<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03051

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWKSIGELNSEDYVKAGLSLEKAKGFQKVVTDVISRTKGVDPRDQWKALVDECVLKPWHPHPLHQLLYYSIYSNWDASIHGPPLYWFPSLSLSKYTNLGRLMETHGPRLLGASYKNPLESFELFRRFSVEHPEVYWSIVIDELSLKFHTPPRCILDKSKPGGTWLPDAVLNTAECCLIPSSRSQREDDSLAVVWREEGFDDSPVNRMTFKELRQRVMLVANAISGSFATGDTIAIDMTMTVDAVIIYLAIILAGCIVVSIADSFAAKEIATRLKISNAKGIFTQDYILRGGRRFPLYSRVVEAAPSKIIVLPASGTELRVQLRDQDIPWKDFLSKASVENNYGPIYLPVNSVINILFSSGTTGEPKAIPWTQLSPIRSACDGWAHFDVKVGNTYCWPTNLGWVMGPTLIFSCFLTGTTLALYHGSPLGHGFGKFDAGVTILGTVPSLVKTWKRTNCMEGLNWTKIKYFATTGEASNVDDVLWLSSKAYYKPVIEVCGGTELASSYIIGSPLQPQAFGAFSTPTMATRIIIFDENGVPYPDDQPCTGEVGLFPQHFGATDRLLNADHEEVYFKGMPMYKETRLRRHGDILKRTVGGYFTVQGRSDDTMNLGGIKTSSIEIERVCDQADECISETAAVSITPANGGPELLALFAVLKEGFKKLSEEELKRKFSRAIQKDLNPLFKVSFVKIVAEFPRTASNKLLRRVLRDKMNQEIQSGGLHHVSWFQFLPSEAELNPTSDTRDFSSRAEQNDVATYLVLSSHLRLQKEGFLTTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGRHSSITDKAQAAVSKLRVVASGIWVAPGDSEEISVAFSQSLRNCIERALSGLSYMRFGDVFSKVSPQNEEYLRRGRLTVEFIFAATEEAVFVHVIVSAKNVRTLSSGDAERLSRSSLKNSSYRLPDSYTSHRLMLFPPVIVSPHGMRGSLTGFCLNDLVKQVYFSSGNLRSSSGYIGLPPHVDIASRLINGDHCYVEVTLGCCQNINDNTSQTNSTFAVNVPQTSVGSKDHRKGHPDILSKCEKRFIYPAEAVLVPILQSAFAKFSLKRFWLQNWIGPSLAGSSLFMHWAGDFDFFGASGNKSDGFYEKNGYNSSGSSGNSSISSTSSASSGSGWRMTSRTGDLDADADSLTCKDDHPKLGSKRPRTGMAESFGQVGTANDQFGWDWDDDDDDDRGVGMDIQALLSEFGDFGDFFENDALPFGEPPGTAESHSLILPSDSADVGSSPMDMMDVSDQIVLPVGFSSFESFNPAPPIIDEGLIKSQEVINNSVTSASAPSNQMSSSSNSEFDHLMKAEAMMTFAPEYGAVEAPMSELSSTSFKSPYLPKSHKVESSNSRTSNYVYGPTPPATDSNGAADKILLGSKAYIGNNDGRTLYTKVEGRKDQYDKLPTLISDNNSKKKGVFQLKYSNYNAASAVKTVQGKKTDGISAVVSTLLSSKTLLATDVGSVMFQAFMYRMRHKAISSKHSSPVSLSGLSGNFFLNQVPNGPSSLTDNVSARNEIYKKEVPTRIAGDFDGGMLDSHMSAPVGVWRTVSVPKTAKPASSPNIEAGSSLPHSSFSENSLLSYGQKQPLQELLDGIALLVQQATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSAGHAGCGGTLASCHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQSDGPLYVTDWCKGRNQSMDGVSISEGSTAESVLSEVSNAIDGGKGEESAQSQDIYSSELLRPTLFVLPSPSILVGYQDDWLKVSTNSLPHWEKAPFEPYALPKNMNYTVVCPDIDPLTSAAVDFFQQLGTVYETCRLGTHLPTILGNQMETDAGRLSSSGFVLLDCPQSMKIESNNTSLLGSLSDYFLSLSNGWNVNSYLKSLSKALKGLKLGSGLYTNQKEGSASPCMVVYIVCPFPDPSAVLRTVVESSIALGSGIQPDRDRRSLLNSQVARAFGSSAAVDEASISHIPVLSGFSVPKLVLQVVSVDSIFRITSPSFNELVILKDTAFSVYNKARRISRGMPNDAFLSSSSLSSRSSSALASVNSISGIWKDCVSSRMTGSTHPRDGDIDGSIRTSSWDSSWQITRSGGLSCDSNRNGDFYINDAIFYLFEPLFILSEPGSVDRGVSPTFGGLGSESSKPIPEDGGRGSGLGVNSMEGTSSHGDASQVEGKAVPSLHCCYGWTEDWRWLVSIWTDARGELLDTHIFPFGGISSRQDTKGLQCLFVQVLQQGCQILQACSSPENGSFKPRDFVITRIGSFFELEYLEWQKAIYTAGGPEIKKWPIQLRRSAPSGVATNSNGPSLQQHDLSLIQERASSTSTLYGAHSKPSTFVKGGMGHSGGRKQTMGGQTISGTPRGLFQWVHSISFASISLDHSLHFVLPAELVSPGGGQSSTGMSSANYIEGFTPVKSLGSTAFAYMMIPSPNMRFLHPSPLQLPTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPSMRKDSRINVKEEWPSVLSVSLIDYYGGYDNAHDKVLQGIMKQGGGRTKETRDFEVESHLILESIAAELHALSWMTVSPAYLDRRTALPSHCDVVLRLSRLLHFADKERSRLPDKSGV
Length2609
PositionKinase
OrganismBrassica oleracea var. oleracea
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.09
Grand average of hydropathy-0.208
Instability index43.88
Isoelectric point6.03
Molecular weight284383.86
Publications
PubMed=24916971

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP03051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     254.89|      62|     441|    1702|    1778|       1
---------------------------------------------------------------------------
  461-  522 (80.71/38.64)	NWTKIKYFATTG....EASNVDDVLWLSSKAyykpvIEV...CGGTELASSYIIGSP..LQPQAFgAFSTP.
 1707- 1769 (102.88/83.17)	DWCKGRNQSMDGvSISEGSTAESVLSEVSNA.....IDG...GKGEESAQSQDIYSSELLRPTLF.VLPSPS
 1887- 1939 (71.31/32.12)	.............SLSNGWNVNSYLKSLSKA.....LKGlklGSGLYTNQKEGSASPCMVVYIVC.PFPDPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.47|      21|     441|     546|     566|       2
---------------------------------------------------------------------------
  546-  566 (40.21/22.52)	GEV......GLFPQHFGATDRLLNADH
  586-  608 (18.67/ 6.32)	GDIlkrtvgGYFTVQ.GRSDDTMN...
