<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03222
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MDDSIDVDDLFGDPNSLELGLAASAPTWKSLSQRFDELRLSGCCRKLAWSKLGAIAYISNDGQKVFLQNILCNADDGEWSLCDGRFRCKIAEAQSGHTFIHLCWHESGSDLAIVDSCGRVMIVSMSIALNAFAVSRSIVIDPDDDGNQPVGLMWLGVNRPVHAFNKASKTNGRWVYSRYVRRPLGPFHPLNKSALVCVTRSGHIRLLYQSQDPKWNEVHVDLQTVSCSDDILTHAALSASQGGSILMVTYSTQHRLFVYRVHIKWDAAPVDTTQQQPVGFSVAQTPTIQITHIRTEIQRSVFQRADNDYERSPSARVMPVLTHLDIVGIASDGSAGSYVEPYILAAFAIPVSALETQRQFNGTSSIVRWALESTGQSTHSSFDEIPPKRQTFNLTPKTELTRWDDIHFDKRVLSIDYFEAGSVVSLTFDDGSISFYDAKTMNAISDNEDLATISITCISFSPNGCLAVTLDEDSELHLHVMEHSFGIEHGMYNDEQFGAAVAALALAFSHACSNDSSSDDVMMIAARSLTPDTRKTFITEVYHALSVNADFTIEQDKLMNNPYIQKCFSMQAALGFNGRLEQRNLAAAIPWFTLQLRQISILFAYFLHFNKSGSDSECHEPDILRMVLGNVRWALDLAKYLIDDLFEIASSFDKHSGDQSDKKLESFSMLLVLSSIPRAFLKYICRGLRGIPSSFRSATNLSNESFGVYSNIVRLIEESPLRVDVYEKFLLSIDNVIKYTYQNAGFGSTDRSTPERDLLITASVPPVLQPAVVTILTNTMTLIRPDVDLLHLCTWDYSWLGIDDDKLTRLFRRRNEVDILKKTITQLGEPQAKSKQPKRRCARCCAVSEDTTSPKSLASFRLLVKTVVLRTCICGGVWMVENLDTISRGPVSAWK |
Length | 895 |
Position | Tail |
Organism | Coccidioides immitis (strain RS) (Valley fever fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Onygenales> Onygenales incertae sedis> Coccidioides.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.117 |
Instability index | 45.70 |
Isoelectric point | 5.80 |
Molecular weight | 99875.32 |
Publications | PubMed=19717792
PubMed=20516208
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | |
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP03222
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 113.51| 38| 41| 589| 628| 1
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589- 628 (62.53/48.34) IPWfTLQLRQ..ISILFAYFLHFNK.SG..SDSECHEPDILrMVL
631- 673 (50.98/30.28) VRW.ALDLAKylIDDLFEIASSFDKhSGdqSDKKLESFSML.LVL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.83| 15| 41| 418| 432| 2
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418- 432 (25.07/16.08) FEAGSVVSLTFDDGS
460- 474 (26.76/17.67) FSPNGCLAVTLDEDS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 41.83| 11| 226| 164| 174| 3
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164- 174 (23.52/13.55) FNKASKTN.GRW
392- 403 (18.31/ 9.09) FNLTPKTElTRW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 117.46| 35| 125| 118| 152| 4
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118- 152 (60.64/38.37) GRVMIVSMSIALNAFAVSRSIVID..P.DDDGNQPVGL
243- 280 (56.82/35.51) GSILMVTYSTQHRLFVYRVHIKWDaaPvDTTQQQPVGF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 114.15| 36| 640| 30| 70| 5
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30- 70 (54.95/46.98) SLSQRFdelrLSGCCRKL..AWSKLGAIAYISNDGQKVFlQNI
675- 712 (59.19/36.42) SIPRAF....LKYICRGLrgIPSSFRSATNLSNESFGVY.SNI
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