<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03227

Description Serine/threonine-protein kinase
SequenceMPLRMRNGPQYHHPSSASSHPFSASSAHHRYADTHDRPGAFHPRLRVMDRYRIVGFISSGTYGRVYKAVSRVSTVAVRTTTTPSGASSGSATAGQEVAIKKFKPDKEGEQISYTGISQSAIREMSLCSELRHHNVIRLVETLLEDKCIFMVFEYAEHDLLQIIHHHTQQPRHPIPPATIKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSGGEVKIGDLGLARRFDKPLHSLFSGDKVVVTIWYRAPELILGSYHYTPAIDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMQKIVDIMGIPTRSRWPLLPMMPEFNQLNTLQSPPSHHSHHHHHHQHHSHSSSSSSTSNLEKWYYNTISNAPQSASSGPSLTSLGAEGYKLLAGLLEYDPTKRLTAAQALQSTFFTTGDRVNTNAFEGLKVEYPHRRVSQDDNDIRTSSLPGTKRSGLPDDSLLRPPKRVKE
Length472
PositionKinase
OrganismMetarhizium anisopliae BRIP 53293
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Metarhizium.
Aromaticity0.08
Grand average of hydropathy-0.489
Instability index43.19
Isoelectric point9.47
Molecular weight53051.62
Publications
PubMed=25102932

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03227
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.29|      23|     175|     150|     172|       1
---------------------------------------------------------------------------
  150-  172 (44.56/23.57)	MVFEYAEHDLLQII.......HHHTQQPRH
  321-  350 (40.73/21.00)	MMPEFNQLNTLQSPpshhshhHHHHQHHSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     264.26|      91|     321|      16|     126|       3
---------------------------------------------------------------------------
   16-  126 (130.94/150.23)	SASSHpfSASSAHHRYADT.HDRP..GAFHPRLRVM..DRYRIVgfisSGTYGrvYKAVSRVstvavrttTTPSGASSGSATAGQEVAIKKFkpdkEGEQISYTG..ISQ..SAIREMSL
  351-  450 (133.31/99.31)	SSSSS..STSNLEKWYYNTiSNAPqsASSGPSLTSLgaEGYKLL....AGLLE..YDPTKRL........TAAQALQSTFFTTGDRVNTNAF....EGLKVEYPHrrVSQddNDIRTSSL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03227 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AFEGLKVEYPHRRVSQDDNDIRTSSLPGTKRSGLPDDSLLRPPKRVKE
2) MPLRMRNGPQYHHPSSASSHPFSASSAHHRYADTHDRPG
425
1
472
39










Molecular Recognition Features






MoRF SequenceStartStop




1) LEKWYYNT
2) LPDDSLLRPPKRVKE
360
458
367
472