<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02745

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSAHRPTQLADTLLAASLDLPALPAVAYVRFFPASSDAVELARKTILARNPSASSLLDLILPSVHTGPEPFLYAFKISTENDVHAHSQLLASLPLESLSVAECSSFTPPPSTSLLPNPDKRSALSYFYDAVRSRVIDDIVTSAACAVKRQVKRFRNGFLMSQIAPSSDWQYKAITRPLVFCQLQIHFSYTPDGIPSQLLIHPMLIPTPFLDIARSLPLPSGTPITLLPYGTPAYYLTSYTGPTTGLIKQFQSSLQGLGAGQWENTPSLSAEYPSPHSDAPQSSTQSPTFIIGWIKVENKQGEDKGIIIIYPTELCLSYTPHSSSRTSLDYIPELPAPLQPSPQVAPALPSLSDISQGNLDTPLIAPRAQRPAILTSPTSESLHSFRALTLSKTSDLRLVASEVGGYVDAVVRERERERERLKRERENGVSTSPRLVRANATTPAAMTTPTPSSLEASSSGGSTQHMGALTSSNIGGQAASLQTNPNSNTLAGPSTLASRSLPPQPPPPITLSVSMQNYYPSPPQGTPHTVAAPTSPAVDDPSSSTHGNALASSISGPHSAFPSGDMPSIPPETMSMPAVNRPMPAIASASAHPAAPSGATYDLYGMDSAGETYLSMDMDMDMDFGMGDLGLSFGMNVGGMGMDMGDMGSMGMSDIDMGALSVAPSGGGGGAASRGAVGLEFEDAFTDDDFSFFDRPPRAPLPSAPVSHFGGSTGAGIGSLMSPPATHFLHDTGMAQNAQHMWTPGAGDGATPLHHHAYEHEHLPGHGATDGMSSVPATPGVHLSPRAVTLVHGLPTPHDGGASRFDPIPFAASHRRADGKYAHGKFALALGVGLPSPPAEDDDARDQVPHAPASPGHARYTYRSAAAPDSSPGSGGWRLRYDAVTDPRIGVVRKLIGVKRKPGQHGTRDPQRTVPWAGSAAHEDWATPPPPSTTADGDVSEAESEEEEDADEDEDGPDTPLRSRPATPPPAYLPLGPALLPMHFAHAALLALSVPLRPPGSAILPPTLPGPGALPSVPTPVSPAATMGAASERGRSLEGAAQAVGEEVVANPVWAATWRAASVGARSGGAVWASDARTAVALLSRVPGVRAGLGLPEVFGLDSSTEDGAVLQPLTAPMISIGKGDAVIQVLPTAIRFWEKLGLDPIGGRKDVSAFVLFEDEGGQTQALVDTWVTNLRSTYQGKHFGTMSLGTSTFCAKDGFVPLKFDATFRKSFASFIASMTSQANIMLFFVLPITVMSLSSAILRQILSVVKKVAANYRTGQLIFQFIPEQHLFSSLEKPAGYESALDQLAFSVYDRVLVVVDRLRTQRANLSFGDDTRRYFAAPSFTLARPLHTRVSYARAAHASLDVLDRHTLLHVGYHLTACGKWIIATCVDQRGEAYETGVWLAQPPEGEEEGGTLEEYTVRRVWEFAMQFAKKTNVEWRVIFARLGVMSERELQAWTEYLTVHVAASHEQPPLHHTLVCVVPDAAWSFIPSKSSTTATLLLDHSRAGSQVRSVSASKQTPVYTDVSAMTYVIFPTHRIPISIPPSQSDLSLSLSLVPEPTSPAFSSPYSPQPYPHPSVPDTLYPPVQRVHTPAASSSANLVPSPAVPPHPITILPPYTALLIRVPHAASTSVVCTTAVHLLRTFHSAAQPHALAPPDDRTLLDEVSRNYYELAVLAAVRMRLDGVGGHRGLPLHLAAVDAMRMALDREWDRLEAVVEI
Length1704
PositionKinase
OrganismHypholoma sublateritium FD-334 SS-4
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Strophariaceae> Hypholoma.
