<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03253

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLDAEWTQISTRYLREQLAKISDFYHMASSMGDGPVPVPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSLSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGNADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQHQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQPPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2149
PositionKinase
OrganismChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Chlorocebus.
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index58.37
Isoelectric point7.90
Molecular weight240552.44
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03253
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     695.50|     148|     150|    1813|    1961|       1
---------------------------------------------------------------------------
 1579- 1722 (146.37/55.14)	......LINGT...LAS..DLSNASPGG..S...EENKRAY..MNLVKKLKKELGDK..RS.ESIDKVRQLLPL..................PkqtcdvitcepmgslidtkgnkiagFDSIDK.KQGLQVSTKQKVSPW.DLFEG..QKNPAPLSWAWFGTvrvdRRVIKYEEQH.....hLL..LYHTHPMP
 1723- 1824 (147.67/55.68)	KPRSYYLQPLP...LPP..EEEEEEPTSpvSQEPERKSAEL..SD...........................QGKTTTDEEKKTKGRKRKTK............................................SSSRVDEYP.QSNIYRVPPNYSPISS....QMM......HHpqST.LW..GYNLMGQP
 1825- 1977 (248.15/100.79)	QQPGFFLQNQS...LTP..GGSRLDPAG..SFVPTNTKQAL..SNMLQRRSGAMMQP..PSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRP.........................FQQGQPgDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGT....QMPLQQTSQHQagSV.VLspSYNSRAYP
 1994- 2101 (153.31/58.06)	QQPSGYVQQQAspyLQPltGSQRLN............HQALqqSPLVGGGIDAVLTSahPNLPSVPLPQDPMRPRQPQVRQQQRLL.................................QMQQP.QQ...........PQ.PQPPP.....................QP.QQSSQPQ..SQ.TL..GLQAM.QP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     332.16|     128|     150|    1057|    1206|       2
---------------------------------------------------------------------------
 1066- 1218 (188.11/148.59)	HVWGF..NDVLCTVDVS..DLSFHDsLATFIAILIARQcfslEDVVQH.VALPSLLaaaCGDAD..AEPG.ARMTCRLLLHLFrapqaCFlPQATGKPFPGIRSSCDRHLLAAAHNSIEV.............GavfavlkaIMMLGDAKIGNNSVSSLKNDdftMRGLRCDGN
 1221- 1307 (94.76/47.63)	DIWTAsqNPKSCGKSISieTANLRE.YARYVLRTICQQ....EWVGEHcLKEPERL...CTDKEliLDPVlSNMQAQKLLQLI.....CY.PHGIKECTEG.........................................................................
 1340- 1411 (49.29/18.85)	............................................................................................QCLKDPGSGSVAEMNNLLDNIAKATIEVfqqsadlnnssnsG........MSLFNPNSIGNADTSSTRQN..gIKTFLSSSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|     150|     895|     911|       4
---------------------------------------------------------------------------
  866-  882 (22.97/ 7.00)	LLLKSSSLAGSYtTGLC
  896-  911 (29.21/13.50)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.23|      18|     203|     712|     733|       6
---------------------------------------------------------------------------
  712-  733 (29.71/25.49)	HFPIPLDESSSHECnqrtILLY
  916-  933 (35.52/19.92)	HVVNPSECSSPERC....ILAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.80|      24|      27|    1475|    1498|      15
---------------------------------------------------------------------------
 1475- 1498 (39.02/25.59)	VLTCL...KGQDE..QREGLLTSLQNQVN
 1500- 1528 (30.78/18.36)	ILSNWreeRYQDDikARQMMHEALQLRLN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03253 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAMMQPPSLHAI
2) QQRLLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQHQAGSVVLSPSYNSRAYPAAHSNPVLMERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQPPPQPQQSSQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
3) RSYYLQPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLMGQP
1826
1895
1725
1878
2149
1824










Molecular Recognition Features






MoRF SequenceStartStop




NANANA