<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP03047

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRAAEESFLSLTELVEKAKSPELSDTDKKLSLLKYVVKTQQRMLRLNALAKWCKQVPLINSCQDLGSSLSSHDICFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGSYQRLPKCVDDVGMQCSLDEQQQKPALRKLEVLVRSKLLEITLPKEITEVKVSKGTVTLSVEGEFKVLVTLGYRGHLSMWRILLLDLLVGERSGGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRTLLHGRWKDAIRFDLISDTGTAPANQEGEADSVSLKTPGVKLMYWLDYDKNNAGSFVKIEPVSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRSDRICRAPSDVILQAFLDEPGSEGGNMIDSKQQIEPEVLRVRAYGSSFFTLGINIRTGKFLLQSSKSVLTPSILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGVNKAPKSLSDGSSILALGFPDCESSHLLLMELEKDFTPLFKLAETQTDGSGKPQFLNDLSNVLRVKKIDIGQIRILEDDLNLITSDVARFVSSFSDAERSLNQASGHRGPGLVEESLAEMSGGQLSFSSIVDEVFGHQKVTTSADGKAPLLTSYQSDSFYSMQVPLESSSFNLLSSPPPGKGSAMMKNPNKELSMVLSPSLTVVSESADLAVTSDGPLLRKDQKSRKRSASDLLRLIPSLQGVEGVTHPNKKSKTSASQALSTAVVTSTKAIGCSYGDLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDSFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKSTPWGSGVHIANSSDVDSHIRYDPEGVVLTYQSVEADSIKKLVADIQRLSNARRFSLGMRKLLGIKADEKTEEPGGGNAAVKGPAGGKGGGEAVDRWRAFKIEAVGLTSLWFSFGSGILARFVVEWESGKDECTMHVSPDQHWPHTKFLEDFINGGEVESLLDCIRLTAGPLTALAAATRPARASSATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSAVASPSPAPSPLGGSFHGAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGATNPSGSRVNFSPSSAMSRAVMSRVGSVASGSLVVGSGLSVRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQNGSSGTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPIPVLREFLKLIAWKKGLSQSQQAVEVAPAQRPRIELCLENHSGADVETSCAAKSNIHFDRPQSTVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYTFGDNPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSGQRTLHLCLQGLREGSSNNNTLQKEFTI
Length1636
PositionTail
OrganismBrassica oleracea var. oleracea
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.07
Grand average of hydropathy-0.118
Instability index45.87
Isoelectric point6.68
Molecular weight177893.93
Publications
PubMed=24916971

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
plasmodesma	GO:0009506	IEA:EnsemblPlants
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
cold acclimation	GO:0009631	IEA:EnsemblPlants
positive regulation of cell population proliferation	GO:0008284	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
systemic acquired resistance	GO:0009627	IEA:EnsemblPlants

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP03047
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     385.74|      93|     264|    1210|    1310|       1
---------------------------------------------------------------------------
 1093- 1168 (94.06/56.84)	...........................ATS.RQSNQTQQTQP.STL..AAPNAVGQSASGSAVASPspapsplGGSFHGAAGRSGPGIVPSSLLPIDVSVVLRGPY.....W
 1210- 1310 (144.33/118.68)	PQFRPFImehvaqELNgLEpNLTGSQGATN.PSGSRVNFSPS.SAMSRAVMSRVGSVASGSLVVGS.......GLSVRRPPGSGVPAHVRGELNTAIIGLGDDGGYGG..GW
 1475- 1570 (147.36/98.08)	PAQRPRI......ELC.LE.NHSGADVETScAAKSNIHFDRPqSTVDFA.LTVVLDPAHIPHINAA.......GGAAWLPYCVSVRLRYTFGDNPSVTFLGMEGSHGGraCW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.69|     113|     264|     120|     249|       2
---------------------------------------------------------------------------
  120-  249 (158.29/155.55)	EVLLTGSYQRLPkcvDDVGMQCSLDEqqqkPALRKLEVLVRSKLLEitlPkEITEVKV.SKGTVTLSVE...GEF......KVL...VTLGYRGHLSMWRILLLDLLVGERSGGPIKLEVTRRHILGddLErrmsVAENPFTI
  388-  513 (169.40/117.50)	ELLRSDRICRAP...SDVILQAFLDE....PGSEGGNMIDSKQQIE...P.EVLRVRAyGSSFFTLGINirtGKFllqsskSVLtpsILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLG..LE....VYEHGFGV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP03047 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSAVASPSPAPSPLGGSFHGAA
1083
1142










Molecular Recognition Features






MoRF SequenceStartStop




NANANA