<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02951

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMQSAEASSSAAGASASVSAAAAAAAPMAAVPFRPSVPLSALVEMLLQKAHGELMKLSELLPQFPDKQRKMAIIDYVQRTRGMFVRLLVVVKWASKAAETKSVWELMRFIDSQTACFTVAADALYWTHRNLGHARTPAFALSTAIDVLSTGSYTRMPKAISDIVPPITVNRKDIRRVYQQLNDVVRILLVDSFVPDGFSQVLVNDGRVWLEVPYEFKIALTIDGENEKSLFWRILSIELLVPSPRQKSETRDNPADQFDLISPRQLAGLLELVQGRLFLHRNRKPLQEVYDMLHAFAQSLRLVSLHQQAHRLEVSTWYNHVALAFEPEKSLALTFWKSQRPLAQFEVAHGQGGAAAHRAGGAVQPSAVYLPPLVTEHSLTVLLPSDKTGKLRCRHAPPLIHPRTEEAIHETDLPMYHLNVERLFQVAQFYHKHAKLLAMCHRLRRIQLSEFIYSEDVTEIRESSLEQVDKIDELAPLSALLVRYYSGSYFSLLVDSRTGRYLLREASQQQQQQHSTLLPTRSATSPQANSVGANLFAAVNSKRFQQQIAVLERELNNSQISIGDVLSAMRQIAILARCEHDARRLGFEPLTHLPLSPHDLLATLSKNRLFLKLPHHTHHFVVVDVGEDFSERLHLLRVMQDSAPWMTSDDVSYSSRAGATSGASGSNNSLKPVELVYKAHDIAAVDQAIMEIVTQSAASAQFADIVGRKAASRSQNKRRATDPLQQAVKRERTLLVEQSGAQSSERPILSQQGVSGSWQHATLFARRLFTSRLEFCRVYLPLLTLMDSFQHAGITTRIVNDHNATHAPLVVWVAPALAEDFLAATAARSSTSSSGLPASMTLQSPSLRPVTLSLHLSILVLPSLEPAPSTAFQQRPTSGAGAAGGHPTGVAATGSGVLALGTSALGSAAAAAAAAAAAAGVGASSTPATATRLAASLFSRDHMSLSNLSSCIRSGLISLDAGGDAWRVVMLLHEDASYLLGRGCFELNQSSNVQSGMPCFLQRSSSSSSDGGNECLSFVFPSFSSAGHRFLQEWRAACIMLRLALPLRLLLDTTASGLDSEPNGAANDASTNEEALSAIVRRTGSVLLPNCASKGAPALWAASFFGGFFVVSSFDMRTLVISYGRVVNEVTHSLFASIRFDSQTLRYVVTFGTSGSDGAADNPHSLIAPFLESDLNGHFDLTLLLKNLFITFAPLQALLAHTSAPPSISCIGQLRSTTPLIVLPHAIDSVALVLWGVFSVVLYILPNGFVALHDGADKVPPAQRLTDNGVVPFPQLRAFHARITSRVESVYQASNSTAGQSQNGASRVAELFYRGLPPLSVSDHSPGTPPVAFRGDVLPLVIEALLEDSLPAVSLRQAFILASRDQIVSKSGNLSCPSPFSALTLVTKTQETWSLEHLGNALSLQLASKTGVTEAENQLLRRYLLHYSSKWLRRPHAFVAMLRLAQVPDTVRTQFFKLLSCQLDQDQSKPLRLEICWCVPPSLEWATHLPATGQPVIFVAPAYFRFVVRLIDRKDESSFVDVPITHDVYAGDTRGWEFDSTPVIGRGSAAGQTAPPTNEASTNASPAEAMRVDGSEGAAGGLQMLFSSSSSAHLSTTTTTGASRALLRLMVPENVDLTTDTSQNCPTLFEAVSSLLDKSIAELV
Length1643
PositionTail
OrganismCapsaspora owczarzaki (strain ATCC 30864)
KingdomIchthyosporea
LineageEukaryota> Filasterea> Capsaspora.
Aromaticity0.07
Grand average of hydropathy0.011
Instability index46.09
Isoelectric point7.52
Molecular weight178388.24
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02951
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.75|      63|     246|     491|     556|       2
---------------------------------------------------------------------------
  491-  556 (94.36/66.89)	LLVDSRTGRYLLREASQQQ....QQQHSTLLPTRSATSP.QANSVGANLFAAVNSkrFqQQIAVLERELNN
  733-  800 (94.40/56.39)	LLVEQSGAQSSERPILSQQgvsgSWQHATLFARRLFTSRlEFCRVYLPLLTLMDS..F.QHAGITTRIVND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.42|      41|     246|     818|     864|       3
---------------------------------------------------------------------------
  819-  862 (62.17/36.84)	DFLAATAARSSTSSSGLPASMTLQSPSLRPVTlslHLSILVLPS
  909-  949 (65.25/26.94)	AAAAAAAAAAGVGASSTPATATRLAASLFSRD...HMSLSNLSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     350.27|     117|     396|    1094|    1227|       4
---------------------------------------------------------------------------
 1094- 1227 (170.54/132.45)	GAPALWAA.SFFggFFVVSSFDmRTLVISYGRVvnEVTHSLFA.SIR...FDSQTlryVVTFGT.SGSDGAADNPHSLIA.PFLESDLNGHFDLTLLLKNLFITFAPlqallAHTSappSISCIGQLRSTTPLIVlPHAID
 1492- 1615 (179.73/98.31)	GQPVIFVApAYF..RFVVRLID.RKDESSFVDV..PITHDVYAgDTRgweFDSTP...VIGRGSaAGQTAPPTNEASTNAsPAEAMRVDGSEGAAGGLQMLFSSSSS.....AHLS...TTTTTGASRALLRLMV.PENVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.35|      15|      19|     179|     197|       5
---------------------------------------------------------------------------
  179-  197 (18.68/21.54)	Q..LNDvVRILLvdsFVPDGF
  199-  215 (25.67/13.94)	QvlVND.GRVWL...EVPYEF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.14|      48|     839|     596|     646|       6
---------------------------------------------------------------------------
  262-  316 (72.81/47.24)	PRQLagLLELVQGRLFLHRNRKPLQ.EVYDMLHAFAQSLRLVSLHQQAhrlevSTW
  596-  644 (81.33/67.09)	PHDL..LATLSKNRLFLKLPHHTHHfVVVDVGEDFSERLHLLRVMQDS.....APW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     209.05|      66|     839|     399|     477|       7
---------------------------------------------------------------------------
  327-  397 (104.23/77.67)	EKSLALTFWKSQR..PLAQFEVAHGQGGAAAHRAgGAVQPSAVYLPPLVTEHSLTVLLPSDKTGKLrcrhAP.P
  409-  477 (104.82/72.19)	ETDLPMYHLNVERlfQVAQFYHKHAKLLAMCHRL.RRIQLSEFIYSEDVTEIRESSLEQVDKIDEL....APlS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.99|      12|      21|     112|     123|       8
---------------------------------------------------------------------------
  112-  123 (21.06/14.27)	QTACF..TVAADAL
  134-  147 (15.92/ 8.57)	RTPAFalSTAIDVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02951 with Med14 domain of Kingdom Ichthyosporea
Unable to open file!