<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03246

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSASFVPNGASLEDCHCNLFCLADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASIRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLRTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTPGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESGNSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2174
PositionMiddle
OrganismChlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Chlorocebus.
Aromaticity0.08
Grand average of hydropathy-0.393
Instability index53.16
Isoelectric point5.38
Molecular weight239428.51
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03246
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.79|      35|     421|     552|     589|       1
---------------------------------------------------------------------------
   31-   57 (42.61/13.74)	.....KKYVWQGPTSAPILFP.VTEEDPI..LS.SF
  552-  586 (66.62/34.56)	PSTPQSQHFYQMPTPDPLVPS.KPMEDRIDSLSQSF
  618-  648 (44.56/17.15)	YKVPKKKDVEFLP...PQLPSdKFKDDPVGPFGQ..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.38|      27|      27|    1494|    1520|       2
---------------------------------------------------------------------------
 1494- 1520 (44.10/27.69)	TNTGNANTPSATLASAASSTMTMTSGV
 1524- 1550 (38.70/23.21)	TSVATANSTLTTASTSSSSSSNLNSGV
 1552- 1572 (27.58/13.96)	SNKLPSFPPFGSMNSNAAGSM......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     139.65|      29|      31|     952|     980|       3
---------------------------------------------------------------------------
  952-  980 (52.86/27.38)	SSG...SAMPFIKEGDGSNMDQE.YGPAY.TPQT
  983- 1014 (40.88/19.32)	SFGmppSSAPPSNSGAG.ILPSP.STPRFpTPRT
 1021- 1050 (45.90/22.70)	PRG...AGGPASAQGSVKYENSDlYSPAS.TPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     278.37|     103|     422|    1595|    1727|       4
---------------------------------------------------------------------------
   98-  167 (83.28/42.41)	.............................................................DLSEEEDGVWENGLsYECrtllFKAVHNLLERCLMNRNFVRI..GKWFVKPYEKDEKPINkSEHLSC.SFTFF
  864-  905 (36.94/10.37)	PGgtvLEGNSSSIGAQFKIEVDEGFCS.PK...PSEIKDFSYVYKP........................................................................................
 1595- 1719 (158.15/178.34)	PG...ISGESSSLPTQPHPDVSESTMDrDKvgiPTDGDSHAITYPPaivvyiidpftyentDESGNSSSVWTLGL.LRC....FLEMVQTLPPHIKSTVSVQIipCQYLLQPVKHEDREIY.PQHLKSlAFSAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     293.10|     130|     424|     245|     398|       5
---------------------------------------------------------------------------
  250-  320 (71.85/59.36)	...............................................................................................................................................................................................................................................................................................................................................................................................................SEEKQEDMDWEDDSLAAVEVLV...AGVRMIYPAcfvlVPQsDIPTPSPvGSTHCSSSCLGVHQVPASIRD.PAM
  321-  391 (72.45/61.49)	SSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVsDGFNSDSTS..HHGGKIPRKLANHVVDrvWQECNMNraqNK.................................................................................................................................................................................................................................................................................................................................................................................................................
  718-  786 (66.77/30.74)	.........................................................................rkysassgglceevtaakvaswdfveatqrtncsclrhknlksrnagqqgqapslgqqqqilpkhktnekqeksekpqkrpltpfhhrvsvsddvgmdtdsasqrlvisapdsqvrfsnirtndvaktpqmhgtemanspqppplsphpcdvvdegvtktpstpqsqhfyqmptpdplvpskpmedridslsqsfppqyqeaveptvyvgtavnleedeaniawkyykvpkkkdveflppqlpsdkfkddpvgpfgqesvtsvtelmvqckkplkisdelvqqyqiknqylsaiasdaeqepkidpyafvegdeeflfpdkkdrqnSEREAGKKHKVEDGTSSVTVLSheeDAMSLFSPS....IKQ.DAPRPAS.HARPPSTSLIYDSDLAVSFTDlDNL
  789-  855 (82.04/41.04)	SDEDELTPGSKKSANGSDDKTSCKESKTGNL.DPLSCISTAdlHKMYPTPPSLEQHIMG..FSPMNMN...NK.................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      26|    1328|    1349|       6
---------------------------------------------------------------------------
 1328- 1349 (42.16/26.25)	P..EPLPIPTFLLGYDYDYLVLSP
 1353- 1376 (36.97/21.99)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.41|      45|     533|    1222|    1310|       7
---------------------------------------------------------------------------
 1260- 1310 (76.58/123.18)	CL.HP..WskrndVSMQCSqDILRMLLSLQPVLQD....AIQKKRTVRPWGVQGPLTW
 1795- 1846 (69.83/29.90)	CLsHDqrW.....ILASCT.DLYGELLETCIINIDvpnrARRKKSSARKFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.68|      26|      28|    1098|    1125|       9
---------------------------------------------------------------------------
 1100- 1125 (49.59/36.02)	MNIK.GADVGVYIPDPTQEAQYRCTCG
 1130- 1156 (42.09/22.05)	MNRKfGNSSGLFLEDELDIIGRNTDCG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03246 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
2) CLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
3) GSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHE
4) NLFNSDEDELTPGSKKSANGSDDKTSCKES
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTPGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
6) VAPTSQSLITPPQMTNTGNANTPSATLASAA
956
426
2021
785
1531
1480
1039
587
2053
814
1629
1510










Molecular Recognition Features






MoRF SequenceStartStop




NANANA