<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02717

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMERLNQIDQSEHFPSDTFFDQNSLQQIQQIDPTAADLTSVPNPAVIEQLTRRWYCGCLERTAWSRHGHIATISDDASTVYVECLRFDHDSKTWCLNGRHALTTLFEDATSLAWSSTGGELAVVDVKGRIWIYHNSLIAVNRLNLARQGALDEADELSQPVGMAWLNQDRQERPRNVVLNAAKTESRWVHHNARAKPLGPYWHRAVVIVHRNGLLTLCFQRGDGQYSKVTRQLCPSDNSLYSHASFAPTVEGKMLVVLHSFKALISVYFVSIDWTEVKQAVEGLPVLTVECVSSRVASQPSGSSTLGDVYDPDSWSLSHLEVVQTSDVEKAVQIPPTILAVSSGVNRAINISDSGFLASSMIKRWTVASVEQKLHPLFDELPSKGPSTTPSSFYTLQLRPDKEEQVITTIHHVDGNPVLVVTMQDNRTDFLSSEDLSLVSYTGSATETSSMSQSGFAFPYSTNTFNPSFSPNACVRVEFSSDGKTQLASMEYQLGQEQSQQPLDPSLDMAVAALNLAFARACWSNATIDDVLMCALHTVPSETIPTVVSSMYRTLFRDTEFVNEKTPGSESERIYHKPVVGKVLAYHAGLAAYCRQLPSMASTEGRNGWSLSAQWAWLANNIRQTATLLFMNLRDVQNLNLVMNQDFTDILCSNLRWGLSVIRYIFGTILEVGDRETNPEMFDEKDHGRAGDVRGDGTQGLVALLLNIHCSRIFLIAFVRAVRMYAKTEPKSRHQVQVLQCIQQHTTGKGISFAAIEAILECRWAAQGDVEGDPATTAARQLDMMATGIVHESYQGTIKMLLSKLFNIPGGLRAKMLIDRLKLFTDCIDLEHVFLNNDVLGHRNDETKQASTIYDIHRKRPILKGIPEPNGSGELMIRKCVRCGSYSEDMSIPPREWPRQVGTLLARCVCDGNWIIEPWARSRN
Length923
PositionTail
OrganismRhinocladiella mackenziei CBS 650.93
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Rhinocladiella.
Aromaticity0.08
Grand average of hydropathy-0.224
Instability index45.74
Isoelectric point5.95
Molecular weight102929.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02717
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.36|      38|     131|     280|     317|       1
---------------------------------------------------------------------------
  280-  317 (68.65/43.93)	VEGLPVLTVECVSSR...VASQP.SGSSTLGDVYDPDSWSLS
  412-  453 (53.71/32.75)	VDGNPVLVVTMQDNRtdfLSSEDlSLVSYTGSATETSSMSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.96|      26|     137|       2|      53|       4
---------------------------------------------------------------------------
   24-   53 (37.63/70.41)	LQQIQQiDPTAADLTSVPNPAVIEQltrRW
  738-  763 (48.33/21.10)	LQCIQQ.HTTGKGISFAAIEAILEC...RW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.89|      39|      94|     672|     715|       9
---------------------------------------------------------------------------
  672-  715 (58.88/52.97)	GDRETNPEMFDEK..DHGRAGDVRgDGTQGLVALLLnihcSRIFLI
  767-  807 (64.01/40.76)	GDVEGDPATTAARqlDMMATGIVH.ESYQGTIKMLL....SKLFNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02717 with Med16 domain of Kingdom Fungi
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