<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03449

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEGELGQQTVELGAVVRRAAEESYLSLRELVEKSQDEGEGKGGAYGARQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMHEGLEQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQNKLSPDEEKRALQKLNASVRYKVLVTPRPKEVSNVSVADGIAVFRVDGEFKVLLTLGYRGHLDLWRILHLEVLVGDKGGPIKLEERRRFALGDDIERRMAVSENPFMVLYAILHELCISLAMDTIIRQTNVLRQGRWKDAIRSELVSDSTTGQTGSAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKAGGSAESDSSPFIKIEARQDMQIKCQHSSFILDPLTDKEANLSLDLCCIDVEQLILRAIASNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVEIAKDPVKKTEQKDFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSPENILPPSALLDCEEALNKGSITATDVFASLRTRSILHLFAATGSFFGLKVYEKSQGTLKIPKDILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDANDKTNTNACTKEALRFNKIDIGQIQISKSESNTNMFDAKLHALQNIGNCDDVMENRLPIQSGIEPLPLLPACSPSFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAYSGSKFSPGVGLNSYLPSNLRHVQSTNAFSSSTVTKSSSIKLPSSNSNHELSSLSSPTEHVIADGSKSLQLVPASKINGSINLITMGSDGASRKRSISDLFLNLPSLQGLKPSSPRKRRRISESMESWSPLQAYSSDSQSRTSLTYGNILAERNNCVPATTYASVLLHVIRHCSLSIKHAQITAQMDSLAIPYVEEVGLRSPSSNLWLRLPFARDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELSTGSTTTSWGVGVRVANTSEMDSHISFDAEGVILTYSNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVKLNDKLDDDQTSTDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMPMVHFVVEWESAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYNSMPKQMNNIPTQGPLANGSSSTTMHHAPSPANVAATHLGSHNLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPLVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNSSAGTLQPAPNANRVNATQGIGMSRPASGVANHVAANLSRAGNAMLASSGLASGIGGASVRLPSGANLPVHVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNSAQEELAPPEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIEICLENHSGSVSDDITESTLAKSNVKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLKYSFGESNHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismOryza glumipatula
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.198
Instability index50.57
Isoelectric point7.87
Molecular weight190284.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03449
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     186.00|      49|     105|     206|     254|       1
---------------------------------------------------------------------------
  206-  254 (81.09/50.09)	LLTLGYRGHLDL..WRI..LHLEVLVGDKGGPIKLEER.RRFALGDDIERR..MAV
  257-  297 (45.19/24.44)	......NPFMVL..YAI..LHELCISLAMDTIIRQTNVlRQGRWKDAIRSE.....
  312-  363 (59.72/34.82)	LMQLGQDGEYDLsgSRIpgLKINYWLDEKAGGSAESDS.SPFI...KIEARqdMQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     345.47|      82|     133|    1148|    1236|       2
---------------------------------------------------------------------------
  732-  787 (41.42/19.60)	..........................GLNSYlPSNLR..HVQSTNAFSSStvtkSSSI.KLPSSNS..NHE........LSSLSSpteHVIADGS.............
 1148- 1234 (138.45/110.68)	GPLLalGGA.....IRPARMPvTVSSGYNSM.PKQMNniPTQGPLANGSS....STTMHHAPSPANVAATH........LGSHNL...HTAAMLSAAGRGGPGLVPSS
 1281- 1372 (114.67/71.27)	GPLV..GGSlpcpqFRPFIME.HVAQGLNALePSFMN..ATQAGAHLNSS....AGTLQPAPNANRVNATQgigmsrpaSGVAN....HVAANLS...RAGNAMLASS
 1374- 1418 (50.93/25.99)	............................................LASGIG....GASV.RLPSGANLPVHV........KGELNT...AFIGLGDDGGYGG.GWVP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.53|      21|      22|     814|     835|       3
---------------------------------------------------------------------------
  514-  532 (27.81/12.32)	RTRSILHLFAATGSFFGLK..
  814-  834 (36.26/19.89)	RKRSISDLFLNLPSLQGLKPS
  838-  855 (30.46/16.07)	KRRRISE...SMESWSPLQAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.67|      32|     136|     944|     975|       4
---------------------------------------------------------------------------
  944-  975 (59.56/41.39)	LRLGKAGSMS.W..DVRINDPHFRELWELSTGSTT
 1078- 1112 (52.12/35.17)	FRIEAVGLMSlWfsYGTMPMVHFVVEWESAKGGCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.34|      72|     567|      85|     158|       6
---------------------------------------------------------------------------
   85-  158 (124.21/84.10)	PLVNYCQQlgSTLSSHETCFTQTADSLYFMHEGLEQARAPMFDIPSALEVMLTGNYQRLPLCIEDIGSQ...NKLSP
  655-  729 (119.13/74.64)	PLLPACSP..SFSSVVDEVFEYEHGALAVPNHSLPQTTLQSTSHPGSLSVGFQGVGTRANASIEGASSAysgSKFSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.35|      12|      18|    1419|    1430|      11
---------------------------------------------------------------------------
 1419- 1430 (18.43/10.17)	LAALKKVLRGIL
 1439- 1450 (19.91/11.58)	FAQLPELLKEIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03449 with Med14 domain of Kingdom Viridiplantae
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