<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02676

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSYTSRPTAIPPSPTSPPDSGLKRRRFSDNLPQSPISPSLMSVATKSYVPPYGHNQHTDEVSGRSSPRSPTSAASHSQPSSSQITHSLPTPAHSVTGIPGLDMAEDADQHRDKRPRLDTEKDEDRMKVEPFPRATNHDRHDDMDLDAGGDADAQVAKPAGGSVADETTLEQLQEDMGEAFLSCRSKVERQRPNPQQHLLASYGLGPLLRSVARTDPRTGEKINKLRKSYEGQIKNFALAGRNKPVKGERNIEEDQPGPLRRMAGSSAWGLQPEEQWNAEHAKSKIEVTTDFRAKLQKAMQMQPGTVRNNAHWEDVLGFDKPKPNVLPPQQKAHQPTPMHVTNGIPRQPAQQTTDAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGGQRKRKKDLIGTPVAYGQYQER
Length412
PositionHead
OrganismExophiala xenobiotica
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.05
Grand average of hydropathy-1.133
Instability index61.37
Isoelectric point8.39
Molecular weight45575.85
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02676
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      19|      25|     184|     208|       1
---------------------------------------------------------------------------
  184-  203 (31.77/30.52)	RSkVERQRPNPQQ...HLLASY.G
  209-  231 (24.86/ 7.72)	RS.VARTDPRTGEkinKLRKSYeG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.95|      16|      16|     101|     116|       2
---------------------------------------------------------------------------
   99-  114 (28.79/14.58)	PGLDMAEDADQHR.DKR
  115-  131 (23.17/10.46)	PRLDTEKDEDRMKvEPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.96|      14|      16|      43|      57|       3
---------------------------------------------------------------------------
   43-   57 (22.76/15.79)	VATKSyVP..PYGHNQH
   61-   76 (20.20/ 8.61)	VSGRS.SPrsPTSAASH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      18|     245|      79|      98|       4
---------------------------------------------------------------------------
   79-   98 (26.08/23.16)	PsSSQITHSlPTPAHSVTGI
  327-  344 (37.42/22.67)	P.PQQKAHQ.PTPMHVTNGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.06|      14|      28|     267|     280|       5
---------------------------------------------------------------------------
  267-  280 (28.53/18.24)	AWGLQPEEQWNAEH
  298-  311 (26.53/16.47)	AMQMQPGTVRNNAH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02676 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSYTSRPTAIPPSPTSPPDSGLKRRRFSDNLPQSPISPSLMSVATKSYVPPYGHNQHTDEVSGRSSPRSPTSAASHSQPSSSQITHSLPTPAHSVTGIPGLDMAEDADQHRDKRPRLDTEKDEDRMKVEPFPRATNHDRHDDMDLDAGGDADAQVAKPAGGSVADETTLEQLQEDMGEAFLSCRSKVERQRPNPQQHLLASYGLGPLLRSVARTDPRTGEKINKLR
2) NFALAGRNKPVKGERNIEEDQPGPLRRMAGSSAWGLQPEEQWNAEHAKSKIEVTTDFRAKLQKAMQMQPGTVRNNAHWEDVLGFDKPKPNVLPPQQKAHQPTPMHVTNGIPRQPAQQTTDAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGGQRKRKKDLIGTPVAYGQYQER
1
235
226
412










Molecular Recognition Features






MoRF SequenceStartStop




1) EYGGQRKRKKDLIGTPVAYGQYQER
2) FVGYGEGYS
3) LMSVATKSYVP
4) LRKSY
5) MSYTSRPTAIP
6) PDSGLKRRRFSDNLP
388
371
40
225
1
18
412
379
50
229
11
32