<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03051

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWKSIGELNSEDYVKAGLSLEKAKGFQKVVTDVISRTKGVDPRDQWKALVDECVLKPWHPHPLHQLLYYSIYSNWDASIHGPPLYWFPSLSLSKYTNLGRLMETHGPRLLGASYKNPLESFELFRRFSVEHPEVYWSIVIDELSLKFHTPPRCILDKSKPGGTWLPDAVLNTAECCLIPSSRSQREDDSLAVVWREEGFDDSPVNRMTFKELRQRVMLVANAISGSFATGDTIAIDMTMTVDAVIIYLAIILAGCIVVSIADSFAAKEIATRLKISNAKGIFTQDYILRGGRRFPLYSRVVEAAPSKIIVLPASGTELRVQLRDQDIPWKDFLSKASVENNYGPIYLPVNSVINILFSSGTTGEPKAIPWTQLSPIRSACDGWAHFDVKVGNTYCWPTNLGWVMGPTLIFSCFLTGTTLALYHGSPLGHGFGKFDAGVTILGTVPSLVKTWKRTNCMEGLNWTKIKYFATTGEASNVDDVLWLSSKAYYKPVIEVCGGTELASSYIIGSPLQPQAFGAFSTPTMATRIIIFDENGVPYPDDQPCTGEVGLFPQHFGATDRLLNADHEEVYFKGMPMYKETRLRRHGDILKRTVGGYFTVQGRSDDTMNLGGIKTSSIEIERVCDQADECISETAAVSITPANGGPELLALFAVLKEGFKKLSEEELKRKFSRAIQKDLNPLFKVSFVKIVAEFPRTASNKLLRRVLRDKMNQEIQSGGLHHVSWFQFLPSEAELNPTSDTRDFSSRAEQNDVATYLVLSSHLRLQKEGFLTTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGRHSSITDKAQAAVSKLRVVASGIWVAPGDSEEISVAFSQSLRNCIERALSGLSYMRFGDVFSKVSPQNEEYLRRGRLTVEFIFAATEEAVFVHVIVSAKNVRTLSSGDAERLSRSSLKNSSYRLPDSYTSHRLMLFPPVIVSPHGMRGSLTGFCLNDLVKQVYFSSGNLRSSSGYIGLPPHVDIASRLINGDHCYVEVTLGCCQNINDNTSQTNSTFAVNVPQTSVGSKDHRKGHPDILSKCEKRFIYPAEAVLVPILQSAFAKFSLKRFWLQNWIGPSLAGSSLFMHWAGDFDFFGASGNKSDGFYEKNGYNSSGSSGNSSISSTSSASSGSGWRMTSRTGDLDADADSLTCKDDHPKLGSKRPRTGMAESFGQVGTANDQFGWDWDDDDDDDRGVGMDIQALLSEFGDFGDFFENDALPFGEPPGTAESHSLILPSDSADVGSSPMDMMDVSDQIVLPVGFSSFESFNPAPPIIDEGLIKSQEVINNSVTSASAPSNQMSSSSNSEFDHLMKAEAMMTFAPEYGAVEAPMSELSSTSFKSPYLPKSHKVESSNSRTSNYVYGPTPPATDSNGAADKILLGSKAYIGNNDGRTLYTKVEGRKDQYDKLPTLISDNNSKKKGVFQLKYSNYNAASAVKTVQGKKTDGISAVVSTLLSSKTLLATDVGSVMFQAFMYRMRHKAISSKHSSPVSLSGLSGNFFLNQVPNGPSSLTDNVSARNEIYKKEVPTRIAGDFDGGMLDSHMSAPVGVWRTVSVPKTAKPASSPNIEAGSSLPHSSFSENSLLSYGQKQPLQELLDGIALLVQQATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSAGHAGCGGTLASCHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQSDGPLYVTDWCKGRNQSMDGVSISEGSTAESVLSEVSNAIDGGKGEESAQSQDIYSSELLRPTLFVLPSPSILVGYQDDWLKVSTNSLPHWEKAPFEPYALPKNMNYTVVCPDIDPLTSAAVDFFQQLGTVYETCRLGTHLPTILGNQMETDAGRLSSSGFVLLDCPQSMKIESNNTSLLGSLSDYFLSLSNGWNVNSYLKSLSKALKGLKLGSGLYTNQKEGSASPCMVVYIVCPFPDPSAVLRTVVESSIALGSGIQPDRDRRSLLNSQVARAFGSSAAVDEASISHIPVLSGFSVPKLVLQVVSVDSIFRITSPSFNELVILKDTAFSVYNKARRISRGMPNDAFLSSSSLSSRSSSALASVNSISGIWKDCVSSRMTGSTHPRDGDIDGSIRTSSWDSSWQITRSGGLSCDSNRNGDFYINDAIFYLFEPLFILSEPGSVDRGVSPTFGGLGSESSKPIPEDGGRGSGLGVNSMEGTSSHGDASQVEGKAVPSLHCCYGWTEDWRWLVSIWTDARGELLDTHIFPFGGISSRQDTKGLQCLFVQVLQQGCQILQACSSPENGSFKPRDFVITRIGSFFELEYLEWQKAIYTAGGPEIKKWPIQLRRSAPSGVATNSNGPSLQQHDLSLIQERASSTSTLYGAHSKPSTFVKGGMGHSGGRKQTMGGQTISGTPRGLFQWVHSISFASISLDHSLHFVLPAELVSPGGGQSSTGMSSANYIEGFTPVKSLGSTAFAYMMIPSPNMRFLHPSPLQLPTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPSMRKDSRINVKEEWPSVLSVSLIDYYGGYDNAHDKVLQGIMKQGGGRTKETRDFEVESHLILESIAAELHALSWMTVSPAYLDRRTALPSHCDVVLRLSRLLHFADKERSRLPDKSGV
Length2609
PositionKinase
OrganismBrassica oleracea var. oleracea
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.09
Grand average of hydropathy-0.208
Instability index43.88
Isoelectric point6.03
Molecular weight284383.86
Publications
PubMed=24916971

