<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02672

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMVDGMAASLEFPNNCSTNVYTLNDFGEIAYIVCTVATPPSQDPSAFVSTPESALARLQKTERQFREASILAALDVENRQLFTFYKKVDIANAKDQKALLTKFGYVLRSNTCTIAYKTAARLPDLMKPEQVRLYRLFTTAIISSIKLLPNGDSALRPFGPNLYLVQQSSSDSEVDHFTPEDLWCLHRVDLQVIPSGYIILTIVKDRRHSFRRVVDVEKDLNFKPYTSQANFPLYLAPLGRVARLVGVATDPTSKASEGGQGHQVTGSQNVDPAKELWRDILPTWLEENTSITLGSGDVTWVEAQVAVHDSEQLSTDTTGVSTPNSGKSGSVTWRTLFWPASLCFVLHHEPASLIESFGIYQDPMRFIRDWIAGTINEKPNIKRDIDMINLADDDDEPLFAENGTFDDPEHFQPFGPPAFPASQTIYPTPPDAVMTHATPGLSSVDGIAMTPANMSGKPADTARRPDVEMQDLEGLNNDSAMSGFYDEDLFEEMAEDDFGQEGTADEPNWDFFDRPGVDSKPTPAMLSNQAEGLSKQDDTSMYAFDENIGVSLPSDGREYHNSVNAEPDTLMSDQDDTRYHQSPEQIGDSDTVKAKASQQENRHPNTGKRRSSSIYERVQHPMTPSDRDYKYTANGDFWFDPNPVALKSGADAFKISTMGILTSNSSDDEISMDSRSSSKARESAERNPPMLSRQWTEYHPEPPTTANHHDEVERAAAEADIKQLLEVLKPGPTETTSIVDLQPLDTITGIDQLPGQKFLQIAHILVDQISQTSLIPHAEKDEHRNLSDDNLEIVADLRGMNSSANASTLSQLVSLKTDYNTVKLQGKLFKLHPNQIGLKRADQPLIASMSIMAFWDSLSLQPAHGPKNVTAFCIHRDTEDVADGCTNLLLRMSDTYNTCAFGSHTIGRLSGVANDGMMAWSSTESAQLDLHHACQTMGTAIGAVTNLTGTVLVYMISDSDSPASYLEICQAFNGLFESFVARADKKHVTDIALQIVPRSFIASPESLIVPPQAAYLKLAIEVYNRLPPADPGGSAAACDTAVVLSKAENPVHLQLASIYASPLSRNGECLHLAYSASVDGRWITAAWTDDLGHLSLAMSYCARRRDSTRIRPRQEILKEMWQVSHDLMSKTQGLWRLGVIKQGYYTLKELQDWRQIFESSTTSQKRCLPMLLSAQLDPKLRVFTHMASGKPAQPSQNLYGTPVSTPQAGVTSPDQLVPATPTPGGTSMINASTPPEPGLDPNVDGDLTLVDPAEDSWGIILPYGINQSNNMVELRPALATGVLLKRRGPKLEDGCISIEVSLIYLPSHAADGSGEATPDELLDDVIRQYRGLLTLGVTRGCVDPSDECIPWHIATATRGSKALGQVM
Length1366
PositionKinase
OrganismExophiala xenobiotica
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.07
Grand average of hydropathy-0.367
Instability index43.11
Isoelectric point4.89
Molecular weight149974.51
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02672
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     210.02|      64|     270|      21|      85|       1
---------------------------------------------------------------------------
   21-   85 (104.33/65.31)	TLNDfGEIAYIVCTVATPPSQD...PSAFVSTPESALARLQKTERQFREASILAALDVENRQL...FTFYK
  291-  360 (105.68/61.77)	TLGS.GDVTWVEAQVAVHDSEQlstDTTGVSTPNSGKSGSVTWRTLFWPASLCFVLHHEPASLiesFGIYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.24|      34|      35|     515|     548|       2
---------------------------------------------------------------------------
  515-  548 (59.87/39.99)	GVDSKPTPA...MLSNQAEG...LSKQDDTSMYAFDENIG
  550-  586 (39.80/23.75)	...SLPSDGreyHNSVNAEPdtlMSDQDDTRYHQSPEQIG
  590-  614 (31.57/17.10)	TVKAKASQQ...ENRHPNTG.....KRRSSSIY.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.35|      12|      26|     692|     703|       3
---------------------------------------------------------------------------
  692-  703 (25.70/14.19)	RQWTEYHPEPPT
