<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03569

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLELLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSLFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFAPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTENVIADGSKSLQLVPASKINGSINLITMGSDGPSRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVILNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHVGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQSAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1627
PositionTail
OrganismOryza meridionalis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.168
Instability index51.46
Isoelectric point7.90
Molecular weight177553.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03569
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     354.67|     116|     133|    1041|    1173|       1
---------------------------------------------------------------------------
 1035- 1167 (181.40/169.01)	GPLLALG...GAIRPARMPvTVSSGYNSM.PKQMNniPTQGPLANGSSSTTMHHAPSPANVAATH.VG.SHNL.....HTAAMLSaagRGGPGLVPSSLLPFDVsvvlrGPYWIRIIYRKKFSVDMRcfaGDqvwLQPATPPKG
 1168- 1294 (173.26/116.86)	GPLVGGSlpcPQFRPFIME.HVAQGLNALePSFMN..ATQAGAHLNSSAGTLQSAPNANRVNATQgIGmSRPAsgvanHVAANLS...RAGNAMLASSGLASGI.....GGASVRLTSGANLPVHVK...GE...LNTAFIGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      64.45|      18|      19|     673|     691|       2
---------------------------------------------------------------------------
  645-  669 (17.02/ 6.08)	.SSSIKL.PSSNSNHE...LsslsspteNV
  673-  691 (26.49/18.42)	GSKSLQLvPASKINGS...I........NL
  695-  712 (20.93/ 9.22)	GSDG....PSRKRSISdlfL........NL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.60|      39|     132|     408|     446|       3
---------------------------------------------------------------------------
  408-  446 (68.81/45.01)	LFAATGSFFGL..KVYEKSQGTLKIPKDILHGSDLMVMGFP
  544-  584 (65.79/42.70)	LPACSPSFSSVvdEVFEYEHGALAVPNHSLPQTTLQSTSHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     239.68|      78|     107|      93|     173|       4
---------------------------------------------------------------------------
   93-  173 (128.94/96.08)	LLTLGYRGHLDL..WRI..LHLELLVGDKGGPIKLEERRRFAlgdDIERR..MAVS.ENPFMVLYAIL.HELCISLAMDTIIRQTNVLR
  199-  284 (110.74/74.31)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDSSPFI...KIEARqdMQIKcQHSLFILDPLTdKEANLSLDLCCIDVEQLILR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      32|     132|     831|     862|       5
---------------------------------------------------------------------------
  831-  862 (59.56/39.98)	LRLGKAGSMS.W..DVRINDPHFRELWELSTGSTT
  965-  999 (52.12/33.98)	FRIEAVGLMSlWfsYGTMPMVHFVVEWESAKGGCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.54|      14|      18|    1303|    1317|       7
---------------------------------------------------------------------------
 1303- 1317 (19.35/19.65)	WVpLAALKKVLRGIL
 1324- 1337 (25.19/18.37)	WL.FAQLPELLKEIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.98|      23|     131|     735|     766|       8
---------------------------------------------------------------------------
  735-  757 (43.29/39.71)	SWS.PLQ.AYSSDSQSRTS.......LTYGNI
  864-  895 (27.69/ 7.89)	SWGvGVRvANTSEMDSHISfdaegviLTYSNV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03569 with Med14 domain of Kingdom Viridiplantae
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