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP03051
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     254.89|      62|     441|    1702|    1778|       1
---------------------------------------------------------------------------
  461-  522 (80.71/38.64)	NWTKIKYFATTG....EASNVDDVLWLSSKAyykpvIEV...CGGTELASSYIIGSP..LQPQAFgAFSTP.
 1707- 1769 (102.88/83.17)	DWCKGRNQSMDGvSISEGSTAESVLSEVSNA.....IDG...GKGEESAQSQDIYSSELLRPTLF.VLPSPS
 1887- 1939 (71.31/32.12)	.............SLSNGWNVNSYLKSLSKA.....LKGlklGSGLYTNQKEGSASPCMVVYIVC.PFPDPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.47|      21|     441|     546|     566|       2
---------------------------------------------------------------------------
  546-  566 (40.21/22.52)	GEV......GLFPQHFGATDRLLNADH
  586-  608 (18.67/ 6.32)	GDIlkrtvgGYFTVQ.GRSDDTMN...
  976-  995 (37.58/20.55)	GYI......GL.PPHVDIASRLINGDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.23|      93|     192|    2069|    2179|       3
---------------------------------------------------------------------------
 2069- 2179 (150.41/100.71)	IWKDCvSSRMTGSTHPRDGDID..GSIRTSSWdSSW.................QITRSGGLSCDSNRNGdfyindaifylfeP......LFILSEPGSvdrGVSPTFGGLGSESS...KPIPEDGGRGSGLGVNSMEGT
 2254- 2374 (137.82/64.49)	ILQAC.SSPENGSFKPRDFVITriGSFFELEY.LEWqkaiytaggpeikkwpiQLRRSAPSGVATNSNG.............PslqqhdLSLIQERAS...STSTLYGAHSKPSTfvkGGMGHSGGRKQTMGGQTISGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.87|      40|      42|    1375|    1416|       7
---------------------------------------------------------------------------
 1375- 1416 (59.17/42.82)	NGAADKILLGSKaYIGNNDGRTLYTkVEGRK.DQYDK.LPTLIS
 1418- 1459 (54.70/31.23)	NNSKKKGVFQLK.YSNYNAASAVKT.VQGKKtDGISAvVSTLLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.96|      35|      39|     660|     694|       8
---------------------------------------------------------------------------
  660-  694 (57.21/34.68)	KLSEEELKRKFSRAIQK.DLNPLFKVSFVKIVAEF.P
  700-  736 (52.75/31.37)	KLLRRVLRDKMNQEIQSgGLHHVSWFQFLPSEAELnP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.10|      16|     162|     883|     900|       9
---------------------------------------------------------------------------
  883-  900 (23.67/21.63)	FIFAAteEAVFVHVIVSA
 1048- 1063 (29.42/19.46)	FIYPA..EAVLVPILQSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     296.03|      83|    1244|     366|     450|      10
---------------------------------------------------------------------------
  366-  450 (146.12/91.32)	KAIPWTQLSpIRSAC.D...GW.AHFDVKVGNTYCWPTNLGWVMGPTLIfSCF...LTGTTLALYHGSPLGHGFGKFDAGVTILGTVPSLVKT
 1608- 1690 (112.52/61.87)	QATSFVDLA.LDSDCgDgpyGWlALEELWRRELSCGPSAGHAGCGGTLA.SCHsldIAGVKLV....DPLSAEV..FPSSVITL..LQSDIKT
 1833- 1869 (37.39/14.68)	...................................................CR...L.GTHLPTILGNQMETDAGRLSSSGFVLLDCPQSMK.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.62|      37|     159|    1334|    1370|      11
---------------------------------------------------------------------------
 1267- 1299 (39.98/19.80)	....SFESF.NPAPPiIDEGLIKSQEVINNSVTSASAP
 1300- 1327 (37.61/18.16)	SNQMSSSS.NSEF.D.HLMKAEAMMTFAPEY.......
 1334- 1370 (64.03/36.49)	MSELSSTSFKSPYLP.KSHKVESSNSRTSNYVYGPTPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.14|      46|     196|    1781|    1832|      12
---------------------------------------------------------------------------
   55-  103 (83.80/44.68)	LKPWHPHPLHQllyYSIYSNWDASIHGPPLYWFPSLSLSKYTNLGRLME
 1786- 1831 (84.35/46.48)	LPHWEKAPFEP...YALPKNMNYTVVCPDIDPLTSAAVDFFQQLGTVYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.94|      31|      38|     223|     254|      15
---------------------------------------------------------------------------
  223-  254 (46.82/37.61)	ISGSFATGDtIAIDMTMTVDAVIIYLAIILAG
  260-  290 (51.13/36.07)	IADSFAAKE.IATRLKISNAKGIFTQDYILRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     172.65|      57|    1245|     760|     824|      17
---------------------------------------------------------------------------
  760-  824 (85.52/80.01)	SHLRLQKEGFlttwtNSFVGPWDPSQGLYNPDEKIKLWL....FLPGrhSSITDKAQAAVSKLRVVaSG
 2008- 2068 (87.13/57.27)	SIFRITSPSF.....NELVILKDTAFSVYNKARRISRGMpndaFLSS..SSLSSRSSSALASVNSI.SG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.35|      30|      78|     830|     862|      18
---------------------------------------------------------------------------
  830-  862 (47.86/39.40)	GDSEEISvafSQSLRNCIER...ALSGLSYMRFGDV
  909-  941 (48.49/31.18)	GDAERLS...RSSLKNSSYRlpdSYTSHRLMLFPPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03051 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ADADSLTCKDDHPKLGSKRPRTGMAESFGQ
2) ALPFGEPPGTAESHSLILPSDSADVGSSPMDMM
3) GGLGSESSKPIPEDGGRGSGLGVNSMEGTSSHGDAS
1148
1221
2151
1177
1253
2186










Molecular Recognition Features






MoRF SequenceStartStop




1) GMDIQALLSEFGDFGDFFEND
1200
1220