<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02737

Description Mediator of RNA polymerase II transcription subunit 10
SequenceMAPYKASDPRRGAGPVARPSNAQMTDPQSPPRPPNFGKDQRARTPQGTGVASGAGTPISRAGRVGRFPNDRTQRVIRHQKTPYVYRIGIRLPKEKLRQFPRYNGTVRRFLYGSAGSFVTLKVPRLHTILISRRGQFPSTRGIGQIDTAVTAVPEAPFSPSSATALSGAPSIFSEVEQYSDVRTPATNEPSPQENWSNDGLRDEWKGAEQQLLSATGGSNIADGQNTPFPYHNTQLIASGSFDKSFGLSNPSGSDFEDRPVAERVLSNTNDDAMAPVKDTTNVHNTIKDIIQHLTDIQIQTHGYIPATQDLLVDKLTDLTNSLSQLKHLTSPTESPNNYIHQVAIAPEIVDYVDDGRNPDIFTRDFVENVQRGNAVVNGKQQAFREFTEVLAQKLKEGIPGVSKEVDRVLRNAGFDEQHDSTANGDEQMASQHEEANKNGPANG
Length443
PositionMiddle
OrganismFonsecaea multimorphosa CBS 102226
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.07
Grand average of hydropathy-0.722
Instability index35.49
Isoelectric point6.82
Molecular weight48472.03
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364146

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02737
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.02|      31|      33|       9|      41|       1
---------------------------------------------------------------------------
    9-   41 (50.38/27.10)	PR..RGAGpVARPSNAQMTDPQSPPRPPNfGKDQR
   42-   74 (49.64/19.64)	ARtpQGTG.VASGAGTPISRAGRVGRFPN.DRTQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.75|      33|      34|     280|     313|       2
---------------------------------------------------------------------------
  280-  313 (53.05/33.55)	TNVHNTIKDiIQHLTDIQIQTHGYIP..ATQDLLVD
  316-  350 (51.70/28.60)	TDLTNSLSQ.LKHLTSPTESPNNYIHqvAIAPEIVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.36|      19|      34|      98|     129|       3
---------------------------------------------------------------------------
   98-  123 (26.05/36.74)	QFPRYNGTvrrflyGSAGSFVTlKVP
  135-  153 (35.31/14.11)	QFPSTRGI......GQIDTAVT.AVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      11|      33|     212|     222|       4
---------------------------------------------------------------------------
  212-  222 (19.06/10.67)	LSATGGSNIAD
  247-  257 (20.69/12.18)	LSNPSGSDFED
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02737 with Med10 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLSNPSGSDFEDRPVAERVLSNTNDDAMAPVKDTTN
2) MAPYKASDPRRGAGPVARPSNAQMTDPQSPPRPPNFGKDQRARTPQGTGVASGAGTPISRAGRVGRFPNDRTQRVIRHQ
3) VDRVLRNAGFDEQHDSTANGDEQMASQHEEANKNGPANG
246
1
405
281
79
443










Molecular Recognition Features






MoRF SequenceStartStop




1) MAPYKASDPRRGA
2) QHEEA
3) TPYVYRIGIRL
4) VRRFLY
1
431
81
106
13
435
91
111