<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03207

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLNVALLDADVSHVAYVVVSSALAQPIDVLRRNIYEKNADKPLVGSLHISVQVGVTTFMHIFRISQTGELDLLDGLDLSQVSVLESSSFTPHDIVSTAFPPTSLRSVVSHFFDALRSTLIDRVSRQSGVLARLRTGFLVCQDTTASTEWSAPWAVIRPLAFCHLQIHFAQSRLIVHPLIISTPFIPLAPSLPTGTPITLCPFGITAYYLASYHGPTNALSRQFQDLLVGLGVHAWNRDAFVVAWIVVENKQGDDKGVTVIYPRSLCVRAHPSKHPDLPCIPSIPATLEASPDAALPTPVMSPLSLSSASPNTFRTLTATKNRDLPSIANQIGQFVDDQAALRELERERLKREREGGPSSRNPSQIFAPAPDPTPAPPVYIAPQPVPIVPTPAIQVTQAPDNFYPSPPQTNTAAQPTPAAAAVSSPVMDVDPQPVQSMPYYDANWMDSFLAGTGEVNASSGMMMSGDDDFGGVGFTEDDFKFFDAKPDPNMSTGLTPAPNDNIWEAFGTGLPAVTPAFIPQSSPIHMPSPQKPPPPPETSFIMEDIRLAGRAASGQWDAIPFAPKYRSSDSKYSAGKFKSGLASPPAESERYYRRSTDPSLAMVKRLREKKGGLKGRITPTAQESEEEWMSVRSPVDSEEVEEESDEDMESESEEEDETGMTRPSTPLSGCMLSSPALLSMHFNHAYLLPQSSPLRQGMNSAAVGVNPVLSVPTPVSPGPAGKTKALELAVASLAREMVENVVWSDAWRDIHSTAVASVDIWDRDIAAVSTLLAGVDGVRAPLSMQDLFGLGPSDERFEKLEPPSFIVGKGEAVMQMSPPSLRFWDKLGLGPRSGRKDLRAFVAFDPNQQDLTHRVPEWMSALGRAYSSKQFGKVSPGVSEHCADGVVQLRFDSSLRKSLDTLAKGIPTPPPRTYNVVIIVLPLSALQRPQQLRQLFDVIVKTSKSLQTPLLFQLIPEQIMRGDFSTALPSLCLSLYDRLRVPVVRSMSRDLFNMGEMQKLIEDPAFVIARTAEETKMVLGPLKSGALGSVLDVGTFLHVAYSVSTCGNWLCMACVDQRGEAHDTGVRLTIQGGGGGDDDEDDTAFLVSTVWEFARKFARMATASWRVVIAKLGVMECAELEAWTVQLERVDEPIHVSVVCAEVGAPYMFTGRPAFAPPPAPGRAASVSTTKPSRTVMFMDVTATTYALYQATPLPVSVPPTLADLGLETHCIEEEGEEDGLEKYPHRLPLTPRATGTLIRVPSVGTTEMLHVHLLYGIHSEACAVPVATEAALVRDVTRSWYALSVLAAARMGEGCGILPYHLAAIERMRDAVRLVDVGPEGAPEP
Length1327
PositionKinase
OrganismCylindrobasidium torrendii FP15055 ss-10
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Physalacriaceae> Cylindrobasidium.
Aromaticity0.07
Grand average of hydropathy-0.098
Instability index54.81
Isoelectric point5.25
Molecular weight143814.34
Publications
PubMed=25683379

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03207
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     289.91|      95|     210|     675|     819|       1
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  381-  497 (147.11/69.21)	IAPQPVPIVPTPaiqVTQAPdnfypsppqtntAAQPTPAAAAVSSPVM.............DVDPQPVQSMPYYDANW..MDSFLAGTGEVNASSGMmmsgdDDFGGVGFTEDDF......KFFDAKPDPNMStgLTP
  704-  819 (142.80/143.17)	VGVNPVLSVPTP...VSPGP............AGKTKALELAVASLARemvenvvwsdawrDIHSTAVASVDIWDRDIaaVSTLLAGVDGVRAPLSM.....QDLFGLGPSDERFekleppSFIVGKGEAVMQ..MSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     252.91|      67|     210|     976|    1044|       2
---------------------------------------------------------------------------
  641-  687 (36.83/16.33)	..........................VEEESDEDmeseSEEEDETGMtrPSTPL.SGCMLSSPAlLSM....HFNHAY..
  976- 1044 (105.12/68.36)	LYDRLRVPVvrSMSRDLFNMGEMQKLIEDPAFVI....ARTAEETKM..VLGPLKSGALGSVLD.VGT....FLHVAYSV
 1189- 1259 (110.96/66.78)	LYQATPLPV..SVPPTLADLGLETHCIEEEGEED....GLEKYPHRL..PLTPRATGTLIRVPS.VGTtemlHVHLLYGI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     269.30|      85|     101|     125|     224|       5
---------------------------------------------------------------------------
  129-  224 (129.86/102.67)	GVLARLRTGFLVCQ...DTTASTEWSApwAVIRPLAFChLQIHFAQsrlivHPLIISTPFIP....LAP..SLPtgTPItLCPFGITAYYLASYHGPTNALSRQF
  232-  325 (139.44/82.63)	GVHAWNRDAFVVAWivvENKQGDDKGV..TVIYPRSLC.VRAHPSK.....HPDLPCIPSIPatleASPdaALP..TPV.MSPLSLSSASPNTFRTLTATKNRDL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03207 with Med13 domain of Kingdom Fungi
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