<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03337

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELRQQTVELGAVVRRAAEESYLSLRELVEKSRAEAEGKGPGGGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVNYCQQLGSTLSSHETCFTQTADSLYFMQEGLQQARAPMFDIPSALEIMVTGNYQRLPICIEDIGNQNKLSPDEEKRALQKLDTSVRYKVLVTPRPKEVSNVSVADGIAVLHVDGEFEVLLTLGYRGHLDLWRILHLELLVGDKSGAIKLEERRRFALGDDIERRMAVSDNPFMVLYAILHELCISLAMDTIIRQTNVLRLGRWKDAIRSELVSDSTTGQTGNAPLMQLGQDGEYDLSGSRIPGLKINYWLDEKVSGSAESDSSPFIKIEAGKDMQIKCQHSSFILDPLTDKEANLCLDLCCIDVEKLILRAIACNRHTRLLDIQRQLSKNVQISQSPKDVILKRDVETAKDPMKKTERKGFADCCGNEVLQVRAYGQAYIGLGINIRSGRFLLQSAENILPPSALLDCEEALNKGSITATDAFASLRTRSILHLFAATGSFFGLKVYQKSQGTVKIPNSILHGSDLMVMGFPQCANAYFLLMQLDKDFRPVFHLLETQSDASDKTSTNACTKEAMRFNKIDIGQIQISKSELNANMFDVKLHALQNIGNCDNIMENRLPIQSGIEPLPLLPASSPSFSSIVDEVFEYENGALAPNHCLPQTTSHPGSISVGYQGGSTRANTSIQVGASSAYSGSKNSSGISSYGYLPNNLRHVQSTNAFSSSAVAKSSSIKLPGASSDHELTSLSSPTEHVIADGSKSLQLVPSSKINGSGDVITLGSDGASRKRSLSDLFLNLPSLQGLKPSSPRKRRKISESMESWSSLQAYSSDLQSRTSLTYGNVLAERNNCVPATTYASVLLHVIRHCSLSIKHAQLTAQMDSLAIPYVEEVGLRSTSSNLWLRLPFARDHSWKHICLRLGKAGSMSWDVRINDPHFKELWELSTGSTTTSWGVRVRVANTSEMDSQISFDADGVILTYGNVEPDSVQKLVSDLRRLANARSFARGMRRLIGVKQDDKLDDDQPSMDIKSQPVNKGNSDAADRLSEQMRKTFRIEAVGLMSLWFSYGTMSMVHFVVEWENAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALSGAIRPARMPVTVSSGYNSMPKQANNIPTQGPLANGSSSTTMHHTPSANAAAAHLANHNLHNAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPPVGGSLPCPQFRPFIMEHVAQGLNALEPSFMNATQAGAHLNASAGTLQSAPNTNRVNATTGIAMSRPASGVANHVAANLSRAGNSMLATSGLASGIGGASVRLTPGANLPVQVKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKENEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNNAQEELVPAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSVSDDITESSLAKSNIKYDRAHSSLEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGESIHIAYLAMDGSHGGRACWLQYEDWERCKQKVARAVETVNGSVAVGESGQGRLRMVAEMVQKQLQICLQQLRDGPLSAGSTAS
Length1737
PositionTail
OrganismLeersia perrieri
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Leersia.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index46.89
Isoelectric point8.36
Molecular weight189771.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03337
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.27|      18|      35|    1144|    1161|       1
---------------------------------------------------------------------------
 1144- 1161 (32.23/19.74)	TAGPLLALSGAIRPARMP
 1180- 1197 (34.04/21.32)	TQGPLANGSSSTTMHHTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.19|      29|      29|    1366|    1394|       2
---------------------------------------------------------------------------
 1337- 1364 (38.46/19.44)	.ATT..GIA..MSRPASGVANHVAANLSRAGNS
 1366- 1394 (48.31/26.35)	LATS..GLA..SGIGGASVRLTPGANLPVQVKG
 1396- 1425 (35.41/17.29)	LNTAfiGLGddGGYGGGWV...PLAALKKVLRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     340.41|      97|     102|     651|     750|       3
---------------------------------------------------------------------------
  502-  555 (59.74/24.28)	NKGS...ITATDAFASlRTRSILHLFAATGSFFGLKVYQKSQGTVKIPNSILHGSDL..........................................................................................................................................................
  651-  692 (35.82/20.13)	..............................................................mvmgfpqcanayfllmqldkdfrpvfhlletqsdasdktstnactkeamrfnkidigqiqiskselnanmfdvklhalqnigncdnimenrlpiqSGIEpLPllPASS....PSFSSIVDEV.......FEYENGALAP.NHCLPQTTS
  693-  796 (140.08/67.46)	HPGS...ISVGYQGGS.TRANTSIQVGASSAYSGSKNSSGISSYGYLPNNLRHVQSTNAFSS.........................................................................................savaksSSIK.LP..GASSdhelTSLSSPTEHV.......IADGSKSL....QLVPSSKI
  797-  880 (104.77/48.76)	N.GSgdvITLGSDGAS.RKRSLSDLFLNLPSLQGLKPSSP.RKRRKISESMESWSSLQAYSS..........................................................................................................................dlqsrtsLTYGN.VLAErNNCVPATT.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.42|      34|     399|    1227|    1270|       4
---------------------------------------------------------------------------
 1233- 1270 (57.65/59.64)	LPFDVSVVLRGPY..WIRIIYrkkFSVDmRCFAGDQVWLQ
 1640- 1675 (61.77/36.43)	LPYCVSVRLRYSFgeSIHIAY...LAMD.GSHGGRACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.13|      60|     105|     170|     232|       7
---------------------------------------------------------------------------
  170-  232 (91.07/74.08)	LDTSVRY.KVLVTPRPKE.VSNVSVADgiAVLHVDGEfEVLLTLGYRGHLDL..WRI..LHLELLVGDK
  246-  276 (48.51/29.19)	LGDDIER.RMAVSDNPFM.V...............................L..YAI..LH.ELCISLA
  277-  342 (82.54/55.54)	MDTIIRQtNVLRLGRWKDaIRSELVSD..STTGQTGN.APLMQLGQDGEYDLsgSRIpgLKINYWLDEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.00|      30|     517|     380|     441|       8
---------------------------------------------------------------------------
  380-  409 (54.23/60.40)	KEANLC..LDLCCID.VEKLILRAIACNRHTRL
  897-  929 (42.77/ 8.64)	KHAQLTaqMDSLAIPyVEEVGLRSTSSNLWLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      58.55|      14|      19|     977|     990|      11
---------------------------------------------------------------------------
  953-  969 (15.55/ 6.54)	DVRINDPHFKELwelST
  977-  990 (22.25/12.72)	GVRVRVANTSEM...DS
  998- 1010 (20.75/11.33)	GVILTYGNV.EP...DS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03337 with Med14 domain of Kingdom Viridiplantae
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