<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02726

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTSLDFPNNCSTNVYTLNDFSEIAYIVCTVATPPTQDPSAFVSSPENTLARLRRTERQFREASILAALDVEARQLFTFYKKVDIANAKDQKTLLTKFGFVLRSNTCTIAYKTAARLPDLMKPEQSRLYRLFTTAIVSSIKLRPHGDTALQPLGLNLYLCERPTPDSEMPAVESIRRWSLQRIDLQVVPSGHIILTVASDDRLSFTRALDLGQDFDWDQYSKTDSPALYLAPIGRIARIVGPGTNRGVRFGLDTREPRADGCQTADPRKALWKELLPPWLKEHMNTILEYKDVTWLEAEIPVQEVDTESTDSQRFSSSEHVNNDLVTWRTVFWPSNLCFLLDSERSSSKEAFHNGEDPMQFVQDWIAGTAMEPPADTKAHRDTSEDEDEPLFTEDGAFDDSEHFQPFGPPAFPVSQTIYPTPPEGGMTHLTPGLSSLERMAITPANVPRGPSDMAPNQDEEMHDFEELPAASDLPSFYDEDLFEEMPDDNFGPEGAGDEPNWDFFDRPGIDAKSTPKSPSNRGDVPTKRLESVEETHAAEKDLARDEEEEMKSNSQTDGRKENASFDTTMTTQEVARPHQSPHHEEETDVARQAHSDQKPHFPTKPSVPLWKHNNDELKPHKTSSCRRSSVYEIVDMIPNTSSRDSRYTANGDYWFDPNPSISKSTDISNIKTIFRRPPSSSSESGISTGSSGLPPSYGGLGNGAPAPSRQWTEYHPDSPGLISHNGEVERKSIRQEIQYLLTLFKPGLLEYPELSDFDLQEKSSPTPTMSAQKFLLIAHILVDQITQTSLISRPGEQEEPHDLSADHMEVSVDLSGVNTCANPSSLYQLVNFKADHNNAKSQGRIVKFPPNQIRVRRSDQPLVASISILEFWDTLNLQPESGSKNVTAFCVHPHAQNVADGCSNLLKRMTDTYHTCGLGVHMMGQVTGLTENGLISWGPAASSQSNLRQTCQRIGTTIASASDLKGTVLIYMISQDESSTSYLEACSAFHDLYESFTQGLADRQDISDIALQVVPQGFVASAETLVIPPQYAYLKLAIEVYNRLPPPDTAGLPAACGSAIILAKEESSVHFQLSPTFRSPLSNNGPCLHLAYSVSPDDRWITAAWTDECGRVALTMSYCALVRDPGKKRPRQEILEEMWEVSHDLVSKDRGPWRLAVIKRGYYDPAELLEWRQIYHSSTPSQKHCLLMLLSCQVNPLLRVLPQSNLGKTPHPGMQNMYGTPGSTPQASITSPDQLVPATPTPGGSSIMNAPTPPDPGFDPNIECDLTLIDPTEESWVIVLPYGVNQTANMNDLRPALATGLLMKRKGPKSEDGCTSIEISLISSFTQATDSSSETSADDLLEDAIKQYRGLATLGMTRVCSDPHAHCIPWHIATATRGSQILGQVM
Length1387
PositionKinase
OrganismRhinocladiella mackenziei CBS 650.93
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Rhinocladiella.
Aromaticity0.07
Grand average of hydropathy-0.498
Instability index52.99
Isoelectric point4.98
Molecular weight153715.18
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     427.52|     135|     215|    1016|    1162|       1
---------------------------------------------------------------------------
 1016- 1162 (216.13/141.49)	PQGFVASAETLVipPQyAYLKLAIEVYNRLPPPDTAGLPA.ACGSAIILAKEESSV...HFQLSPTfrSPLSNNGPCLH...LAYSVSPDDRwitaawtDECGRVALTM.SYCALVRDPGKKRPRQEILEEMWEVSHDL.......VSKDRG....PWRLAVIKRG
 1226- 1379 (211.39/111.94)	PQASITSPDQLV..PA.TPTPGGSSIMNAPTPPDPGFDPNiECDLTLIDPTEESWVivlPYGVNQT..ANMNDLRPALAtglLMKRKGPKSE.......DGCTSIEISLiSSFTQATDSSSETSADDLLEDAIKQYRGLatlgmtrVCSDPHahciPWHIATATRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.71|      14|      17|     656|     669|       2
---------------------------------------------------------------------------
  656-  669 (25.90/14.78)	FDPNPSISKSTDIS
  675-  688 (25.81/14.70)	FRRPPSSSSESGIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     440.29|     144|     249|     150|     318|       3
---------------------------------------------------------------------------
  150-  318 (223.41/180.71)	LQPLGLNLYLCER...PT.PDSEM....PAVESIRRWSLQRIDlqvVPSGHIILTVASDDRL.SFTR...ALDLGQDFDWDQYskTDSPALYLAPigriariVGPGTNRGVRF....GLDTR.EPRADGCQTADPRKALwkellppwlKEHMNTILEYKDVTWLEAEipvqEVDTES.TDSQRFSSS
  404-  565 (216.89/126.65)	FQPFGPPAFPVSQtiyPTpPEGGMthltPGLSSLERMAITPAN...VPRGPSDMAPNQDEEMhDFEElpaASDLPSFYDEDLF..EEMPDDNFGP.......EGAGDEPNWDFfdrpGIDAKsTPKSPSNRGDVPTKRL.........ESVEETHAAEKDLARDEEE....EMKSNSqTDGRKENAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.21|      21|      24|     703|     723|       4
---------------------------------------------------------------------------
  703-  723 (42.63/27.51)	NG.APAPS.RQWTEYHPD..SPGLI
  726-  750 (23.57/11.47)	NGeVERKSiRQEIQYLLTlfKPGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.43|      17|      17|     579|     595|       5
---------------------------------------------------------------------------
  579-  595 (30.81/20.98)	HQSPHHEEETDVARQAH
  598-  613 (28.14/18.35)	.QKPHFPTKPSVPLWKH
  617-  628 (17.48/ 7.88)	ELKPH...KTSSCRR..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02726 with Med13 domain of Kingdom Fungi
Unable to open file!