<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03442

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEVLHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLEISLPKEISEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKAGPIKLEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNVLRQGRWKDAIKSELISDIGTGQGGSNAVMQLGQDGELDSSGSRIPGLKINYWLEGKNNASAESDSSPYIKIEAEQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELMKNVQMSQSPTEVILKREVHGEGFQKRVHRRDSNDCCTNEMLQVRAYGQSYIDLGINISNTLVKVPNILHYESIVILVYSQSQVTLKIPKSILCGSEFMVMGFPQCANAYYLLMQLDKSFKPVFCLLEIQSNEGDNNNADATTDAKEAIRFIRIDINKLKIDEDVQIGNFFDKDKLLALQNVEDRPQRQSGADEPLPARPSFFSVVDEVFRCDRGSPITESQRLPPNSLPSSHSSYQVGLHGFSGGAGSPDQDYGSLQSNINAAKVTSGTGLNNYLLSNSKNAQSTSAFSGSVPAGLGNVSSSRSEGAYKKRSLSEFLQNIPSSKQSIIGDGPGKRRKLSEFMLDGLPLKANSPNMQPGTSLTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNIPHVEEVGMPTSSSNLWLRLPFAHDASWKHICLHLGKAGSMSWDVRINDPHYGALWKLHGGSTTTEWGSGVRVANTSEVDSHISFDDDGVLLTYNTVEADSIQRLVSDLQRLSHARAFSCGMRRLIGVTLDGKLAEHQTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEIASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAGYSALPKQNNILTTAGSANSLSSSTVHNMSVPQGAAVAHSNSQLQTSSMLSVAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLNASANTVSGNQQLASAPNRFGGAPGVARPTSTVANQVASSLSRAGNAMMPSGFASGIAGAPAHLSPGNVPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSSKSNIHHDRANNSVDFALTFVLDQALVPHMSISGGAAWLPYCVSVRVRYTFGEDSHIAFLAMDGSHSGRACWLQNEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLLQLRDSPVSTGSAAS
Length1644
PositionTail
OrganismOryza glumipatula
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.208
Instability index49.39
Isoelectric point7.28
Molecular weight180751.92
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03442
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.18|      22|      23|     706|     728|       1
---------------------------------------------------------------------------
  681-  699 (30.22/12.78)	LNNYLLSN....SKNA...QSTSAFS
  706-  727 (38.12/19.59)	LGNVSSSR....SEGAYKKRSLSEFL
  729-  752 (25.84/12.48)	..NIPSSKqsiiGDGPGKRRKLSEFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.41|      20|      24|    1235|    1257|       2
---------------------------------------------------------------------------
 1235- 1257 (32.16/25.52)	QLASAPNRFGGA..P.GVArptSTVA
 1259- 1281 (27.25/13.09)	QVASSLSRAGNAmmPsGFA...SGIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.66|      20|      25|     841|     864|       3
---------------------------------------------------------------------------
  841-  864 (31.26/32.65)	H.DASWKhicLHlGKAGSMSW..DVRI
  868-  890 (31.40/17.77)	HyGALWK...LH.GGSTTTEWgsGVRV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     293.44|     103|     115|     180|     294|       4
---------------------------------------------------------------------------
  180-  292 (150.70/121.48)	ISEVSVTDGIAN..VQV..DGEfkvLITLGYR..G.HFSLWRILHMELLVGEKAGP.IKLEETRRYALgdDIERRMAVADnPFMilyTILHELCISL....VMDTVIRQTNVLRQGRWKDaIKSE
  294-  408 (142.74/92.57)	ISDIGTGQGGSNavMQLgqDGE...LDSSGSRipGlKINYWLEGKNNASAESDSSPyIKIEAEQDMQI..KCQHSSFVLD.PFT...DKEADLSIDLscidVEALILKAIACNRHTRLLE.IQRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.80|      37|      59|    1411|    1447|       5
---------------------------------------------------------------------------
 1411- 1447 (65.11/38.65)	PQNNGQEELTVPEISEICDYFSRRVASEPYDASRVAS
 1473- 1509 (64.69/38.36)	PQAHADNATTHRARIEICLEKHPRLVSDDYTASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.38|      10|      21|    1323|    1332|       6
---------------------------------------------------------------------------
 1323- 1332 (16.31/10.17)	LKKVLRGILK
 1347- 1356 (16.07/ 9.90)	LKEILGSVLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.08|      23|      24|     468|     490|       7
---------------------------------------------------------------------------
  448-  468 (26.82/18.91)	NEMLQVRA....YgQSYIDLGINIS
  469-  491 (36.65/29.20)	NTLVKVPN.ILHY.ESIVILVYSQS
  492-  514 (27.61/19.74)	QVTLKIPKsILCG.SEFMVMGFPQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.25|      12|      24|    1282|    1293|       8
---------------------------------------------------------------------------
 1282- 1293 (23.40/11.26)	GAPAHLSPGNVP
 1308- 1319 (25.85/13.24)	GDDGGYGGGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.17|      18|      30|     619|     636|       9
---------------------------------------------------------------------------
  619-  636 (34.93/22.64)	FRCDRGSPITESQRLPPN
  652-  669 (33.24/21.12)	FSGGAGSPDQDYGSLQSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.02|      15|      15|    1087|    1101|      12
---------------------------------------------------------------------------
 1087- 1101 (25.34/14.21)	GSANSLSSSTVHNMS
 1105- 1119 (24.68/13.65)	GAAVAHSNSQLQTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.63|      15|      15|     769|     783|      13
---------------------------------------------------------------------------
  769-  783 (26.13/16.26)	TSLTYGK.LLEEVNNC
  785-  800 (22.49/13.02)	TANIYSSvLLHVIKHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.74|      43|     407|    1121|    1174|      15
---------------------------------------------------------------------------
 1121- 1174 (60.18/61.86)	LSVAGrtapGlvpSSLLPFDVSVVLRGPYW..IRIIYrnkFSVDmRCFAGDQVWLQ
 1538- 1582 (78.56/46.19)	MSISG....G...AAWLPYCVSVRVRYTFGedSHIAF...LAMD.GSHSGRACWLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03442 with Med14 domain of Kingdom Viridiplantae
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