Description | Mediator of RNA polymerase II transcription subunit 8 |
Sequence | MATLSPDEVRSLDQARQRLLALHTSLIALRSDIAAQSQLPSWPALQTHANLISNNLQTIVAQLSEHRDTFQSTVAYPLPQFPAKERHFILETLLRTKLEPNVEDWVEEGENISARQHKSAQQGLSDEDRNSLWRWAPGAANKEARRQKWGADFTLEEKQHGIEDVITGLRRALVEPPDEEGDEEQEEEEEEYEVTDDEDEDKMEVEQAKPESIPQQAAGEIPPATLTVNQMPFQTIHKFMTTGR |
Length | 244 |
Position | Head |
Organism | Rhinocladiella mackenziei CBS 650.93 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Rhinocladiella. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.819 |
Instability index | 74.34 |
Isoelectric point | 4.61 |
Molecular weight | 27753.31 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364144 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02678 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.58| 20| 73| 92| 111| 2 --------------------------------------------------------------------------- 92- 111 (36.60/22.05) TLLRTKL.EPNVEDWVEEGEN 167- 187 (31.98/18.41) TGLRRALvEPPDEEGDEEQEE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.31| 10| 37| 39| 48| 3 --------------------------------------------------------------------------- 39- 48 (21.15/13.73) LPSWPALQTH 78- 87 (20.16/12.75) LPQFPAKERH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) RNSLWRWAP 2) VEQAK | 129 205 | 137 209 |
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