<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02673

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAVTESQKLVRYCLLRRMSLEEFATLLETYQDEIDGQQLFSALLDCRLSFCAPGDPLISLYLEHIGTSGIVSASAALLVLISKWNSAKPVNTPAALHCYNQTLQDIIMVMVSPKYKVISSEAQKSLLLSSRWLASLARQVSHHMDDTPIADKLHVLEALAFLVVSMAATDGGYEALSLSNDSRTKSSKDSNSVQDLRTSVRQSLELCLPLYSTISTHLIGRINTVLSVLNQNISQPGDSSAQLTDIQTLDFQANIPETHMVASRAATILYLDVMLSTGSTIDDGALVNYLCSRHQNDYAAVFMDLFIASFQMLKVQSFNREPSLSYQQTRIFLQNKLPNLLSMVSASSFHGFDTEQTITDAWGQVVPQLSTKELLLIGSRFLNTCSLHHLITHTASLQLLGNEDVVSGMSKGLYTKDDLISQVVANHARGPKLVEELVRSDGSAGFISQAVVEIMHNYCHSKETQYLKDLANAIIRRPVAINCISLFVPPSFWLGPLCTLLDEWHWSEIHGEAQPLYDEFGAAFLLILVCKTRLGLAKTELGIRKKDGFLAEYFSNADSEKGLETLSEEKTTHLGNWINALYLAEGLSDELCTNCSPHDFYILIPTLLRQSMIAYQQDKLTHESLKAGLDYLLEPFLLPSLASALNWIGDVLQDDSSAAATILDVFMKAPGTPESRDIHGTILSMSASKLGKRIKSVQLHDDGKFKSVAELVKHSPDFSFSPEHGIVAEHDQLSSALQQSIVVMITTGGTFSSQEQAMSTRIPSMVYRAIHTIGAQGTLKLLLGVLIQLSDSHDFLFALDTVSTIVCTAGCGLRDALRVQHQNLGAVLKRKDSLSAEAVVRLHRQVEVYTNLLTVQDMHLNAFAFAQQLSNIDTADPNLDGVPASAGVVDMQGDQEQADGIDQVLDEVAAMGNLDANDADMNFDALYGLQGSDMDLNDLDLDMF
Length944
PositionTail
OrganismExophiala xenobiotica
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy0.033
Instability index39.80
Isoelectric point5.00
Molecular weight103646.91
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02673
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.88|      42|      45|     664|     707|       1
---------------------------------------------------------------------------
  664-  707 (63.18/59.33)	DVFMKAPGTPESRDiHGTILSMS..ASKLGKRIkSVQLHDDGKFKS
  710-  753 (66.70/51.64)	ELVKHSPDFSFSPE.HGIVAEHDqlSSALQQSI.VVMITTGGTFSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.47|      33|      36|     316|     350|       2
---------------------------------------------------------------------------
  318-  350 (55.48/39.49)	FNREPSLSYQQTRIFLQNKLPNLL....SMVSASSFH
  352-  388 (50.99/29.35)	FDTEQTITDAWGQVVPQLSTKELLligsRFLNTCSLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.50|      33|      45|     186|     226|       3
---------------------------------------------------------------------------
  186-  226 (41.11/49.10)	SSKDSNSVQdlRTSVrQSLEL..CLPlystiSTHLI.GRINTVL
  234-  269 (48.39/31.07)	SQPGDSSAQ..LTDI.QTLDFqaNIP.....ETHMVaSRAATIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.30|      15|      45|      70|      84|       4
---------------------------------------------------------------------------
   70-   84 (24.47/13.70)	IVSASA.ALLVLISKW
  117-  132 (20.82/10.61)	VISSEAqKSLLLSSRW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.75|      32|      39|     869|     906|       6
---------------------------------------------------------------------------
  869-  906 (41.60/40.25)	LSNIDTADPNLDgVPASAGvvdMQGDQEQADGIDqvLD
  911-  942 (57.15/33.52)	MGNLDANDADMN.FDALYG...LQGSDMDLNDLD..LD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      24|      31|     601|     624|       7
---------------------------------------------------------------------------
  601-  624 (42.45/24.22)	YILIPTLLR..QSMIAYQQDKLTHES
  631-  656 (38.46/21.34)	YLLEPFLLPslASALNWIGDVLQDDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.77|      24|     703|     136|     161|       8
---------------------------------------------------------------------------
  136-  161 (34.44/26.44)	LARQVSHHMDDTPIADkLHvLEALAF
  842-  865 (43.33/24.32)	LHRQVEVYTNLLTVQD.MH.LNAFAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.03|      33|      39|     757|     792|      10
---------------------------------------------------------------------------
  757-  792 (45.31/37.33)	AMSTrIPSMVYRAihTIGAQGTLKLL...LGVLIQLSDS
  798-  833 (49.72/29.46)	ALDT.VSTIVCTA..GCGLRDALRVQhqnLGAVLKRKDS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02673 with Med5 domain of Kingdom Fungi
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