<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03275

Description Mediator complex subunit 25
SequenceMATFPAALNRPARVRAQRRRISAHSAVSAAAAVAVAATARGMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTENLVQQIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQPPTDVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length788
PositionUnknown
OrganismChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Chlorocebus.
Aromaticity0.05
Grand average of hydropathy-0.227
Instability index60.57
Isoelectric point9.23
Molecular weight82307.58
Publications









Function






Annotated function


GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03275
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     316.19|      48|      60|     655|     702|       1
---------------------------------------------------------------------------
  230-  276 (45.81/ 6.14)	PALR.LLFEKAA.....P...PAlLEPL...QPPTDV..SQDPRHmvlvrGLVL.PVG..GG....SA
  277-  323 (52.10/ 8.01)	PG....PLQPKQP...VP..lPP.AAPS...GATLSA..A.PQQP.....LPPVPPQYqvPGnlsaAQ
  645-  684 (79.07/16.00)	.Q.......PQPQGTAQP...PP.GAPQ...GPPGTA..SGPPPP.....GPILRPQN..PG....AN
  685-  729 (69.90/13.28)	PQLRSLLLNPPPPQTGVP...PP.QASLhhlQPPGAP..ALLPPP..........HQG..LG.....Q
  730-  775 (69.31/13.11)	PQLGPPLLHPPPAQS.WPaqlPP.RAPL.....PGQMllSG.GPR.....GPV..PQ...PG....LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.19|      16|      26|     364|     389|       3
---------------------------------------------------------------------------
  364-  379 (35.76/ 6.47)	APAPPL.PPGPPGAPKP
  392-  408 (24.43/13.20)	APGSGLaPTAQPGAPSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.62|      22|      25|     505|     528|       4
---------------------------------------------------------------------------
  505-  528 (34.11/31.31)	LFrnSRMVQF.HFTNKDLESLKGLY
  534-  556 (37.50/26.60)	GF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.82|      31|     110|      80|     110|       5
---------------------------------------------------------------------------
   80-  110 (58.34/31.72)	YLLPAIEYFNGGPPAETDFGGDYG..GTQYSLV
  192-  224 (50.47/26.48)	YLLPAVESTTYSGCTTENLVQQIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.80|      16|      24|     428|     451|       6
---------------------------------------------------------------------------
  414-  429 (31.46/12.78)	PGG...VSGPSPAQ...LG..A...PA
  430-  456 ( 9.35/18.73)	LGGqqsVSNKLLAWsgvLEwqEkpkPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.83|      26|      33|     577|     602|      10
---------------------------------------------------------------------------
  577-  602 (44.09/28.73)	GIRQVITNHKQVQQQKL.....EQQQRGMGG
  608-  638 (37.74/23.29)	GLGPILEDQARPSQNLLqlrppQSQPQGTVG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03275 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAAPSGATLSAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPITPLQQAAPGVGPPFSQAPAPPLPPGPPGAPKPPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQQRGMGGQQAPPGLGPILEDQARPSQNLLQLRPPQSQPQGTVGASGATGQPQPQGTAQPPPGAPQGPPGTASGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
273
585
431
786










Molecular Recognition Features






MoRF SequenceStartStop




1) LMDLI
784
788