<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03161

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGAVVRRAAEDSYLALRELVEKSRVEAEGKNGQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLVHYCQQLASTLSSHETCFTQTADSLFFMHEGLQQARAPIFDVPSAIEVLHTGSYRRVPKCVEEIGTQNTLFQDEQKPTLKKLSTLVRAKLLEISLPKEISEVSVTDGIANVQVDGEFKVLITLGYRGHFSLWRILHMELLVGEKAGPIKLEEIRRYALGDDIERRMAVADNPFMILYTILHELCISLVMDTVIRQTNVLRQGRWKDAIKSELISDIGTGQGGSNAVMQLGQDGELDSSGSRIPGLKINYWLEEKNNASAESDSSPYIKIEAGQDMQIKCQHSSFVLDPFTDKEADLSIDLSCIDVEALILKAIACNRHTRLLEIQRELMKNVQMSQSPTEVILKREVHGEGFQKRVHRRDSNDCCTNEMLQVRAYGQSYIDLGINIRNGRFLLQSLGNILPPSAVLDSEEALNKGSTTATDVFVSLRTRSILHLFAATGSSLGLKVYSQSQVTLKIPKSILCGSEFMVMGFPQCANAYYLLMQLDKSFKPIQSNEGDNNNADATTDAKEAIRFIRIDINKLKIDEDVQIGNFFDKDKLLALQNVEDRPQRQSGADEPLPARPSFFSVVDEVFRCDRGSPITESQRLPPNSLPSSHSSYQVGLHGFSGGAGSPEQDYGSLQSNINAAKVTSGTGLNNYLLSNSKNAQSTSAFSGSVPAGLGNVSSSRSEGAYKKRSLSEFLQNIPSSKQSIIGDGPGKRRKLSEFMLDGLPLKANSPNMQPGTSLTYGKLLEELTAQMDSLNIPHVEEVGMPTSSSNLWLRLPFAHDASWKHICLHLGKAGSMSWDVRINDPHYGALWKLHGGSTTTEWGSGVRVANTSEVDSHISFDDDGVLLTYNTVEADSIQRLVSDLQRLSHARAFSCGMRRLIGVKLDGKLAEHQTAAETKLHSRRKASRDRLSEQMRKTFRIEAVGLMSLWFSYGAVPMVYFVVEWETGKSGCTMRVSPDQLWPHTKFLEDFVNGDEIASFLDCIRLTAGPLLALGGAIRPAKMPVTVPAGYSALPKQNNILTTAGSANSLSSSTMHNMSVPQGAAVAHSNSQLQTSSMLSVAGRTAPGLVPSSLLPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLNASANTVSGNQQLASAPNRFGGAPGVARSTSTVANQVASSLSRAGNAMMPSGFASGIAGAPAHLSPGNVPAHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPALRFFVGGYVFAVSVHRVQLLLQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYSASSSSSKSNIHHDRANNSVDFALTFVLDQALVPHMSISGGAAWLPYCVSVRVRYTFGEDSHIAFLAMDGSHSGRACWLQHEDWERCKQRVSRAVETMNGSAAVGDMSQGRLRMVAEMVQKQLQLSLLQLRDSPVSTGSAAS
Length1649
PositionTail
OrganismOryza barthii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Oryzoideae> Oryzeae> Oryzinae> Oryza.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index50.89
Isoelectric point7.60
Molecular weight180989.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03161
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.60|      36|     169|     660|     700|       1
---------------------------------------------------------------------------
  631-  660 (46.40/25.90)	RQSGADEP..LPARP.SFFS.VVDEVFRCDRGSP.............
  662-  699 (63.86/41.12)	TESQRLPPnsLPSSH.SSYQ.VGLHGFSGGAGSPEQD.......YGS
  842-  876 (28.35/11.03)	..........LPFAHdASWKhICLH..LGKAGSMSWDvrindphYGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.06|      15|      15|    1086|    1100|       2
---------------------------------------------------------------------------
 1086- 1100 (23.76/17.35)	NILTTAGSANSLSSS
 1104- 1118 (26.30/20.26)	NMSVPQGAAVAHSNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.18|      22|      23|     740|     762|       3
---------------------------------------------------------------------------
  715-  733 (30.22/11.55)	LNNYLLSN....SKNA...QSTSAFS
  740-  761 (38.12/17.77)	LGNVSSSR....SEGAYKKRSLSEFL
  763-  786 (25.84/11.27)	..NIPSSKqsiiGDGPGKRRKLSEFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.88|     102|     115|     180|     294|       4
---------------------------------------------------------------------------
  180-  292 (154.64/113.19)	ISEVSVTDGIAN..VQV..DGEfkvLITLGYR..G.HFSLWRILHMELLVGEKAGP.IKLEEirryalGDDIE...RRMAVADNPFMILYTILH.EL.CISlVMDTVIRQTNVLRQGRWKDaIKSE
  294-  408 (134.24/80.40)	ISDIGTGQGGSNavMQLgqDGE...LDSSGSRipGlKINYWLEEKNNASAESDSSPyIKIEA......GQDMQikcQHSSFVLDPFTDKEADLSiDLsCID.VEALILKAIACNRHTRLLE.IQRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.38|      58|      59|    1395|    1452|       5
---------------------------------------------------------------------------
 1395- 1452 (99.71/75.93)	LL.LQVLNVKRFHHQQQQQQQTPQNNGQEELTVPEISEICDYFSRRVASEPYDASRVAS
 1456- 1514 (92.67/69.95)	LLtLPISVLREFIKLIAWKKSLPQAHADNATTHRARIEICLEKHPRLVSDDYSASSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     321.03|     106|     146|    1121|    1228|       7
---------------------------------------------------------------------------
 1121- 1185 (88.38/57.02)	...............................................................................QTSSM.....................................................................................................................................................................LSVAGRT......APGL..VPSSLLPFDVSVVLRGPY....WIRIIYRNkfSVDMRCFAGDQVWLQPATPPK
 1186- 1330 (153.26/94.78)	GGPSVGGSL.PCPQFRPFIMEHVAQGLNALEPNLLNARHTGPPLnasantvsgnqqlasapnrfggapgvarststvanQVASS.....................................................................................................................................................................LSRAGNAmmpsgfASGIagAPAHLSPGNVPAHMKGEL....NTAFIGLG....DDGGYGGG..WVPLAALKK
 1334- 1377 (37.21/16.19)	GILKYLGVLwLFAQLPDLLKEILGSVLKDNEGALLNLDHEQPAL.....................................................................................................................................................................................................................................................................................
 1543- 1587 (42.17/20.06)	....................................................................................rffvggyvfavsvhrvqlllqvlnvkrfhhqqqqqqqtpqnngqeeltvpeiseicdyfsrrvasepydasrvasfitlltlpisvlrefikliawkkslpqahadnatthrarieiclekhprlvsddysasssssksnihhdrannsvdfaltfvldqalvphMSISG..........G.....AAWLPYCVSVRVRYTFgedsHIAFL.....AMD.GSHSGRACWLQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.64|      13|     163|     812|     831|       8
---------------------------------------------------------------------------
  787-  803 (19.39/12.11)	LDGLplkaNSPNMQP.GT
  818-  831 (20.25/10.08)	MDSL....NIPHVEEvGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.40|      12|      17|     892|     903|      10
---------------------------------------------------------------------------
  892-  903 (21.05/15.72)	GVRVA.NTSEVDS
  911-  923 (16.35/10.30)	GVLLTyNTVEADS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03161 with Med14 domain of Kingdom Viridiplantae
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