<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03254

Description Mediator of RNA polymerase II transcription subunit 15
SequenceQSSWGTQATQRAGNRGQLATQYEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRMAQLQLQQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
Length787
PositionTail
OrganismChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Chlorocebus.
Aromaticity0.03
Grand average of hydropathy-0.716
Instability index86.71
Isoelectric point9.59
Molecular weight86463.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03254
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     290.54|      42|      43|     176|     217|       1
---------------------------------------------------------------------------
  176-  217 (79.53/17.57)	L.......QQQQQQQQQQFQ..AQQSAMQQQF.QA..VVQQQQQQLQQQQQQQQ
  219-  263 (53.62/ 8.72)	LiklhhqnQQQIQQQQQQLQrmAQLQ.LQQQ........QQQQQQQQQQQQQQA
  264-  297 (59.33/10.67)	L.......QAQP.......P..IQQPPMQQPQ.PP..PTQALPQQLQQMHHPQ.
  298-  326 (46.78/ 6.38)	......................HHQPPPQPQQ.PP..VAQNQPSQLPPQSQTQP
  327-  367 (51.28/ 7.92)	L.......VSQAQALPGQML..YTQPPLK..FvRApmVV..QQPPVQPQVQQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.55|      16|      19|     437|     455|       2
---------------------------------------------------------------------------
  121-  136 (28.39/ 6.20)	PMSLSGQP...P.PGTSGMA
  444-  463 (26.16/11.44)	PQSMPPPPqpsPqPGQPGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.02|      16|      19|     476|     492|       3
---------------------------------------------------------------------------
  419-  437 (18.36/ 6.55)	QP.MAQV....SQSSlPmlsSPSP
  486-  505 (24.49/ 7.06)	QPSQSPVtartPQNF.S...VPSP
  718-  733 (26.17/ 8.14)	PPLELSV....PADY.P...AQSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.62|      29|      34|     532|     562|       4
---------------------------------------------------------------------------
  532-  562 (40.72/32.87)	LDKLKQLSKYIePLRRMiNKID.KNEDRKKDL
  569-  598 (46.90/28.48)	LDILTDPSKRC.PLKTL.QKCEiALEKLKNDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.12|      43|      45|     628|     672|       5
---------------------------------------------------------------------------
  599-  642 (53.19/33.42)	....AVPTPP.PPPVPPTKQqylcQPLLDAVLANIRSpVFNHSLYR...TFV
  643-  689 (66.12/41.81)	PAMTAIHGPPiTAPVVCTRK....RRLEDDERQSIPS.VLQGEVARldpKFL
  694-  716 (30.81/12.45)	PSHCSNNG...TVHLIC........KLDDKDLPS..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.18|      18|      19|      80|      97|       7
---------------------------------------------------------------------------
   80-   97 (33.40/15.96)	PMNALQSLTGGPAAGAAG
  102-  119 (35.78/17.58)	PRGPGQSLGGMGSLGAMG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03254 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTAT
2) PLKFVRAPMVVQQPPVQPQVQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAVPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPIQQPPMQQPQPPPTQALPQQLQQMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPG
4) QSSWGTQATQRAGNRGQLATQYEDAMRKAGVAHSKSSKDMESHVF
69
344
257
1
147
537
336
45










Molecular Recognition Features






MoRF SequenceStartStop




1) HIRAR
395
399