  721-  732 (20.65/ 9.98)	KQLLEVLKPGPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.07|      37|     530|     737|     799|       4
---------------------------------------------------------------------------
  737-  774 (56.85/88.23)	IVDLQPLDTITGIDQLPGQKF.LQIAHILVDQISQtSLI
  808-  845 (57.21/29.26)	LSQLVSLKTDYNTVKLQGKLFkLHPNQIGLKRADQ.PLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.09|      21|      28|     414|     438|       5
---------------------------------------------------------------------------
  414-  434 (43.48/16.08)	GPPAFPASQTIYPTP....PDAVMT
  445-  468 (23.92/ 8.86)	GIAMTPANMSGKPADtarrPDVEM.
 1188- 1210 (32.69/ 9.55)	GKPAQP.SQNLYGTP.vstPQAGVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.69|      20|     404|     865|     884|       6
---------------------------------------------------------------------------
  865-  884 (37.51/24.19)	PKNVTAFCIHRDTEDVADGC
 1275- 1294 (35.18/22.23)	PALATGVLLKRRGPKLEDGC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.81|      34|     981|     243|     281|       7
---------------------------------------------------------------------------
  243-  281 (57.77/51.11)	LVGVATDPtskasEGGQGHQVTGSQN.VDPAKELWRDILP
 1227- 1261 (61.04/42.02)	MINASTPP.....EPGLDPNVDGDLTlVDPAEDSWGIILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.82|      58|     782|     162|     235|       8
---------------------------------------------------------------------------
  162-  235 (71.97/90.25)	YLVqqSSSDSEVD......HFtpEDLW..CLHRVDLQVIPSgyIILTIVKdrrhsfRRVVDVEKDLNFKPytsQANFpLYLA
  953- 1018 (89.86/57.19)	YMI..SDSDSPASyleicqAF..NGLFesFVARADKKHVTD..IALQIVP......RSFIASPESLIVPP...QAAY.LKLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.95|      13|     781|     109|     121|       9
---------------------------------------------------------------------------
  109-  121 (23.63/14.85)	NTCTIAYKTAARL
  896-  908 (25.32/16.42)	NTCAFGSHTIGRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.20|      13|      25|     472|     485|      16
---------------------------------------------------------------------------
  472-  485 (20.51/14.30)	EGlNNDSAMSGFYD
  500-  512 (26.70/14.52)	EG.TADEPNWDFFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02672 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISTMGILTSNSSDDEISMDSRSSSKARESAERNPPMLSRQWTEYHPEPPTTANHHDEVERAAA
2) PAQPSQNLYGTPVSTPQAGVTSPDQLVPATPTPGGTSMINASTPPEPGLDPNVDGDL
3) PPAFPASQTIYPTPPDAVMTHATPGLSSVDGIAMTPANMSGKPADTARRPDVEMQDLEGLNNDSAMSGFYDEDLFEEMAEDDFGQEGTADEPNWDFFDRPGVDSKPTPAMLSNQAEGLSKQDDTSMYAFDENIGVSLPSDGREYHNSVNAEPDTLMSDQDDTRYHQSPEQIGDSDTVKAKASQQENRHPNTGKRRSSSIYERVQHPMTPSDRDYKYTAN
654
1190
415
716
1246
633










Molecular Recognition Features






MoRF SequenceStartStop




1) FYDEDLFEEMAEDDFGQE
2) PNWDFFDR
483
506
500
513