<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02699

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGERPTVNGAHTSNGIHQSATDSPASPNPLKPGSLPQSLPPPPPPLSIDREENEDAGSSQRRNGGADHNVASSQNQAPAEILSLISQDSYLPMAALISRASQMCWNDLSDLVEQLASLSVPDTPPDQAKLMPNGLTNNQSKPNLDKKDKIFRFANEQKADFIKLLVLLQWSKNVDEVSKTISINYWLMLRRQAYWGAIASMASLKQESSNFQIPNPDLKTAAEVLSRGRVSNFPQLGYSAQVDLSTKQILRVLKSLNQALSVKLALSDNLPSQLRNFRVHDGRATFTVPDEFELDLSTLDESLDSPFRMVDFRLSFQPCPHLPDRLQSEIELLANSNIDQGGLGRCYEFLHELTLSYKLAEFHKQAIELSRNQWVGNLRAELIRRNLVVQYWSERHVGKSWVEIGIASGRDKQRPEDPEPHSSLEIKCTWHGKRADCLQLHLNESVLSFEGILRQVIAQHSTQILDTIYDKLVSTPLFANAELSLEQSLSHDDPEVCSLVMQTSRSSQLQLKVDSVTGLIMMSPVTERTERLQFEVNRVQSVADEVVSKLLNFRCSVSESAVLAGISGTKWEALRSFKFTQAEVKSLFGRPVVRINMFRQSQWVLEYSLAVTHGQDGDHWWLLQQVSVGASDAQARYKVLRSQRIEVKEDLSSAYFDRLADYSMGLICLQRNADFFTEKKEKFDLRPFPPFGRHYELPELSFDLDMAKPLPSRQSVPTSATEGPFTIQKASDLQAKNATLQRNIQVRFGGVDHSGLRVMTVAQYQSQASSDVLRHLDKSVLDAGVSLNREDRMVTIRVETAMAEAAIPQIVAKVLDLEKVVSTVDQIHCLLGLKLKKISNATISLVYHQEHPAEFGLNIIFPSGSPAPRLEFFPPQANPHQILSQVYTKTFAANRAPFATTMRNLLTSLTATLPLLTILHSLQQRHGITSKEDQRLPSAEPEDPLRMHVLARTETQFAVQYFTPAGQVPNDSKNDSLPQLLARFEVLSEANHSGKTGWLVRPALDEFQSYSRPSYSSPELAAKVKQEIFSQRTERQCKWFLLDKGAWCTVDRPEPLINALHDVVWNWAKQAKMAVGNGVGKQDSNKGKGAQANQNVNNPNMANGTTNRGPAAAKGPPGRQQAANNAVSNGANMKLQRPPLNGPGGRPAPGNAKMNARNSQGQDVITLD
Length1169
PositionTail
OrganismPhialophora americana
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
Aromaticity0.07
Grand average of hydropathy-0.425
Instability index48.96
Isoelectric point7.65
Molecular weight130076.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02699
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.12|      16|      17|     684|     699|       1
---------------------------------------------------------------------------
  684-  699 (32.71/21.23)	FDLRPFPPFGRHYELP
  703-  718 (29.40/18.21)	FDLDMAKPLPSRQSVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     214.95|      72|     186|     108|     191|       2
---------------------------------------------------------------------------
  108-  187 (116.26/96.31)	DLSDLVEQLAS........LSVPDTPPdqaklMPNGLtnnQSKPNLDKKDKI........FRFANE.....QKADFIKLLVLL...QWSKNV..DEVSKTISINYW
  296-  393 (98.68/57.31)	DLSTLDESLDSpfrmvdfrLSFQPCPH.....LPDRL...QSEIELLANSNIdqgglgrcYEFLHEltlsyKLAEFHKQAIELsrnQWVGNLraELIRRNLVVQYW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.89|      52|     186|     399|     488|       3
---------------------------------------------------------------------------
  421-  476 (81.00/74.98)	PHSSLEI.KCTWHGKRA..DCLQlHLNESVLSfEGI.LRQ................VIAQHSTQILDtiYDKLVST
  753-  824 (62.89/26.02)	DHSGLRVmTVAQYQSQAssDVLR.HLDKSVLD.AGVsLNRedrmvtirvetamaeaAIPQIVAKVLD..LEKVVST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.26|      50|     140|     970|    1027|       4
---------------------------------------------------------------------------
  970- 1026 (72.29/47.64)	PNDSKNDslPqllARFEVLSEANHSGKTGWLVRPALDefQSYSRPSYSSPELAAKVK
 1111- 1160 (88.97/41.46)	PAAAKGP..P...GRQQAANNAVSNGANMKLQRPPLN..GPGGRPAPGNAKMNARNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.74|      13|     216|     399|     414|       7
---------------------------------------------------------------------------
  399-  414 (16.14/21.44)	GKSW.....VEIGiASgrDKQ
  618-  635 (19.60/11.21)	GDHWwllqqVSVG.AS..DAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02699 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AVGNGVGKQDSNKGKGAQANQNVNNPNMANGTTNRGPAAAKGPPGRQQAANNAVSNGANMKLQRPPLNGPGGRPAPGNAKMNARNSQGQDVITLD
2) MNGERPTVNGAHTSNGIHQSATDSPASPNPLKPGSLPQSLPPPPPPLSIDREENEDAGSSQRRNGGADHNVASSQNQAPA
1075
1
1169
80










Molecular Recognition Features






MoRF SequenceStartStop




NANANA