<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02956

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLSKVLTRLAQSTHNALQDQIAALAKMPLPAAAMNGNSTVLNSDVEDGSGENIAKKTSILNFAMREHRKWVKALVITEWSRKADMVSKLIDLRFHLQGQEVLFSGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTRQEQIQWISDLDTQLSLRLNLEDFDKIPYHFRNYEIDSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFEPAASSIPDGLKNYLEGQVNDILSKDGLLGCYQFLHELVLTHKLNELKRQAIRLSRGSWTGTLKVEPLNRALAIQYWTSRAQLGSPKSWILIAVNSGRKPNGQPDPKSSSHLMAKWYRDNKEVKDTNISFDADNLSAETLLKTVIGRHVEFLLGSIHSRLQAFPRFQNRDAAMILNISHDDPATSFLSMQVGYKDSASLLVEPTTGVFAVKPHSKFTIQHEHLLNNGKNPADDGATCLENVRCGVMEDELIRRGSTTGWNTKKSPLSKDELRSLTNTREWTKTIWLQRTGWDPNWFVMVMLSPSGDAWWLVDASRNANGQSNRLSSKLPLNKGYPHLEDEFWNNLTLFATGMIAQAVDQHELYRHNIKFLLQDTRNWSLPQQVRLPTLEISLSDIFPSMVFNMAEKDNAKAANEFNAGTETARLGPVAPTASTPGISTRQPWAHDIVSIRFKGVEPVDKEASGAGGPISDVSFMCISDAIIKVRKPTKFAMLKGHMVGRDVSWKARTGEFCLRMRSNIGLSILENLKARVKAVDRFVSFFESLDKARGFIKAESVSLKEVTFSYGPPASQTVEDAEVSRLWRVALNLSNNDIDIQVQETNPHLPVTDLMQKLVNGANGIGALMDWLPASLPTMEAFKKIREAWSDIEARRQGRFKFIMNSTDEMSFQYLLAGTGPGNQQVQRSITFLGQIKQRRGEPWWHIERKIPSSGWPSLNDEFSAALKPVWDGKGDDWSGLVTGATGRPENGIIGLLLAIDEAIRPLAGSTSQNNSEVVILE
Length1019
PositionTail
OrganismFusarium oxysporum f. sp. lycopersici (strain 4287 / CBS 123668 / FGSC 9935 / NRRL 34936) (Fusarium vascular wilt of tomato)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium> Fusarium oxysporum species complex.
Aromaticity0.08
Grand average of hydropathy-0.328
Instability index33.12
Isoelectric point6.55
Molecular weight114094.53
Publications
PubMed=20237561

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.75|      48|     300|     235|     283|       1
---------------------------------------------------------------------------
  235-  283 (81.89/60.72)	WFIDFRFAFEPAASSIPDGLKNyLEGQVNDILSKDGLLGCY.....QFLHELVL
  538-  590 (83.85/56.82)	WFVMVMLSPSGDAWWLVDASRN.ANGQSNRLSSKLPLNKGYphledEFWNNLTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.37|      17|      19|     315|     331|       3
---------------------------------------------------------------------------
  315-  331 (29.42/18.94)	LAIQYWTSRAQLG..SPKS
  333-  351 (22.95/13.00)	ILIAVNSGRKPNGqpDPKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.91|      35|      51|     408|     458|       4
---------------------------------------------------------------------------
  423-  458 (57.27/65.46)	DDPATSFLSMQVGYKDSASLLVEPTTGvFAVK..PHSK
  475-  511 (59.64/32.09)	DDGATCLENVRCGVMEDELIRRGSTTG.WNTKksPLSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.85|      49|     253|     660|     713|       5
---------------------------------------------------------------------------
  660-  713 (84.33/55.82)	AGTetarlGP....VAPTASTPG.ISTR..QPWAHDIVSIRFKGVEPVDKEASGAGGPISD
  914-  969 (80.52/44.31)	AGT.....GPgnqqVQRSITFLGqIKQRrgEPWWHIERKIPSSGWPSLNDEFSAALKPVWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.89|      17|      33|     107|     126|       6
---------------------------------------------------------------------------
  107-  126 (25.53/22.60)	DLRFHLQgqeVLFSGALDVM
  142-  158 (30.37/17.75)	DLKTALQ...VLSTGEAAWM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02956 with Med14 domain of Kingdom Fungi
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