<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02703

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDQDQPDDFASESFFDQNSLQQQIQQIDANANLNNVPNVAIPPNPAVLDKLSRRWYCGCLERTAWSRHGHLASISDDGSIVYLECIRYNYELKSWGLHERHSLTTLFEDATSLAWSPNGGELAVVDVKGRIWIYHNSLLAINRLTLARQGALDEGDEYSQPVGMTWLNQDRQERPRNVVTHAFKGESRWQHANARAKPLGPYWHRAVAIVHRNGLFTLCFQRSDGQYSKVTKRLSPPDDILYSHASFAPTVEGKMLITLHSFKKTISVYFLSIDWNEVKQSVEGLPILNLESVSSNVSSQPSGSPTLPDTYDPDSWLLSHLEIVRTSDVEKAVQIPPTILAISSGVNRTVNIPDSGFLVSSMIKRWTVAPVEQKLHPLFDALPSIGPGTAAPKPSYTLQRLPDKEEQVITTIHHVDGVQALVVTTQENRTDFLSSEDLSPMSYAGLAQETTSMSQSGFAYPYAQVILTPTFSPNACVRADLTPEGKTQLVAMEYQLGQPQSLQPLDPNVDVALASLNLTFARACWSNATIDDILMCVSQSIPTELIPTVISTAYRTLFRDNDFVNERTEGSELEKFIHKTVIGRVLSYHASLAANCTQLPSIASTDRRHGCWSLSAQWAWLVNNIRQAATLLFMAMRDVQNIQLVMSQDLTDLLCSNLRWGLSLMRFIISTILEVGDRETNPEMFDEKDPGRAGDSLGDGSQGLVALLLNCHPSRIFLIAFVRAVRAYAKNTEPKSNHHLQVLQCIQQQTSGKGLSFQAMEALLEYRWSAVGDVDRDMAATAARQLEMMATGIVHESYQGTIKVLLNTLFNSAQGLRAKMLIDRVKLFIDHVDLEYIFLNNDILGRRSTDEDPDRKEIIYDVHRKRPILKGVAEPGGTGQLMIRKCLRCGSYSEDVVNVPPREWPRQVAMLLMRCVCDGSWVLKPWDKVHK
Length931
PositionTail
OrganismFonsecaea pedrosoi CBS 271.37
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Fonsecaea.
Aromaticity0.08
Grand average of hydropathy-0.237
Instability index44.78
Isoelectric point5.95
Molecular weight104255.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02703
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.15|      21|     562|      31|      64|       3
---------------------------------------------------------------------------
   40-   60 (43.50/41.30)	AIPPNP...AVLDKLSRRW.YCGCL
  114-  138 (32.64/ 7.19)	AWSPNGgelAVVDVKGRIWiYHNSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     301.43|      97|     291|     454|     567|       4
---------------------------------------------------------------------------
  454-  567 (140.19/135.39)	SQSGFAYPYAQVILTPTFSPNACVRADLTPEGKTQLVAMEYQLGQpQSLQpldPNVDVALASLnLTFARACWSNATIDDILMCVSQsIPTELIptvistayrtlFRDNDFVNER
  751-  847 (161.24/108.02)	SGKGLSFQAMEALLEYRWSAVGDVDRDMAATAARQLEMMATGIVH.ESYQ...GTIKVLLNTL.FNSAQGLRAKMLIDRVKLFIDH.VDLEYI...........FLNNDILGRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02703 with Med16 domain of Kingdom Fungi
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