<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02721

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMPEPNSISLLIPPEPTSRSQDLQTQIQRITAQRGHFRHVTERSLLAEIQGKASAPDVLDSRREDDAQAEEDEPPQKRRERLWKCREEMLERLSYAQNEILCALDFVSLLISKQSTPAQSSMSPALKEAVPAGTLAARVLPHQTLSTSVKRQLAATSQGWRSESFRSASEKLSAASSRLKNDAERESEYWAQVADLTTHGWAVSRLPRDRKAIGVHFGFTESAPQFGDRGFALLRQSDDGTVTLDQQSTRRRRKRLGVYVIRDQVKTGGYHFQTRGEGPTGDIGQQLTDMRDSLFEEELFYEICREARIVANQGIAARAQAVEIDVGGDYQLALVSAEEQPSDVSSTNPEDNTIAEFVGISLRLLLTAAHEQNLIRRSQKPPPMTLKPRPIPEYALLRPILARLRHKSETTAFWNSCQALIRPLKSASVPVSLEMENSNAGFNSLNIEAPDTVLANLMLPAKTGFKISLTGGRSLAIGLATFLGPPLFGSRYETSSIDFGFSTLPAARQETREAAVSFVRQVLMLDLVSGAESLSRQIRTGQDGKSQQWKVSQPHSGELCLYDSDEAVKKVQIAVQPQSFGVKLCTWGRTSSPENASWSWTSTGASRAQGSEVRTEYGVTFDHVLSLILKAEV
Length632
PositionHead
OrganismRhinocladiella mackenziei CBS 650.93
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Rhinocladiella.
Aromaticity0.06
Grand average of hydropathy-0.440
Instability index56.86
Isoelectric point6.83
Molecular weight69902.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364140

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02721
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.08|      36|      40|     207|     246|       3
---------------------------------------------------------------------------
  207-  246 (52.45/44.78)	RDRKAIGVhFGFTEsapQFGDRGFALLRQSDDGTVTLDQQ
  250-  285 (64.63/40.59)	RRRKRLGV.YVIRD...QVKTGGYHFQTRGEGPTGDIGQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.92|      29|      29|     325|     353|       4
---------------------------------------------------------------------------
  325-  353 (49.34/36.96)	VGGDYQLALVSAEEQPSDVSSTNPEDNTI
  357-  385 (49.58/37.18)	VGISLRLLLTAAHEQNLIRRSQKPPPMTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.08|      26|     317|     127|     153|       8
---------------------------------------------------------------------------
  127-  153 (40.42/32.02)	EAvPAGTLAARVLPHQT...LSTSVKRQLA
  447-  475 (39.66/26.34)	EA.PDTVLANLMLPAKTgfkISLTGGRSLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.48|      12|      19|     477|     493|       9
---------------------------------------------------------------------------
  477-  493 (13.25/23.89)	GLATFlgPplfGSRYET
  499-  510 (22.23/13.24)	GFSTL..P...AARQET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02721 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GKASAPDVLDSRREDDAQAEEDEPPQKRRERLW
2) MPEPNSISLLIPPEPTSRSQDLQTQIQRITAQR
50
1
82
33










Molecular Recognition Features






MoRF SequenceStartStop




1) SISLLIPP
6
13