Aromaticity0.07
Grand average of hydropathy-0.140
Instability index49.48
Isoelectric point5.89
Molecular weight181378.87
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02745
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     276.70|      39|      39|     514|     552|       1
---------------------------------------------------------------------------
  237-  279 (35.47/ 7.80)	TSYTGPTTGLIKqfqsSLQGLGAGQ..WENT.....PSLSAEYPSP...HSDA
  506-  540 (61.24/18.56)	PPPIT....LSV....SMQNYYPSP..PQGT.....PHTVAAPTSP...AVDD
  541-  581 (48.18/13.10)	PSSSTHGNALAS....SISGPHSAF..PSGDmpsipPETMSMP......AVNR
  981- 1015 (44.57/11.60)	PMHFAHAALLAL....SV....PLR..P.PG......SAILPPTLPgpgAL.P
 1543- 1570 (48.86/13.39)	PEP..TSPAF.S....S.....PYS..PQPY.....PHPSVPDT......LYP
 1571- 1602 (38.37/ 9.01)	PVQRVHTPAASS....SA.NLVPSPavP.PH.....PITILPP..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.77|      36|      39|     638|     675|       2
---------------------------------------------------------------------------
  638-  673 (68.16/29.21)	GGMGMDMGDMGSMGMSDIDMG........ALSVAPSGGGGGAAS
  682-  714 (27.14/10.76)	.......ED....AFTDDDFSffdrppraPLPSAPVSHFGGSTG
  715-  750 (47.46/17.17)	AGIGSLMSPPATHFLHDTGMA......qnAQHMWTPGAGDGA..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     190.79|      38|      39|     774|     811|       3
---------------------------------------------------------------------------
  774-  811 (68.48/27.31)	SVPATPGVH..LSPR.AVTLVHGLPTP..HDGGAS.RFDPIPFA
  813-  850 (43.92/15.02)	SHRRADGKY..AHGKfALALGVGLPSPpaEDDDA..R.DQVPH.
  851-  884 (34.40/10.26)	.APASPG.HarYTYR.SAAAPDS..SP..GSGGWRlRYDAV...
  886-  917 (43.99/15.06)	....DPRIG..VVRK.LIG.VKRKPGQ..H.GTRD.PQRTVPWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.14|      16|     818|     108|     125|       4
---------------------------------------------------------------------------
  108-  125 (27.47/18.91)	PPPSTSllPNPDKRSALS
  929-  944 (30.67/15.21)	PPPSTT..ADGDVSEAES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.25|      20|      28|    1023|    1050|       5
---------------------------------------------------------------------------
 1023- 1043 (32.56/31.41)	P..AATMGAASERGRSlEGAAQA
 1052- 1073 (34.69/13.81)	PvwAATWRAASVGARS.GGAVWA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.29|      21|     523|     417|     454|       6
---------------------------------------------------------------------------
  362-  382 (38.05/25.61)	P.LIAPRAQRPAILTSPTSESL
  433-  454 (34.25/12.94)	PrLVRANATTPAAMTTPTPSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.00|      14|     956|      21|      34|       8
---------------------------------------------------------------------------
   21-   34 (27.45/11.00)	PALPAVAYVRFFPA
  965-  978 (29.55/12.43)	PATPPPAYLPLGPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.02|      17|     956|     188|     204|       9
---------------------------------------------------------------------------
  188-  204 (33.33/14.31)	SYTPDGIPSQLLIHPML
 1103- 1119 (30.70/12.65)	SSTEDGAVLQPLTAPMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.08|      23|      28|    1162|    1185|      15
---------------------------------------------------------------------------
 1162- 1185 (37.46/34.03)	GGQTQALVDTWV.TNLRSTYQgKHF
 1191- 1214 (36.62/26.84)	GTSTFCAKDGFVpLKFDATFR.KSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.16|      23|     268|      47|      70|      16
---------------------------------------------------------------------------
   47-   70 (38.22/23.19)	LARNPSASS..LLDLI..LPSvHTGPEP
  316-  342 (34.94/16.65)	LSYTPHSSSrtSLDYIpeLPA.PLQPSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02745 with Med13 domain of Kingdom Fungi
Unable to open file!