<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03332

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEILHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLETSLPKEISEVSVTDGIANVKVDGEFKVLITLGYRGHFSLWRILHMELLVGEKTGPIKFEETRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNALRQGRWKDAIKSELISDIHSGAGQGGNNALMQLGQDGELDSSGSRIPGLKISYWLEEKSALAESDSSPFIKIEAGQDMKIKCQHSSFVLDPFTDKEAGLLIDPSRIDVEALILKAIACNRHTRLLEIQRELIKNVQMSQSPTEVILKREVHGEGFQKKVRIGGSDDCCTNEMLQVRAYGQSYIQLGINIRNGRFLLQSPGNILPPSAVSDSEEALNKGSATATDVFVSLRTRSILHLFAATASSLGLKVYSQSQVTLKIPKSILYGSDFMVMGFPQCANAYYLLMQLDNSFKPAFCLLEIQSNEGDKNNADATTDAKDTIRFIRIDINKLKIDEDVQIANFFDKDKLLALQNAEDRPPRKSGTDEPLPSRPSFSSVVDEVFVCDRGSPTTESQGFPFSSHSSYQVGLHGVRGGAGSPDQDYGSLQSNINSANGTSGVSMNNYLQSNSKHVQSTIAFSGSVPAGSGNISSSHSDGPSRKRSLSEFLPNIPSLKQYKIGDGPSKRRKVSEFMLDGLPLRASPNMQPGKILTYGKLLEEVNNCITANIYSSVLLHVIKHCSICIKYAQLTAQMDSLNISYIEEVGVQTASSNLWLRLPFAHDASWKHICLRLGKAGSMSWDVRINDPHYGALWKLYGGSTTTGWGSGVRVANTSEVDSHISFDGDGILLTYDTVEADSIQRLVLDLQRLSNARAFSCGMRRLIGVKLDDKIVKTLTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEVASFLDCIRLTAGPLLALCGAIRPAKMPVTVPSSYTALPKQNNILTTVGPANNSSSSTVPNMSVPQGAAVAHSNSHLQTSSMLSAAGRTTPGPPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDLRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPNLLNARHPGPQLNASFNTASGSQQSAPTTPNRFGGAPGVARPTSSVGNQVATSTSRAGNAMMASGFASGIPGAPAHLSPGNLGLGDDGSYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRIQLLLQVLNVKRFHHQQQQQQQTPQSNGQEELTPSDISEICDYFSRRVASEPYDASRVASFITLLTLPTSVLREFIKLIAWKKSFTQAHGDNGTTQRARIELCLEKHPRLVSDDYTASSSSSKSNIHHDRANSSVEFALTFVLDQGLVPHMSISGGAAWLPYCVSVRLRYTFGDNSHIVFLAMDGSHSGRACWLQNEDWERCKQKVARAVETMNGSAAIGDMSQGRLRMVAEMVQKQLQLSLLQLRDGPLSNGSAAS
Length1672
PositionTail
OrganismLeersia perrieri
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Leersia.
Aromaticity0.07
Grand average of hydropathy-0.222
Instability index48.93
Isoelectric point8.50
Molecular weight183482.97
Publications

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions

Repeat regions

Repeats

>MDP03332
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.89|      17|      24|     753|     769|       1
---------------------------------------------------------------------------
  635-  651 (32.32/19.96)	DRPPRKSGTDEP.LPSRP
  753-  769 (33.65/21.14)	DGPSRKRSLSEF.LPNIP
  778-  795 (26.93/15.23)	DGPSKRRKVSEFmLDGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      15|      16|    1124|    1138|       2
---------------------------------------------------------------------------
 1124- 1138 (25.94/14.70)	GPANNSSSSTVPNMS
 1142- 1156 (23.18/12.25)	GAAVAHSNSHLQTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.44|      14|      17|     922|     935|       3
---------------------------------------------------------------------------
  922-  935 (23.86/14.13)	GSGVRVA.NTSEVDS
  941-  955 (19.58/10.28)	GDGILLTyDTVEADS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      18|      23|     682|     703|       5
---------------------------------------------------------------------------
  684-  701 (31.61/24.46)	QVGLHGVRGGAGSPDQDY
  705-  722 (28.84/ 7.66)	QSNINSANGTSGVSMNNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.03|      28|     118|    1083|    1114|       7
---------------------------------------------------------------------------
 1083- 1114 (44.53/32.32)	IRLTAGPLLALcgaiRPAKMPVTVPSSYTALP
 1203- 1230 (55.49/30.16)	LRCFAGDQVWL....QPATPPKGGPSVGGSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.03|      23|      24|     413|     435|      10
---------------------------------------------------------------------------
  413-  435 (39.10/24.22)	KNVQMSQSP...TEVILKREVHGEGF
  437-  462 (33.92/20.09)	KKVRIGGSDdccTNEMLQVRAYGQSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.54|      18|     118|     888|     914|      11
---------------------------------------------------------------------------
  866-  883 (35.51/19.37)	ASSNLW.LRLPFAH.DASWK
  892-  911 (28.03/22.95)	AGSMSWdVRINDPHyGALWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.28|      35|     675|     557|     594|      12
---------------------------------------------------------------------------
  557-  594 (52.71/50.98)	CANAYYLLM....QLDNSFKPAfcLLEIQsNEGDKNNADATT
 1231- 1269 (61.57/44.49)	CPQFRPFIMehvaQGLNAFEPN..LLNAR.HPGPQLNASFNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.91|      37|    1021|     278|     317|      13
---------------------------------------------------------------------------
  278-  317 (54.24/44.90)	TNALRQGrwKDAIKSELISDIhSGAGQGGNNALMQLGQDG
 1303- 1339 (66.68/41.27)	TSTSRAG..NAMMASGFASGI.PGAPAHLSPGNLGLGDDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.34|      26|    1346|     218|     243|      16
---------------------------------------------------------------------------
  218-  243 (45.85/26.82)	HMELLVGEKTGPIKFEETRRYALGDD
 1565- 1590 (49.49/29.50)	HMSISGGAAWLPYCVSVRLRYTFGDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.72|      36|      59|    1440|    1475|      18
---------------------------------------------------------------------------
 1440- 1475 (62.37/44.08)	QSNGQEELTPSDISEICDYFSRRVASEPYDASRVAS
 1502- 1537 (62.36/44.08)	QAHGDNGTTQRARIELCLEKHPRLVSDDYTASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.93|      19|      24|     983|    1001|      20
---------------------------------------------------------------------------
  983- 1001 (29.03/19.67)	KLDDKIVKTLTAAETKLHS
 1009- 1027 (30.91/21.43)	RLSEQMRKTFRIEAVGLMS
---------------------------------------------------------------------------




Explaination for Stockholm format The "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space.

#=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00)

#=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column. It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column. This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.

#=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.

Alignment of MDP03332 with Med14 domain of Kingdom Viridiplantae

Intrinsically Disordered Regions

IDR SequenceStartStop
1) GLHGVRGGAGSPDQDYGSLQSNINSANGTSGVSMNNYLQ
2) GPQLNASFNTASGSQQSAPTTPNRFGGAPGVARPTSSVGNQVATST
686
1260
724
1305

Molecular Recognition Features

MoRF SequenceStartStop
NANANA