<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03237

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAAEYDTNILVVNNIASISFRVYEPSSDQSSSFGLAAIDIENSLREKGHIVYYDASRRGIWHFRIVGKEGSDEVSSQELDSSLSLRGYSLIVGEEGSFEPSSLPRPRSQQPQTGHTPTSSTSSASALDQSQRYAPTATSHLGPPGLQEQDSKGYTSVTDAKLVQGGSSSPKAYESFVVATLLTIQSAFCRHTDSIPLNYRTVLLSQDILENDGSFDVLTEKTPTIGTFSAYLTTTGVLVVCMGISICRGSLSYGDMLNQAPDIPGQQILAAPFGVIASNQPAAQFDGGTASMAQTPNTQALSLRGAPDIHNSLWKQACLKFLQLRGVAQSKLTDCFWINLLISKPKLQDAKSDVKRSPMPNSTVTIPWPSPLCFRKRPVEVSSTSRVGETILRGHEESHDPLGNAQSWFSSTPERDEKISKRKAERVATSSEGFGGDSRPTRLNGQSPLTLRRPSTAAAGSMYPTPPDALQNANGVTPSLDGTLSSPGNPLSAAAVPEVDNNGSVSMAMGDSFEPVRDFSESKRQRSDSNLLGEADHMFGDMGQDMFGDNDITEADFNFFDEEPEDIDLEAALDEMGDATTAAIIGAEEHTADEEISNSREPIKEEPETEKDAGGFTKPELCHAISVQNNHAMPRGRESRPVSMKRESSPFDPHTVFKRVCASLAATEKDGTIATDASRMTKIFEKMDFDPTLPMINKKYEQGGQFDYSMSTAVGNSRLDHGVLPETDYLKRHGKLHRGSQEHKLYTKSLMGPLSGLERPISGRSPTKLDTQMSDDEQSSTESDQDDSSYTSDEPTSPPKSSVKQAPVEEDAVSQVTSLKEQDVIEEPDHQLAIELPRLSKPETPELPLSMLFSDPEPLALELSLGDEDLIQAAQILTEQAATGSLDLCNTDRPANTSIISQGRATLLSDSRTALQQLREALSVFLRGVEPVRLKAFLDIQDVLLQGQPRMQPRPIPGRDANAEQIRPSNLYQIPGPHLEVRRSDAKLSVLPSAVAFWESLGLAPSSGSKDITAVCVFPGWKGMADNVKTFLGRIKSVYEVLRLGSFENMALASDMDSGVLPYEMDRISTSPDATLTGHGSALIGTMETLRASLSNLTVSDTNVVVYFVYSPNNPGTIVEACAAFQRFFDSYQKDLAAKKETATNELVLQLVSSDLLSSPTSVVVTPSVDLVRLCMETYDRCTLFGGPMPAPAIRLEQPLPRIIDFKLNTQPSMSLIRENSCIHVAYAQTVDGRWVTTAWTDDRGNQQATASYCLGRKGRPLSTSMSEVAYEIWQSTLDLISAWTVHWRVIITKCGPMDQQEIDSWVNLAHTETRLQVTMILMTVDTDPWLQLVPPVVKLPHASVPFYTTPVSTPQANIVSPEQSATPATPANLTAATPGGGEAGADTETDAILADVTDQTWGAIVGHRLNNSLGVTDLYPALVSGFLIKRTGARAEDVPIAMEVNLIHTEAFPRSYEPLLREMLSYFRGLATLSRARGMVSRETDVRPWHIAAAEKASRAMYLLM
Length1507
PositionKinase
OrganismMetarhizium anisopliae BRIP 53293
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.06
Grand average of hydropathy-0.349
Instability index51.83
Isoelectric point4.93
Molecular weight164054.19
Publications
PubMed=25102932

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP03237
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.52|      34|      36|     519|     554|       1
---------------------------------------------------------------------------
  499-  516 (21.34/10.81)	................EVDNN.GSVSMAM.GDSFEP
  519-  554 (52.20/52.23)	DFSESKRQRSDSNLLGEADHMfGDMGQDMfGDNDIT
  557-  579 (31.98/20.37)	DFNFFDEEPEDIDLEAALDEM.GD............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.55|      36|      37|     369|     405|       3
---------------------------------------------------------------------------
  360-  402 (56.32/46.04)	MPNstvtipWPSPLCFRKRPVEVSSTSRVGeTILRGHEESHDP
  403-  441 (57.23/41.49)	LGN...aqsWFSSTPERDEKISKRKAERVA.TSSEGFGGDSRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.27|      22|      37|     601|     630|       4
---------------------------------------------------------------------------
  601-  623 (34.69/33.08)	RE..PIKEEPETEK.DAGGFTKpELC
  638-  662 (31.58/10.95)	REsrPVSMKRESSPfDPHTVFK.RVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      16|      37|     258|     273|       5
---------------------------------------------------------------------------
  258-  273 (27.91/15.94)	LNQAPDIPGQQILAAP
  293-  308 (27.53/15.61)	MAQTPNTQALSLRGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.56|      16|      25|      57|      74|       7
---------------------------------------------------------------------------
   57-   74 (26.49/23.76)	SRRGiwHFRIVGKEGSDE
   85-  100 (30.08/18.19)	SLRG..YSLIVGEEGSFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.02|      21|     362|     880|     900|       8
---------------------------------------------------------------------------
  880-  900 (37.84/22.40)	EQAATGSLDLCNTDRPANTSI
 1247- 1267 (39.18/23.45)	NQQATASYCLGRKGRPLSTSM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03237 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GQFDYSMSTAVGNSRLDHGVLPETDYLKRHGKLHRGSQEHKLYTKSLMGPLSGLERPISGRSPTKLDTQMSDDEQSSTESDQDDSSYTSDEPTSPPKSSVKQAPVEEDAVSQVTSLKEQDVIEEPDHQLAIELPRLSK
2) GSFEPSSLPRPRSQQPQTGHTPTSSTSSASALDQSQRYAPTATSHLGPPGLQEQDSKGYTSVTDAK
3) NDITEADFNFFDEEPEDIDLEAALDEMGDATTAAIIGAEEHTADEEISNSREPIKEEPETEKDAGGFTKPELCHAISVQNNHAMPRGRESRPVSMKRESSP
4) QANIVSPEQSATPATPANLTAATPGGGEAGADTETDAI
5) TSRVGETILRGHEESHDPLGNAQSWFSSTPERDEKISKRKAERVATSSEGFGGDSRPTRLNGQSPLTLRRPSTAAAGSMYPTPPDALQNANGVTPSLDGTLSSPGNPLSAAAVPEVDNNGSVSMAMGDSFEPVRDFSESKRQRSDSNLLGEADHMFGDMGQDMFG
705
97
551
1357
385
842
162
651
1394
549










Molecular Recognition Features






MoRF SequenceStartStop




1) DITEADFNFFD
552
562