<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03332

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEILHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLETSLPKEISEVSVTDGIANVKVDGEFKVLITLGYRGHFSLWRILHMELLVGEKTGPIKFEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNALRQGRWKDAIKSELISDIHSGAGQGGNNALMQLGQDGELDSSGSRIPGLKISYWLEEKSALAESDSSPFIKIEAGQDMKIKCQHSSFVLDPFTDKEAGLLIDPSRIDVEALILKAIACNRHTRLLEIQRELIKNVQMSQSPTEVILKREVHGEGFQKKVRIGGSDDCCTNEMLQVRAYGQSYIQLGINIRNGRFLLQSPGNILPPSAVSDSEEALNKGSATATDVFVSLRTRSILHLFAATASSLGLKVYSQSQVTLKIPKSILYGSDFMVMGFPQCANAYYLLMQLDNSFKPAFCLLEIQSNEGDKNNADATTDAKDTIRFIRIDINKLKIDEDVQIANFFDKDKLLALQNAEDRPPRKSGTDEPLPSRPSFSSVVDEVFVCDRGSPTTESQGFPFSSHSSYQVGLHGVRGGAGSPDQDYGSLQSNINSANGTSGVSMNNYLQSNSKHVQSTIAFSGSVPAGSGNISSSHSDGPSRKRSLSEFLPNIPSLKQYKIGDGPSKRRKVSEFMLDGLPLRASPNMQPGKILTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNISYIEEVGVQTASSNLWLRLPFAHDASWKHICLRLGKAGSMSWDVRINDPHYGALWKLYGGSTTTGWGSGVRVANTSEVDSHISFDGDGILLTYDTVEADSIQRLVLDLQRLSNARAFSCGMRRLIGVKLDDKIVKTLTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEVASFLDCIRLTAGPLLALCGAIRPAKMPVTVPSSYTALPKQNNILTTVGPANNSSSSTVPNMSVPQGAAVAHSNSHLQTSSMLSAAGRTTPGPPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDLRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPNLLNARHPGPQLNASFNTASGSQQSAPTTPNRFGGAPGVARPTSSVGNQVATSTSRAGNAMMASGFASGIPGAPAHLSPGNLGLGDDGSYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRIQLLLQVLNVKRFHHQQQQQQQTPQSNGQEELTPSDISEICDYFSRRVASEPYDASRVASFITLLTLPTSVLREFIKLIAWKKSFTQAHGDNGTTQRARIELCLEKHPRLVSDDYTASSSSSKSNIHHDRANSSVEFALTFVLDQGLVPHMSISGGAAWLPYCVSVRLRYTFGDNSHIVFLAMDGSHSGRACWLQNEDWERCKQKVARAVETMNGSAAIGDMSQGRLRMVAEMVQKQLQLSLLQLRDGPLSNGSAAS
Length1672
PositionTail
OrganismLeersia perrieri
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Leersia.
Aromaticity0.07
Grand average of hydropathy-0.222
Instability index48.93
Isoelectric point8.50
Molecular weight183482.97
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03332
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.89|      17|      24|     753|     769|       1
---------------------------------------------------------------------------
  635-  651 (32.32/19.96)	DRPPRKSGTDEP.LPSRP
  753-  769 (33.65/21.14)	DGPSRKRSLSEF.LPNIP
  778-  795 (26.93/15.23)	DGPSKRRKVSEFmLDGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      15|      16|    1124|    1138|       2
---------------------------------------------------------------------------
 1124- 1138 (25.94/14.70)	GPANNSSSSTVPNMS
 1142- 1156 (23.18/12.25)	GAAVAHSNSHLQTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      14|      17|     922|     935|       3
---------------------------------------------------------------------------
  922-  935 (23.86/14.13)	GSGVRVA.NTSEVDS
  941-  955 (19.58/10.28)	GDGILLTyDTVEADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      18|      23|     682|     703|       5
---------------------------------------------------------------------------
  684-  701 (31.61/24.46)	QVGLHGVRGGAGSPDQDY
  705-  722 (28.84/ 7.66)	QSNINSANGTSGVSMNNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.03|      28|     118|    1083|    1114|       7
---------------------------------------------------------------------------
 1083- 1114 (44.53/32.32)	IRLTAGPLLALcgaiRPAKMPVTVPSSYTALP
 1203- 1230 (55.49/30.16)	LRCFAGDQVWL....QPATPPKGGPSVGGSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.03|      23|      24|     413|     435|      10
---------------------------------------------------------------------------
  413-  435 (39.10/24.22)	KNVQMSQSP...TEVILKREVHGEGF
  437-  462 (33.92/20.09)	KKVRIGGSDdccTNEMLQVRAYGQSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      18|     118|     888|     914|      11
---------------------------------------------------------------------------
  866-  883 (35.51/19.37)	ASSNLW.LRLPFAH.DASWK
  892-  911 (28.03/22.95)	AGSMSWdVRINDPHyGALWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.28|      35|     675|     557|     594|      12
---------------------------------------------------------------------------
  557-  594 (52.71/50.98)	CANAYYLLM....QLDNSFKPAfcLLEIQsNEGDKNNADATT
 1231- 1269 (61.57/44.49)	CPQFRPFIMehvaQGLNAFEPN..LLNAR.HPGPQLNASFNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.91|      37|    1021|     278|     317|      13
---------------------------------------------------------------------------
  278-  317 (54.24/44.90)	TNALRQGrwKDAIKSELISDIhSGAGQGGNNALMQLGQDG
 1303- 1339 (66.68/41.27)	TSTSRAG..NAMMASGFASGI.PGAPAHLSPGNLGLGDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.34|      26|    1346|     218|     243|      16
---------------------------------------------------------------------------
  218-  243 (45.85/26.82)	HMELLVGEKTGPIKFEETRRYALGDD
 1565- 1590 (49.49/29.50)	HMSISGGAAWLPYCVSVRLRYTFGDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.72|      36|      59|    1440|    1475|      18
---------------------------------------------------------------------------
 1440- 1475 (62.37/44.08)	QSNGQEELTPSDISEICDYFSRRVASEPYDASRVAS
 1502- 1537 (62.36/44.08)	QAHGDNGTTQRARIELCLEKHPRLVSDDYTASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.93|      19|      24|     983|    1001|      20
---------------------------------------------------------------------------
  983- 1001 (29.03/19.67)	KLDDKIVKTLTAAETKLHS
 1009- 1027 (30.91/21.43)	RLSEQMRKTFRIEAVGLMS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03332 with Med14 domain of Kingdom Viridiplantae
Unable to open file!