<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02739

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAIKTDFGEIAYIVCTVATPPTQDPSAFITTAENTLARLRKTERQFREASILAALDVEARQLFTFYKKVDITAPKDQKTLLLKFGYVLRTNTCTIAYKTAARLPDLLKPEQSRLYRLFITAIVSSIKFVPVGEAELQPLGPNLYLVEQAPSAADVHHLDRAKKWTLYHIDLQVVPSGQIILTIAKDGAFTFFRIRECAMKPNWNDHIKSETAAIYLAPIGRIARSTRSKILASTKLNGITGNQPSGETQLSNAQREVCEELLPSWLQEHMSTTIEAIEGDWIEIEIPVEEIDDVSNDSQPDNSSPDMVRYDSVTWRTIFWPARLCFVFSSEEPVAVNKTEGNQDPMQFVRDWILGTGSGTSKLEAERQNVMDEDDEPLFTDEGTFDDPVHFHPFGPPSFGPGQTIYPTPSEVGMTHLTPGFSSADGMAMTPANIPRGTAERPQPQDEDMPDFEDEPTASGLQTFYDEDLFEENPDDNLGAEANGDEPNWDFFDGPGIDPNSARATSHGRIEETAVRSEIEPGMMGVNDESADQGAASRDPAMVKGEVTGSDTAPKVSANSNLQQSQGRTEQPTTVTEAKSKRASQLPPKRGPPLWRPESAKEPTIGAERERRSSLYDGLHSLPSVSRHDSRYGAGGDYWFDPTPTFSNIKGFSKPNPLLQRPASSSSDSDSLMTSSSNSADPASTQSAAHVPFRQWTEYHPPSPSATNRQSEIDKNTIYQNVQQLLGFLRPGLIEPPTLSDFWLDNSDHRRIPPVSPQKLLQIAHVLVEQVSQTTLLPHGEYQRVTQLPPRDQMDVIVDLSGINTSAAPSSVFQLTNLKAEQSNGRVHGKVMRIQPDQIRIRRMERPLTASMSILNFWDSLNLQPENGPKDVTSFCIHPSQENVTEGCLSLLQRLAETYTSCSLGNHSIGRLPGITDTGSISWGPNDLGQHSLLQTCNFVGTALATSSDVKGTVLVCMIARNQSAISYLESCIAFLYLFESFTEARTDNQGVSDIALQVIPQNFVASAEALVIPPQTAYIQLAIEVYNRLPPSEFPAPPAACSSAVVLSKSENSVHLQLTPTYGSPLEKNGPCLHLAYSVSQDNRWLTAAWTDELGRVALSMSYCLRIRPSGKSRPRHDIFREMWDVSQDLMSKVRGPWRLAVVKHQYYDQPELLDWHQLFENSPTSQKRCLLVLLSVQLDPELEIFLPANQGKSAQTGAQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDPNNESDLILLDPSEESWGVILPFGINQTRSLIDLRPSQVTGYLMKRRGTKWEDGHNLIEFSLVTSTIHISNTSSETSPDELLEDLIKQYRGLVTLGATRGCVDPNSECLPWHIATAIRGAQLLGQAM
Length1372
PositionKinase
OrganismFonsecaea multimorphosa CBS 102226
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.423
Instability index53.97
Isoelectric point4.98
Molecular weight151374.93
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02739
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     124.93|      16|      19|     397|     412|       1
---------------------------------------------------------------------------
  397-  412 (32.33/14.75)	PSFGP...GQT...IYPTPSEV
  419-  434 (27.08/11.23)	PGFSS...ADG...MAMTPANI
 1228- 1240 (20.96/ 7.12)	PG.GS...SFM...NAPTPS..
 1242- 1260 (23.09/ 8.55)	PGFDPnneSDL...ILLDPSEE
 1267- 1284 (21.46/ 7.45)	P.FGI...NQTrslIDLRPSQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     162.94|      55|      66|     517|     581|       2
---------------------------------------------------------------------------
  499-  557 (89.81/65.86)	PNSARATSHGRIEE.TAV.....R..SEIEP..GMMGVNDESADQGA....ASRDPAMVKgevtGSDTAPKVS
  558-  626 (73.14/59.83)	ANSNLQQSQGRTEQpTTVteaksKraSQLPPkrGPPLWRPESAKEPTigaeRERRSSLYD....GLHSLPSVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.70|      51|      73|     641|     695|       3
---------------------------------------------------------------------------
  641-  695 (81.16/63.12)	DPTPTFSN................IKGFSKPNpLLQRPASSSSDSDSlmtSSSNSADPASTQ...SAAHVPFRQ
  701-  770 (79.54/49.02)	PPSPSATNrqseidkntiyqnvqqLLGFLRPG.LIEPPTLSDFWLDN...SDHRRIPPVSPQkllQIAHVLVEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.95|      31|      68|    1091|    1121|       4
---------------------------------------------------------------------------
 1091- 1121 (56.51/34.44)	WTDELGRVALSMSYCLRIRPSGKSRPRHDIF
 1157- 1187 (54.44/32.91)	WHQLFENSPTSQKRCLLVLLSVQLDPELEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     407.20|     131|     563|     216|     363|       5
---------------------------------------------------------------------------
  216-  363 (213.81/133.87)	LAPIGRIARST....RSKILASTKLNGI.TGNQPSGETQLSNAQREvceellPSWLQEHmsTTIEAIEGDWIEI...EIPVEEIDDVSN..DS...QPDNSSPDMVRY......DSVTWRTIFWPARLCFVFSSeepvavnKTEGNQDPMQFvrDWILGTGS...GTSKL
  776-  928 (193.38/95.03)	LLPHGEYQRVTqlppRDQMDVIVDLSGInTSAAPSSVFQLTNLKAE......QSNGRVH..GKVMRIQPDQIRIrrmERPLTASMSILNfwDSlnlQPENGPKDVTSFcihpsqENVTEGCLSLLQRLAETYTS.......CSLGNHSIGRL..PGITDTGSiswGPNDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.95|      19|      71|     365|     384|       6
---------------------------------------------------------------------------
  365-  384 (31.91/21.12)	AERQNVMDEDdEPLFTDEGT
  439-  457 (39.04/21.66)	AERPQPQDED.MPDFEDEPT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02739 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GTSKLEAERQNVMDEDDEPLFTDEGTFDDPVHFHPFGPPSFGPGQTIYPTPSEVGMTHLTPGFSSADGMAMTPANIPRGTAERPQPQDEDMPDFEDEPTASGLQTFYDEDLFEENPDDNLGAEANGDEPNWDFFDGPGIDPNSARATSHGRIEETAVRSEIEPGMMGVNDESADQGAASRDPAMVKGEVTGSDTAPKVSANSNLQQSQGRTEQPTTVTEAKSKRASQLPPKRGPPLWRPESAKEPTIGAERERRSSLYDGLHSLPSVSRH
2) KGFSKPNPLLQRPASSSSDSDSLMTSSSNSADPASTQSAAHVPFRQWTEYHPPSPSATNRQSEIDKN
3) QTGAQNLYGTPASTPQGSMTSPEQTVPATPTPGGSSFMNAPTPSDPGFDPNNESDL
359
650
1197
628
716
1252










Molecular Recognition Features






MoRF SequenceStartStop




1) LQTFYDEDLFEE
461
472