<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03568

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAAESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLQQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLELLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSLFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFAPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTENVIADGSKSLQLVPASKINGSINLITMGSDGPSRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGKGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVILNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHVGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQSAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLTSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1688
PositionTail
OrganismOryza meridionalis
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.06
Grand average of hydropathy-0.184
Instability index50.65
Isoelectric point8.44
Molecular weight184354.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03568
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     296.13|      95|     820|      18|     149|       1
---------------------------------------------------------------------------
   18-  149 (137.61/167.23)	RRAAAESYLSLRELVEKSQDEGEGKGGAYGarqrsdsekkidllkfiartrqrmlrlHVLAKWCQQVPLVNYCQQLGSTLsSHetCftqtadSLYFMHEGLqQARAPMFDIPSALEVML...TGN.YQRLPLCIED
  839-  937 (158.52/108.69)	RRRISESMESWSPLQAYSSDSQSRTSLTYG...........................NILAERNNCVPATTYASVLLHVI.RH..C......SLSIKHAQI.TAQMDSLAIPYVEEVGLrspSSNlWLRLPFARDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.89|      86|     580|     482|     735|       2
---------------------------------------------------------------------------
  646-  735 (135.96/292.37)	PIQSGiePL..PLLPaCsPSFSSVVDEVFEYEHGAL..AVPNHSLPQTTLQST.....SHPGSLSV.GFQGVG.TRANASIE...GASSAYSGSKFAPGVGLNS
 1229- 1328 (119.94/24.40)	PPKGG..PLvgGSLP.C.PQFRPFIMEHVAQGLNALepSFMNATQAGAHLNSSagtlqSAPNANRVnATQGIGmSRPASGVAnhvAANLSRAGNAMLASSGLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.64|      21|     821|     234|     254|       3
---------------------------------------------------------------------------
  234-  254 (36.39/22.50)	IKLEERRRFALGDDIER.RMAV
 1095- 1116 (33.25/19.89)	IRLTAGPLLALGGAIRPaRMPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.07|      68|     821|     511|     614|       5
---------------------------------------------------------------------------
  434-  509 (102.22/116.50)	EIAKDPVKKTEQ..KDFADCcgnevlqVRAYgQAYIGLGINIRSGRFLLQSPENILPPSALLDC.EEALNKGSITATDV
  542-  612 (108.85/81.44)	KIPKDILHGSDLmvMGFPQC.......ANAY.YLLMQLDKDFRPVFHLLETQSDANDKTNTNACtKEALRFNKIDIGQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.25|      22|    1041|     305|     329|       6
---------------------------------------------------------------------------
  305-  329 (32.91/31.79)	GQTGSApLMQLGQDGEYdlSGSRIP
 1349- 1370 (43.34/27.95)	GELNTA.FIGLGDDGGY..GGGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.00|      31|     400|    1182|    1225|       7
---------------------------------------------------------------------------
 1189- 1225 (47.03/58.76)	PFDVSVVLRgpYWI....RIIYrkkFSVDmRCFAGDQVWLQ
 1592- 1626 (56.97/31.14)	PYCVSVRLK..YSFgesnHIAY...LAMD.GSHGGRACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.80|      26|      26|     738|     763|       8
---------------------------------------------------------------------------
  738-  763 (42.82/23.19)	P.SNLRH.VQSTNAFSSSTVTK.SSSIKL
  764-  792 (29.97/14.19)	PsSNSNHeLSSLSSPTENVIADgSKSLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03568 with Med14 domain of Kingdom Viridiplantae
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