Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSYTSRPTAIPPSPTSPPDSGLKRRRFSDNLPQSPISPSLMSVATKSYVPPYGHNQHTDEVSGRSSPRSPTSAASHSQPSSSQITHSLPTPAHSVTGIPGLDMAEDADQHRDKRPRLDTEKDEDRMKVEPFPRATNHDRHDDMDLDAGGDADAQVAKPAGGSVADETTLEQLQEDMGEAFLSCRSKVERQRPNPQQHLLASYGLGPLLRSVARTDPRTGEKINKLRKSYEGQIKNFALAGRNKPVKGERNIEEDQPGPLRRMAGSSAWGLQPEEQWNAEHAKSKIEVTTDFRAKLQKAMQMQPGTVRNNAHWEDVLGFDKPKPNVLPPQQKAHQPTPMHVTNGIPRQPAQQTTDAKRQTRGKKRSYGDDSFVGYGEGYSDPEDGDGDEYGGQRKRKKVMTMMGS |
Length | 404 |
Position | Head |
Organism | Exophiala xenobiotica |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.111 |
Instability index | 61.68 |
Isoelectric point | 8.71 |
Molecular weight | 44621.97 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP02667 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.64| 19| 25| 184| 208| 1 --------------------------------------------------------------------------- 184- 203 (31.77/27.65) RSkVERQRPNPQQ...HLLASY.G 209- 231 (24.86/ 6.92) RS.VARTDPRTGEkinKLRKSYeG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 51.95| 16| 16| 101| 116| 2 --------------------------------------------------------------------------- 99- 114 (28.79/14.44) PGLDMAEDADQHR.DKR 115- 131 (23.17/10.42) PRLDTEKDEDRMKvEPF --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 42.96| 14| 16| 43| 57| 3 --------------------------------------------------------------------------- 43- 57 (22.76/15.08) VATKSyVP..PYGHNQH 61- 76 (20.20/ 8.23) VSGRS.SPrsPTSAASH --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 63.51| 18| 245| 79| 98| 4 --------------------------------------------------------------------------- 79- 98 (26.08/27.13) PsSSQITHSlPTPAHSVTGI 327- 344 (37.42/26.56) P.PQQKAHQ.PTPMHVTNGI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.06| 14| 28| 267| 280| 5 --------------------------------------------------------------------------- 267- 280 (28.53/16.59) AWGLQPEEQWNAEH 298- 311 (26.53/14.98) AMQMQPGTVRNNAH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DEYGGQRKRKKVMTMMG 2) FVGYGEGYS 3) LMSVATKSYVP 4) MSYTSRPTAIP 5) PDSGLKRRRFSDNLP | 387 371 40 1 18 | 403 379 50 11 32 |
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