<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02849

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSSLVSRTAEESFTSLKELVEKSKSSDQSDTEKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYERLPKCIEDVGMQSSLTEDQQKPALKKLDTLVRSKLLEVSLPKEISEVKVADGTALIRVDGEFKVLVTLGYRGHLSLWRILHLELLVGERSGLVKLEQMRRHVLGDDLERRMSTAENPFATLYSVLHELCVALVMDTVIRQVQALRLGRWKDAIRFELISDGGSGGSSQLNQDNDSDSAAQRTPGLKLVYWLDFDKNSGASDTGSCPYIKIEPGPDLQIKCQHSTFVKDPLTGKEASFFLDQSCIDVEKLLLRAISCNRYTRLLEIQKELMKNVHIFRDASDVVLLSQADEPDSEHRKEDAKLDNKEHEGQELLRVRAYGSSYFTLGINIRNGRFLLQSSQNILSSSALLECEETLNQGTMTAVDVFSSLRSKSIIHLFAAIGRFLGLEVYEHGFAAVKVPKNLVNGSSVLIMGFPESESSYFLLMELDKDFKPLFKLLETQPDPSGKGHSFNDLNNVLRIKKIDISQMQMLEDETNLSILDWRKLLPSLPNVGGPDQISEHDVLNLDGSMQVPGGPSSSFSSIVDEVFEIEKGTSATQFPSQKISSFSSSPASHLTSVPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKPSGSASHYDGSLYPSSGLKGSYNSASFGSFSSGTGRSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLPNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETKICHGPSHDASKHDQNPRKRKISNLLSLIPSLQYIEADAGFSKRRKTSDVACTQQPTSQVLKSSEIISKSETYSYGNLIAEANKGNVPSGIYVSALLHVVRHSSLCIKHAKLTSQMEELDIPYVEEVGLRNASSNIWFRLPCSQGDSWQHICLRLGRPGSMYWDVKINDQHFRDLWELQKGSTSTPWGSGIRIANTSHVDSHIRYDPDGVVLSYQSVEADSIKKLVADIRRLSNARTFALGMWKLLGVRADDKPEEGNANSDVKAPAGGKGPTEAVDKLSEHMRRSFRIEAVGLLSLWFCFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFIDGAEVASLLDCIRLTAGPLHALAAATRPARASPAPGVSGPSGVISSVPKQPGYSPLQGLLPSSSTTNVNQAAAAVPAGNSASASASSIGNHSIHGAAMLAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPSTPPRGGSYVGGSLPCPQFRPFIMEHVAQELNGLDSSFTSGQQTVGPANSNNPNLSSGPQLSANGSRVNLPTSAAMSRAANQVAGLNRVGNSLPGSPNLAVVSSGLPIRRPPGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPVVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQQQNNANSQEELTQSEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLALTQSGDIAPAQKPRIELCLENHTGVNVGDASESSSATKSNIYYDRPHNSVDFALTVVLDPALIPHINTAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRLDEWEKCKQRVARTVEVSGSSPADATQGRLRIVADNVQRALICAFKD
Length1808
PositionTail
OrganismGossypium raimondii (New World cotton)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
Aromaticity0.07
Grand average of hydropathy-0.245
Instability index46.18
Isoelectric point7.57
Molecular weight196845.91
Publications
PubMed=23257886

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP02849
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.57|      44|      51|    1121|    1164|       1
---------------------------------------------------------------------------
 1078- 1115 (19.12/ 7.01)	...........DSI..KKLVADIR..RlsNARTFALG...MWKL..LGvraddkpeEG..
 1121- 1164 (78.43/56.17)	VKAPAGGKGPTEAV..DKLSEHMR..R..SFRIEAVGLLSLWFC..FG........SGVL
 1169- 1217 (62.02/42.57)	VEWESGKEGCTMHVspDQLWPHTKflE..DF.IDGAEVASLLDCirLT........AGPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     146.00|      37|      38|     790|     827|       2
---------------------------------------------------------------------------
  716-  776 (21.27/ 6.02)	KP...SGSashydgslypssglkgsynsasfgsfS.SGTGR.STsakkLSA....SKS.EQDLASLRsP........HS
  777-  822 (54.15/32.26)	VD...NGV..................ldedqlrlP.NDTSK.DT....LSA....SRS.SRLLSPPR.PTLpRVIAQNA
  823-  856 (32.97/13.72)	KP...NGP.....................rsssaG.N...........LTAavrfSGS.SPLASPP........VSQAA
  857-  897 (37.61/16.77)	ETkicHGP...........................sHDASKhDQ....NPR....KRKiSNLLSLI..PSL.QYIEADA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.77|      19|      19|     605|     623|       3
---------------------------------------------------------------------------
  605-  623 (35.44/20.40)	LSILDWRKLLPSLPNVGGP
  626-  644 (35.32/20.31)	ISEHDVLNLDGSMQVPGGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.55|      17|      19|    1230|    1247|       4
---------------------------------------------------------------------------
 1230- 1247 (25.98/19.54)	SPAPGVSgPSGVISSVPK
 1252- 1268 (29.58/16.88)	SPLQGLL.PSSSTTNVNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.54|      45|     167|    1276|    1375|       8
---------------------------------------------------------------------------
 1277- 1321 (77.18/105.48)	NSASASASSIGNHSIHGAAMLA.AGRGGPGIVP.......SSLLPIDVSVVLR
 1683- 1735 (70.36/21.03)	ESSSATKSNIYYDRPHNSVDFAlTVVLDPALIPhintaggAAWLPYCVSVRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.85|      50|     167|    1322|    1375|      10
---------------------------------------------------------------------------
 1325- 1375 (92.80/73.34)	WIRIIYRKRFAVDMRCFAGdQVWLQPATPPSTPPRGGSYV....GGSLPCPQFRP
 1495- 1548 (77.05/46.47)	WVPVVALKKVLRGILKYLG.VLWLFAQLPELLKEILGSILkdneGALLNLDQEQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.13|      40|      43|     263|     302|      11
---------------------------------------------------------------------------
  263-  302 (67.84/39.25)	DTVIRQVQALRLGRWKDAIRFELISDGGSGGSSQLNQDND
  304-  343 (72.29/42.34)	DSAAQRTPGLKLVYWLDFDKNSGASDTGSCPYIKIEPGPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.79|      14|     942|     702|     715|      14
---------------------------------------------------------------------------
  702-  715 (25.90/16.34)	WEAGLQVSQHNNVA
 1646- 1659 (24.88/15.38)	WKKGLALTQSGDIA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02849 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLDSSFTSGQQTVGPANSNNPNLSSGPQLSAN
2) GTGRSTSAKKLSASKSEQDLASLRSPHSVDNGVLDEDQLRLPNDTSKDTLSASRSSRLLSPPRPTLPRVIAQNAKPNGPRSSSAGNLTAAVRFSGSSPLASPPVSQAAETKICHGPSHDASKHDQNPRKRKI
3) VPMNLHSVKAGTPSPKWEAGLQVSQHNNVAKPSGSASHYDGSLYPS
1387
749
686
1418
880
731










Molecular Recognition Features






MoRF SequenceStartStop




NANANA