<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03209

Description CMGC/CDK/CDK8 protein kinase (Fragment)
SequenceMAALHEDWQTVLQQDPMRLYRTKRESTREFMRSRYNILGFISSGTYGRVYKASLPSDSQTFFAIKKFKPDKEGDVATYTGISQSAIREIALNREIDHDNVARLIEVILEDKSISMVFEYADHDFLKLIHHHSQTIRCQVSTQVLKSLTYQLLNGLVYLHACHILHRDLKPANILVTERGVVKIGDLGLARLIYEPLQPLFSGDKVVVTIWYRAPELLLGARHYHKAIDLWAVGCVIAEVGFLRPIFKGEEAKIDSKKNVPFQRDQLIKIFETVGTPDEVEWPGLVTMPDYNNMKRLDHFPHRLEAWCIKHLRQYPTIFDLLRELFTYDPDQRLTAANALQHKWFKEDPQPCWNAFENVSPTHIPPPRRITIEEGSNVVPVQTAHPPLAAAAPGPFPQSKPGSVASFGSMSGGTMYTQTGSTHPRKKAKYA
Length430
PositionKinase
OrganismCylindrobasidium torrendii FP15055 ss-10
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Cylindrobasidium.
Aromaticity0.10
Grand average of hydropathy-0.326
Instability index44.72
Isoelectric point8.75
Molecular weight49025.73
Publications
PubMed=25683379

Function

Annotated function 
GO - Cellular Component
euchromatin	GO:0000791	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi

GO - Biological Process
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03209
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.48|      13|      23|      58|      72|       2
---------------------------------------------------------------------------
   58-   72 (17.54/20.08)	SQTffAIKKFKPDKE
   82-   94 (20.94/13.98)	SQS..AIREIALNRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.49|      17|      25|     154|     178|       3
---------------------------------------------------------------------------
  154-  170 (31.78/30.71)	GLVY...LHACHILHRDLKP
  179-  198 (23.71/ 7.05)	GVVKigdLGLARLIYEPLQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03209 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPPPRRITIEEGSNVVPVQTAHPPLAAAAPGPFPQSKPGSV
363
403










Molecular Recognition Features






MoRF SequenceStartStop




1) HPRKKAKYA
422
430