<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02762
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MQQQRLKQQHALMQQVYPNPSLMGSPQIEPISSGNLPPGFDASTCRSVYVANIHPQVTEPFLQEVFLSTGPIEGCKLVKKDKATYGFVDYFDRRSAALAIVTLNGRQLFGQPIKVNWAYASSQREDTSGHHNTFVGDLSPRAQSLLLQMASLASKLFEVSPNRAIWVSAFRVSQPSFLSSQMQSMPPPPLESTPTSTKEVISLFASLQTQLFEAVGQLQEILDLQDAKQKIAREIRFKDGAVLAFANKLKEAEQVLDVLVDDYSSYRKPKRLKLEDNGVKDAAAADGDSCTTTVVSRLNLSDILSYAHRISYTTFAPPEFGAGQAPLRGALPPAPQEEQMRASQLYNFADLDVGLPKTAETKEKTVEAIIEPPPAQPADTNPLANLAALQGLLPPNFTVPAGWKPNMPVELPANLPVPPPGWKPGDPVPLPPLDSLSIPRMEGPNMRPVPPPGLHKQPEPIQVRHVELDILDPDDDSSDYSSDDGSSDDED |
Length | 491 |
Position | Middle |
Organism | Gossypium raimondii (New World cotton) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae>
rosids> malvids> Malvales> Malvaceae> Malvoideae> Gossypium.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.384 |
Instability index | 59.00 |
Isoelectric point | 4.98 |
Molecular weight | 53668.12 |
Publications | PubMed=23257886
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | RNA binding GO:0003723 IEA:UniProtKB-UniRule
transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP02762
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 82.87| 21| 37| 391| 420| 1
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393- 420 (43.55/33.06) LPP..NFTVPAGWKPNMpvelpanLPVPPP
430- 452 (39.32/13.50) LPPldSLSIPRMEGPNM.......RPVPPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 54.68| 17| 37| 332| 352| 2
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332- 352 (27.58/23.38) PPA.PQEEQmrasQLYNFADLD
373- 390 (27.10/13.24) PPAqPADTN....PLANLAALQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 89.52| 30| 46| 87| 117| 3
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87- 117 (49.89/37.65) FV.DYFDR.RSAALAIVTLNGRqLFG.QPIKVNW
134- 166 (39.63/24.53) FVgDLSPRaQSLLLQMASLASK.LFEvSPNRAIW
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