  976-  995 (37.58/20.55)	GYI......GL.PPHVDIASRLINGDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.23|      93|     192|    2069|    2179|       3
---------------------------------------------------------------------------
 2069- 2179 (150.41/100.71)	IWKDCvSSRMTGSTHPRDGDID..GSIRTSSWdSSW.................QITRSGGLSCDSNRNGdfyindaifylfeP......LFILSEPGSvdrGVSPTFGGLGSESS...KPIPEDGGRGSGLGVNSMEGT
 2254- 2374 (137.82/64.49)	ILQAC.SSPENGSFKPRDFVITriGSFFELEY.LEWqkaiytaggpeikkwpiQLRRSAPSGVATNSNG.............PslqqhdLSLIQERAS...STSTLYGAHSKPSTfvkGGMGHSGGRKQTMGGQTISGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.87|      40|      42|    1375|    1416|       7
---------------------------------------------------------------------------
 1375- 1416 (59.17/42.82)	NGAADKILLGSKaYIGNNDGRTLYTkVEGRK.DQYDK.LPTLIS
 1418- 1459 (54.70/31.23)	NNSKKKGVFQLK.YSNYNAASAVKT.VQGKKtDGISAvVSTLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      35|      39|     660|     694|       8
---------------------------------------------------------------------------
  660-  694 (57.21/34.68)	KLSEEELKRKFSRAIQK.DLNPLFKVSFVKIVAEF.P
  700-  736 (52.75/31.37)	KLLRRVLRDKMNQEIQSgGLHHVSWFQFLPSEAELnP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.10|      16|     162|     883|     900|       9
---------------------------------------------------------------------------
  883-  900 (23.67/21.63)	FIFAAteEAVFVHVIVSA
 1048- 1063 (29.42/19.46)	FIYPA..EAVLVPILQSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.03|      83|    1244|     366|     450|      10
---------------------------------------------------------------------------
  366-  450 (146.12/91.32)	KAIPWTQLSpIRSAC.D...GW.AHFDVKVGNTYCWPTNLGWVMGPTLIfSCF...LTGTTLALYHGSPLGHGFGKFDAGVTILGTVPSLVKT
 1608- 1690 (112.52/61.87)	QATSFVDLA.LDSDCgDgpyGWlALEELWRRELSCGPSAGHAGCGGTLA.SCHsldIAGVKLV....DPLSAEV..FPSSVITL..LQSDIKT
 1833- 1869 (37.39/14.68)	...................................................CR...L.GTHLPTILGNQMETDAGRLSSSGFVLLDCPQSMK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.62|      37|     159|    1334|    1370|      11
---------------------------------------------------------------------------
 1267- 1299 (39.98/19.80)	....SFESF.NPAPPiIDEGLIKSQEVINNSVTSASAP
 1300- 1327 (37.61/18.16)	SNQMSSSS.NSEF.D.HLMKAEAMMTFAPEY.......
 1334- 1370 (64.03/36.49)	MSELSSTSFKSPYLP.KSHKVESSNSRTSNYVYGPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.14|      46|     196|    1781|    1832|      12
---------------------------------------------------------------------------
   55-  103 (83.80/44.68)	LKPWHPHPLHQllyYSIYSNWDASIHGPPLYWFPSLSLSKYTNLGRLME
 1786- 1831 (84.35/46.48)	LPHWEKAPFEP...YALPKNMNYTVVCPDIDPLTSAAVDFFQQLGTVYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.94|      31|      38|     223|     254|      15
---------------------------------------------------------------------------
  223-  254 (46.82/37.61)	ISGSFATGDtIAIDMTMTVDAVIIYLAIILAG
  260-  290 (51.13/36.07)	IADSFAAKE.IATRLKISNAKGIFTQDYILRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.65|      57|    1245|     760|     824|      17
---------------------------------------------------------------------------
  760-  824 (85.52/80.01)	SHLRLQKEGFlttwtNSFVGPWDPSQGLYNPDEKIKLWL....FLPGrhSSITDKAQAAVSKLRVVaSG
 2008- 2068 (87.13/57.27)	SIFRITSPSF.....NELVILKDTAFSVYNKARRISRGMpndaFLSS..SSLSSRSSSALASVNSI.SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.35|      30|      78|     830|     862|      18
---------------------------------------------------------------------------
  830-  862 (47.86/39.40)	GDSEEISvafSQSLRNCIER...ALSGLSYMRFGDV
  909-  941 (48.49/31.18)	GDAERLS...RSSLKNSSYRlpdSYTSHRLMLFPPV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03051 with Med13 domain of Kingdom Viridiplantae
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