<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02743

Description Uncharacterized protein
SequenceMTSISPAEPRPPLLRRPTDSKRPPVGRASSHVFSPIDRKVPALQRETVEAGGDRPTKRRKIEANPNSNRIVNNRNPSLPAKVSDSNVDAKVVHWRWVNPSAIRAAAANSQSEEEEENSSEDDVPELPPRPWRTTRAAKVTDKPTPTHRSRVDIPVPNAPDSIQIPSSAPQFVPKKPVGFFPWTGKHPEDVLNDNNVKNGYFDKPPNPTEKELNTARFSLYNVFKHKSGVDSLSTLFSLVLNQKSQHGLISSASTFKPPPRVTLTEAKRKSWIADLANADVPLRRLSRTIPQGIKGQTLLDQCLQSSVPLSRAIWFAKCVCANEIRTLKRKGTAPAVAVGAENKWLREWTVNVEQFLETYLGQANSPDWKSNIQYALRLITRLYLENLLDRGHYLEWILRSFTAADVGHAPFWLMVIHIYKQDLSHYRRRGARLARALIDKYRSIDKLPGQTITPLRQKLRAAIRELLFACPAIFLMPDRWPESVPVVRSCLDTTIGLEGQIFEELNRINERVMGFNKAEFLSVRAPDEAIVETLDAARVPYNFALLEQELAGTCSDFDLLLRSCLEWSCTRFRQSKTRVYLVTRLVKRWQRGGRDIDTPILNFLSAFREGKTTADTQRLRHLIAQFSRSNCFPLSKYIQWLMVRGLPQKGTVRIDTDSIFGRTAGVALPKEPGSIQFLLDLSLHRTEDHVVNLRNSVLERAGFDHNSEEAIFGQCVRFLEQKLANSSFITKSEPSTLLEPSFASLPWTLRTRIAMWLRTRALEAAQSAQSTPILPGSKVLNEEQFFVIRHVLECMEDEAVLADVVGILSGSQRDDLVASLVATVHFHASAFSAIGALEVLQKRMCQLYMNWRATKPTMPLLTSTLLDLCTAFPVKAPAVRLLQQDLVRGDRGRAVAACSPYSDGIAESLQQAGATFVEDFEAILQSETNMNEQTMNGLFSVLVDRIEKQQKFEDDAHTVQSFCQLLSRLRLCRKAQGDLLIQKWISRLAPRLDLKSGPLLLRILIATGCITFATLFEATASSKSGPRKNLAVASLLYQVLAPANSTSLDWATYQTRIRWYEYSQRYPSTALEILCEAGLQGVSPSFDSLLLAVLVNGWTSDSSLPDFARKWFIKSLSWTLKCSDGDLNVADLQALLESINVFSHRFVQLRFRLTSPAAVEKVSAPDQPDLVEVLSQSLKQSLQNQPHTHGQEQRFSQLYQIVGSDVASQVRHNIENEFLDALPKLPIGKATSPLSAVFPSDVQQLSSIVEQAFQVCRKDTGPSPGFMSHLIDRLSQHLKYLSNIQITPGTPAASGTSAPSGMSGPSASSTSINHSQMVSMTSSPIASTSDVGGGCVPAVGLSYLRYMLQMVCLQRPTLILSSSNAPNAKQVQNEQLQLLVRLASIATHPAMTLASGHPGNQEEQTKAKEVVDFAFDVMATIIDGVSDEVKMMCAKVLKDKLQDARLSYLFGSINMMGSVQVQDMGRGLQMAKEGKGIIGEWKPRMWEVLDNGSGKESETSLGLGLFRARYV
Length1511
PositionKinase
OrganismFonsecaea multimorphosa CBS 102226
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index50.01
Isoelectric point9.08
Molecular weight168216.66
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02743
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.80|      27|      34|    1291|    1324|       1
---------------------------------------------------------------------------
 1293- 1320 (43.28/41.60)	ASgTSAPSGMSGPSASSTSINHS.QMVSM
 1326- 1353 (45.52/20.12)	AS.TSDVGGGCVPAVGLSYLRYMlQMVCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     132.13|      32|      34|      95|     127|       2
---------------------------------------------------------------------------
   64-   93 (40.00/19.18)	....NPNSNRIVNNRNPSLPAKVSDSNVDAKVVH
   95-  127 (46.88/27.86)	R.WvNPSAIRAAAANSQSEEEEENSSEDDVPELP
  129-  159 (45.24/22.90)	RpW...RTTRAAKVTDKPTPTHRSRVDIPVPNAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.86|      19|      36|     986|    1004|       3
---------------------------------------------------------------------------
