<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02746

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTNQDTQSDMVVDIESSATTNILPANGLHNDLPLEPSIEELERELPVVDDGQIPLGDLLSRVVQSIYAELSELAETMPNMSDSARKRTLADWVVKTKKQVVKLYAVAKWSRDADTIQKCMNITAFFLTQNAQFEETIHALNYSKESLDPARLRNHDLLTSLDVLTTGSYLRLPTCIKKMAIPPTPLTDAEVAKTLFDMEETIRYRVRMSEIIPVEMSRYHIADGRIHFTVPGLFNASLCLRGADKDDGWFFVSVEFLISVGGDLTGLQEFPRIPSGIIKRHITDEADARLAFYLPMPELQPPIPDAPPRPQLPAGVVDAPLVRVYNFLQMMSLSYQLEILWYQAERMRTLGWADYLSIQMSPDRKILKVSYWIRPPVAQVPNRPRLILPLLGGSFTIAIVQTRAPAQTGPGPARSPKQRVIARLQRKAKLADAKPSDEVEGLKFVVKWEPAKGALGIYISQEDATLPVEALQVDADNLDFEQMLRTVIHRHSKAILAGFQNMLRLGPNKAFSAPGVVSLVLDGKTQALQVNLCADEVVIITLDARTGKLNLRDTGDLAAAGRGPKFASFTDTLNSNPTLLIDALFTLRINTILDLAEQKARYLGLQSYRRRNIRKEELPKLGPDCRGMLYIQLANFPTHYLVLVVTVERFKYALITTKVQTESMYNNMTLEDIAWLDFDRIHDAAIVQNDTDRSPPNIQGSPDEPNLTTKRSYGFHLDTQGLRELYSYCSARVAFINVERQFKIRGIPFTHVNPTSNSPATLELSQIQSSLARSVPALCVQSEHILSGRPAAEAAMPNIRVIPLNWWSKEKAQVVTCVKLKYVQQPMGKTASGSSTIIRPSKRIIYDTTEAVVSFLSEDVNTCVSEFLEEWGRVSTMVVIAREVAQMSKQKKWKDMRLLFFDLQTVEFAYAEDYTVSISCEGDKGGKFDLEFSRTPPQGAMETDDLDSFNPHEDAEPFLCAVLQHAHGGLSPSLHLLVALLRDTLPIVVELEAIRKEGRQHGRSFDIFAKAAGWYRLLYGDFKYALDFRLMNEQRVAILDASHSLYDVHTPGTGKPASAMDPAVEALVLQPIPRMREIAESAVQSGLAAGALVAGKVAAIDVGVICNASGVGPLTRSIHRQIVEHLQQR
Length1129
PositionTail
OrganismHypholoma sublateritium FD-334 SS-4
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Hypholoma.
Aromaticity0.07
Grand average of hydropathy-0.144
Instability index46.59
Isoelectric point6.18
Molecular weight125876.23
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02746
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.50|      46|     197|     442|     514|       1
---------------------------------------------------------------------------
  442-  495 (67.98/80.28)	LKFVVKWEPAKGALGIYISQEDATLPVEALQvDADNLDFEQMlrtvihrHSKAI
  641-  686 (78.51/38.06)	LVLVVTVERFKYALITTKVQTESMYNNMTLE.DIAWLDFDRI.......HDAAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.93|      19|     695|     409|     427|       4
---------------------------------------------------------------------------
  409-  427 (34.51/23.03)	GPGP.ARSPKQRVIARLQRK
 1110- 1129 (30.42/19.37)	GVGPlTRSIHRQIVEHLQQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.34|      30|     695|     241|     275|       5
---------------------------------------------------------------------------
  241-  275 (49.56/55.27)	RGA.DKDDGWFFVSVE....FLISV.GGDLTGLQefpriPS
  938-  973 (41.78/31.67)	QGAmETDDLDSFNPHEdaepFLCAVlQHAHGGLS.....PS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.01|      18|     185|     562|     579|       8
---------------------------------------------------------------------------
  562-  579 (33.54/20.21)	RGPKFASFTDTLNSNPTL
  745-  762 (34.46/20.96)	RGIPFTHVNPTSNSPATL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.38|      17|     561|     506|     522|      13
---------------------------------------------------------------------------
  506-  522 (31.06/20.47)	GPNKAFSA..PGVVSLVLD
 1052- 1070 (25.33/15.19)	GTGKPASAmdPAVEALVLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02746 with Med14 domain of Kingdom Fungi
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