<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03214

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMVADITPRENGISHVNGDATYTLEQLEAELPYVDDGMVYLGDLIQRVMQTIYTELSELAETMPNMSDGARKRTLADWVVKTKKQVTKLYAVTKWSRDAAVVQKCMNVIAFLLAQNVQFLACIDHLNSAREGLDPARLRNHDLLTSLDVLTTGTYKRLPTMLQAWVPIKPLTDAQVLKTFSDLEDAMRYRLRLTEFIPLEMSNYQITNGRVVFTVPHLFELTLGCTGSEPTDPWFFIDVEFLFNAVATGTQEFPRIPTGPTKRFITEEADLRLGQYVQAPPPADPMQDPNAPPPPRPGLPEGYVDAPLVRMYNFLRMMSLSYQLEILLYQAERMRSLGWAEYLRVQLSADRKTLSVSYWMRKPPPTNLSRAKQAELARIPLLAGTLTVSIVESDVDATARLSPRAKILAELQRKAKLGGQRPSEEVEGLSFRVTWDPEYRALGIDVHREDLSIAPEVLKVNHDDLDIQAILTNVIRQHTKALLLRQQSMLRADVEVFRAPGVVEVLDDDIAPSLRVRLCADEVVTVTIDPRTGLLTLRDTGDLASAGRGPRITAVTERLNEHPDMLRTALMKLRVLTLLDLAEHTAKYLGMECYRNRNFAGEPTPSHFARGMLYIHLDQFPGHYLTVVITDLEYRYALCATQLDPNPANVYGSLLLAEVAWLNYDRIHGTAEDVNDMETRAGMKRKRNTDSSMAVNQGHNLDAHVLRELYAYSCARVSYASVENQLKSRDIPFRHVSPVEMTVLPELQSSLARSVPGLCVQSHDILAGAPAAEAAMPNIRVIPLNWWSQDRSKKPQVVTCVKLKYVYIRGGGTGGIIRPSKRIIYDTTEAVVSFLSENVNTCVDEFLEEWARVSKMVVIARAVSQMDGGVRLLEFDLREVVFAYEADYTVAVRCVDQGSIGGGNASGSVFELKFGRIGGKWDDDNPHSRAEPFLRSVLHAGQLLAPSLRKLVQLLRSTLPIVKALVEEGADVFAKSAGWYRVLYHKGGRTHAVDYRLMTERRVAVLDGSQSLYHAPTPTPAQPSKVDGVGLTPIPGFGDIVRDLPGPGRKLDVSVVCMVEEVCQVAKEVHRRVLKEVDAQMES
Length1082
PositionTail
OrganismCylindrobasidium torrendii FP15055 ss-10
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Cylindrobasidium.
Aromaticity0.07
Grand average of hydropathy-0.169
Instability index35.62
Isoelectric point6.21
Molecular weight120915.52
Publications
PubMed=25683379

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03214
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     140.90|      32|      32|     352|     383|       1
---------------------------------------------------------------------------
  270-  315 (30.55/14.30)	.LRLGQ................YVQAPPPA.DpmqdpnapppprpgLP.EGYvDAPLVRMYNFLR
  316-  349 (19.59/ 6.48)	MMSLSYqleillyqaermrslgW...............................AEYLRVQLSAD
  352-  383 (57.91/33.85)	TLSVSY................WMRKPPPT.N..............LS.RAK.QAELARIPLLAG
  384-  418 (32.85/15.95)	TLTVSI................VESDVDATaR..............LSpRAKiLAELQRKAKLGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     117.13|      47|     165|     436|     507|       2
---------------------------------------------------------------------------
  436-  465 (21.02/52.39)	...........................PEYRAlGIDVHRE.DLSIApevlkVNH.DDLD
  481-  507 (19.53/12.73)	LLLRQQSMLRADvevfRAPGVVEVLDD................................
  653-  701 (76.58/52.89)	LLLAEVAWLNYD....RIHGTAEDVNDMETRA.GMKRKRNtDSSMA.....VNQgHNLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.54|      16|      30|      21|      36|       3
---------------------------------------------------------------------------
   21-   36 (29.17/21.25)	YT.LEQLEAELPYVDDG
   52-   68 (25.37/17.40)	YTeLSELAETMPNMSDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.87|      29|      31|     136|     166|       4
---------------------------------------------------------------------------
  136-  166 (44.68/36.55)	R.LRNHDLLTSLDVLTTGTYKRLptMLQAWVP
  168-  197 (43.19/27.80)	KpLTDAQVLKTFSDLEDAMRYRL..RLTEFIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.50|      31|      39|     573|     604|       5
---------------------------------------------------------------------------
  573-  604 (50.97/35.12)	RVLTLLDLAEHTAKYL.....GMEcYRNRNFAG..EPTP
  609-  646 (49.53/28.66)	RGMLYIHLDQFPGHYLtvvitDLE.YRYALCATqlDPNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.97|      29|      35|     712|     744|       8
---------------------------------------------------------------------------
  712-  744 (46.98/37.83)	SCARvsyaSVENQ.LKSRDI....PFRHVSPVEMTVLP
  749-  782 (40.99/23.67)	SLAR....SVPGLcVQSHDIlagaPAAEAAMPNIRVIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.58|      36|     431|     509|     558|       9
---------------------------------------------------------------------------
  509-  558 (52.28/55.20)	IAPSLRvRLCadevvtvtidprtGLL..TL.......RDTGDL..ASAG.......RGPRITAVTERL
  943-  996 (41.30/21.38)	LAPSLR.KLV.............QLLrsTLpivkalvEEGADVfaKSAGwyrvlyhKGGRTHAVDYRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.26|      14|      27|     206|     219|      10
---------------------------------------------------------------------------
  206-  219 (24.99/15.17)	TNGRVVFTVPHLFE
  230-  243 (27.27/17.19)	TDPWFFIDVEFLFN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03214 with Med14 domain of Kingdom Fungi
Unable to open file!