  986- 1004 (31.55/17.77)	SRLAPRLDLKSGPLLLRIL
 1022- 1040 (31.30/17.57)	SKSGPRKNLAVASLLYQVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.38|      22|      36|    1196|    1218|       5
---------------------------------------------------------------------------
 1196- 1218 (34.07/25.93)	SQLYQIVGSDVaSQVRHNIENEF
 1232- 1253 (37.31/23.70)	SPLSAVFPSDV.QQLSSIVEQAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     201.51|      54|     209|     846|     926|       6
---------------------------------------------------------------------------
  560-  610 (60.89/29.56)	.........LLRSCLEWSCT...RFRQSKTRVYLVTRLVKRWQRgGRDIDTPilnflSAFREG
  851-  904 (93.94/110.78)	WRATKPTMPLLTSTLLDLCT...AFPVKAPAVRLLQQDLVRGDR.GRAVAAC.....SPYSDG
  928-  968 (46.68/17.54)	TNMNEQTMNGLFSVLVDRIEkqqKFEDDAHTVQSFCQLLSR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.76|      11|      36|     768|     778|       7
---------------------------------------------------------------------------
  768-  778 (20.13/12.06)	AQSTPILPGSK
  802-  812 (18.63/10.56)	ADVVGILSGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.15|      29|      36|     360|     393|       8
---------------------------------------------------------------------------
  360-  393 (35.39/44.69)	LGQANSPDwKSNIQYALrLITRLYLENLldrGHY
  398-  426 (52.76/37.94)	LRSFTAAD.VGHAPFWL.MVIHIYKQDL...SHY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.08|      22|      42|     268|     290|      10
---------------------------------------------------------------------------
  268-  290 (35.31/26.69)	RKSWIADLANADvPLRRLSR..TIP
  311-  334 (36.77/23.00)	RAIWFAKCVCAN.EIRTLKRkgTAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.88|      17|      35|    1355|    1372|      13
---------------------------------------------------------------------------
 1355- 1372 (24.25/15.24)	RPTLILSSSNaPNAKQVQ
 1388- 1404 (31.63/16.30)	HPAMTLASGH.PGNQEEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.60|      18|      35|     445|     463|      14
---------------------------------------------------------------------------
  445-  463 (25.44/16.51)	DKLPgQTITPLRQKLRAAI
  478-  495 (33.16/17.31)	DRWP.ESVPVVRSCLDTTI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02743 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTPAASGTSAPSGMSGPSASSTSINHSQMVS
2) MTSISPAEPRPPLLRRPTDSKRPPVGRASSHVFSPIDRKVPALQRETVEAGGDRPTKRRKIEANPNSNRIVNNRNPSLPAKVSDS
3) NPSAIRAAAANSQSEEEEENSSEDDVPELPPRPWRTTRAAKVTDKPTPTHRSRVDIPVPNAPDSIQIPSSA
1289
1
98
1319
85
168










Molecular Recognition Features






MoRF SequenceStartStop




1) KVVHWRW
2) MTSISPAEPRPPLLRRPTDSKRPPVGRASSHVFSPIDRKVPALQRE
90
1
96
46