKSLQLvPASKIN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03608 with Med14 domain of Kingdom Viridiplantae
Unable to open file!