<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03570

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAAESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLELLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSLFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFAPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTENVIADGSKSLQLVPASKINGSINLITMGSDGPSRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVILNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHVGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQSAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismOryza meridionalis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index50.45
Isoelectric point7.99
Molecular weight190217.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03570
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     354.67|     116|     133|    1154|    1286|       1
---------------------------------------------------------------------------
 1148- 1280 (181.40/131.67)	GPLLALG...GAIRPARMPvTVSSGYNSM.PKQMNniPTQGPLANGSSSTTMHHAPSPANVAATH.VG.SHNL.....HTAAMLSaagRGGPGLVPSSLLPFDVsvvlrGPYWIRIIYRKKFSVDMRcfaGDqvwLQPATPPKG
 1281- 1407 (173.26/91.01)	GPLVGGSlpcPQFRPFIME.HVAQGLNALePSFMN..ATQAGAHLNSSAGTLQSAPNANRVNATQgIGmSRPAsgvanHVAANLS...RAGNAMLASSGLASGI.....GGASVRLTSGANLPVHVK...GE...LNTAFIGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.45|      18|      19|     786|     804|       2
---------------------------------------------------------------------------
  758-  782 (17.02/ 6.51)	.SSSIKL.PSSNSNHE...LsslsspteNV
  786-  804 (26.49/19.77)	GSKSLQLvPASKINGS...I........NL
  808-  825 (20.93/ 9.88)	GSDG....PSRKRSISdlfL........NL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.60|      39|     132|     521|     559|       3
---------------------------------------------------------------------------
  521-  559 (68.81/53.60)	LFAATGSFFGL..KVYEKSQGTLKIPKDILHGSDLMVMGFP
  657-  697 (65.79/50.85)	LPACSPSFSSVvdEVFEYEHGALAVPNHSLPQTTLQSTSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.68|      78|     107|     206|     286|       4
---------------------------------------------------------------------------
  206-  286 (128.94/85.85)	LLTLGYRGHLDL..WRI..LHLELLVGDKGGPIKLEERRRFAlgdDIERR..MAVS.ENPFMVLYAIL.HELCISLAMDTIIRQTNVLR
  312-  397 (110.74/66.38)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDSSPFI...KIEARqdMQIKcQHSLFILDPLTdKEANLSLDLCCIDVEQLILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      32|     132|     944|     975|       5
---------------------------------------------------------------------------
  944-  975 (59.56/43.37)	LRLGKAGSMS.W..DVRINDPHFRELWELSTGSTT
 1078- 1112 (52.12/36.89)	FRIEAVGLMSlWfsYGTMPMVHFVVEWESAKGGCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.54|      14|      18|    1416|    1430|      10
---------------------------------------------------------------------------
 1416- 1430 (19.35/18.32)	WVpLAALKKVLRGIL
 1437- 1450 (25.19/17.12)	WL.FAQLPELLKEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.98|      23|     128|     848|     879|      14
---------------------------------------------------------------------------
  848-  870 (43.29/38.06)	SWS.PLQ.AYSSDSQSRTS.......LTYGNI
  977- 1008 (27.69/ 7.53)	SWGvGVRvANTSEMDSHISfdaegviLTYSNV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03570 with Med14 domain of Kingdom Viridiplantae
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