<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02690

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMPVSKWTTIARQCLHRRLSVQQFGHLLQAHHGEIGVRSLFDALVDCRESFCPPGDPLISLYIYHLGSTGAISVSDALLVLTKRWNDAKGQLSQDALTCYNQTLQDLTMIMISPKYKLEVSEARLALSISSRWLSALARQASREDAERTGLEYSDAVESLAFFVASLAATDPGLEVLSPSVATKKDGLDGSVKEMRASMRQALEQCLPLYSVLSSQLMERINTVLKHISLLDNGLPQDGNTSTQASEIQALQFQVSIAQSQLLASKAGGILFLGALLLTSSTIDDGTAVNWLSSRHHNDYQAMFSDIFTASFTILRCQSSTPRRSLCMQQCQVFIQNKLPALLSMISATSFNSFSTEQTITDAWHQIMPLLSEHDLLSVGAHFLHVCSLLHLLPGQMVSQLVSNENLLKGLSKGLYTKDGLVDQVNSNHARGPKLVEELIRGDGSAGFISQAIVEIMHNYCQNKETQYLKDLANAIIRKPAAINCIALFIRPSFFLGPLCSLLDEWRWDEIHGEAQPVYDDFGAVFLLILVTRARLGLSNSELGIRKKDGFLSEYLKHETYEHSLDDLSEEKKSHLGNWINALYLAEGLSDELFTTCSPHDFYLLIPTLLRQSITAYQQGKLTHDSLKAGLDYLLEPFLLPSLISALGWAAEVYQQDSVVVGKVLEVLTKAPGTMESRDIHHTILTMCAPRLKLRLVSSAAKDSNIDPVLKTLDKCQDFTLSAEREIQNESPGVVSLLQHSLATLITSTDTMHLEPPVGLNDIPALISRTVEVRGAEVALRALIEVLLQLSDSHHFPFALDAVTTAICMGGEGLHDALLLLYHNLGGMLRSGDTLAAEAVVRLYRQVEAYKNLLTVQDMGLDTIFGQQLTNIDTANPNLDAATAASGVVDMQAEQGQPDGIDQVLDEVAAMGNLDASDADMNFDSLYGLQGNEMDLNDLDLDMF
Length943
PositionTail
OrganismPhialophora americana
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Phialophora.
Aromaticity0.06
Grand average of hydropathy0.017
Instability index38.63
Isoelectric point5.03
Molecular weight103614.09
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02690
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.66|      14|      29|     602|     615|       1
---------------------------------------------------------------------------
  602-  615 (25.04/15.81)	YLLIPTLLRQSITA
  632-  645 (25.62/16.35)	YLLEPFLLPSLISA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.76|      14|      32|      30|      43|       2
---------------------------------------------------------------------------
   30-   43 (26.28/13.56)	HHGEIGVRSLFDAL
   64-   77 (24.48/12.22)	HLGSTGAISVSDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      47.92|      10|      32|     874|     883|       3
---------------------------------------------------------------------------
  874-  883 (17.34/10.66)	ANPNLDAATA
  900-  908 (13.14/ 6.21)	IDQVLD.EVA
  909-  918 (17.44/10.77)	AMGNLDASDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     284.55|      93|     361|     305|     409|       4
---------------------------------------------------------------------------
  305-  409 (141.02/134.85)	DIFtasFTILR.CqssTPRRSLCMQQCQVFIQNKLPALLSMISATSFnSFSTEQTITDAWHQIMPLLsEHDLlsvgAHFLHVCSLLHLLP..G.QMVSQLVSNENLLKG
  678-  774 (143.53/102.03)	DIH...HTILTmC...APRLKLRLVSSAAKDSNIDPVLKTLDKCQDF.TLSAEREIQNESPGVVSLL.QHSL....ATLITSTDTMHLEPpvGlNDIPALISRTVEVRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     406.92|     139|     361|      83|     237|       5
---------------------------------------------------------------------------
   83-  237 (201.07/153.24)	RWNDAKGQLSQDALT.....CYN...QTLQDLTMIMISPKYKLEVsearLALSI.SSRWLSALARQAS..REDaERTGlEYSDAVESL.AFFVASLaATDPGLEVLSPSVATKKDglDGSVKEMRAsmRQALEQCL.PLYSVLSSQLMERINTVlkhisLLDNGL.........PQD
  440-  600 (205.85/118.33)	RGDGSAGFISQAIVEimhnyCQNketQYLKDLANAIIRKPAAINC....IALFIrPSFFLGPLCSLLDewRWD.EIHG.EAQPVYDDFgAVFLLIL.VTRARLGLSNSELGIRKK..DGFLSEYLK..HETYEHSLdDLSEEKKSHLGNWINAL.....YLAEGLsdelfttcsPHD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.73|      14|      27|     821|     834|       6
---------------------------------------------------------------------------
  821-  834 (26.67/16.41)	YHNLGGMLRSG.DTL
  849-  863 (21.07/11.43)	YKNLLTVQDMGlDTI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02690 with Med5 domain of Kingdom Fungi
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