<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP02666

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNGDRPTVNGERILNGVQHDVSNSASHIGQTKQVQDVKPLPAPVKNGSSIPVNGQHGASQIPNGDHPRSVANGFEQAPPEILDLVPKDSYLPMAALISRASQTCWNGLASMVEQLATMQVPELPLDQTKTLPNNLPNNQTKANLDKKDRLLRFANDQKADFIKLLVLLEWSKNVDDVSKTISINFWLMDRRRAYWNAISSMALLKQDSAGFQVPNPDLKVAAEVLSKGKVAKFPTLEAYLPQKDLSDKQILRLLRSLNQALSVRLALADDLPRQLRKFRVHDGRATFTVPNEFELDVSILDESVDAHFRMVDFRFRFSPAPPITDALHAEIERLANSNIDRDGLHGCYLFLHELTLSYKLAELHNQAIDLFRSQWAGHLRVEMIRRNLIIQYWTERPSSKSWIEFGIGSGRGTNHVSGQEPVPCLEIKWMRHGKKVDTLLLRLDDSVLCVEDILRQVIAQHSTQHLDSIFDKLVLTPLFASGELLVEQATSDEDPEQCSLTIQLSRGSHLQLKVDAVTGMLVISPVSERSERLQYEINRVHNVADEIVSKLLNFRCSVMEGVVLASIAGTSWETLRAFRLTQGEIKTMYGGPVVRINLVRQSQWGWGFFLAIIHAHDGDHWCLSQQIAVNGLNPHAQFQVLRTQKIHVKEELSPAYFERLADYANGLISLQRNADFVREKGEKLELAPFPAFDKHYVLPELSFELDMSKPAFAGQRHPSPGMAKSISGSVDATAVHKTIKVRFGGIDRATGRVLTIAQVQNGASQRVLKHLDKSMLDGDVTLDSQHGTLTIRVQSSISEPAISAIVDKAMDLEKSLATMEQIYRLPGLKLKTMSNPSFTITYQHDGPKELGVNINLGVGSQIPRIDFFPREVNPHIHLASQYTRLFQAPHVPFAAKVGDFLTSLILTLPLTTFLQTLQRNLGLNARPQQPDTRNPESGVRVHVLVRNATAFAVQYFTTAARVPQDVGPNSQPHLLARLEIVQHINSSDKPMWLVRAALEDFQSYTRPSYTTPALRAKLRQEIFARSENESKWLALDNAAACMADRPEALLQSIHEVLCNWAKQSTDSDAASTQSNQTQNKATKGQDNLPNGMNKPKAPGKLQMPGNAMPIGPVKQQRTPNTKGSRPVAATKGSTGTARNSEVITLD
Length1146
PositionTail
OrganismExophiala xenobiotica
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Chaetothyriomycetidae> Chaetothyriales> Herpotrichiellaceae> Exophiala.
Aromaticity0.06
Grand average of hydropathy-0.317
Instability index41.55
Isoelectric point8.66
Molecular weight127562.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP02666
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.96|      18|     149|      48|      65|       1
---------------------------------------------------------------------------
   48-   65 (34.43/21.53)	SSIPVNGQHGAS.QIPNGD
  199-  217 (28.53/16.58)	SSMALLKQDSAGfQVPNPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.59|      35|     155|     566|     605|       4
---------------------------------------------------------------------------
  566-  605 (55.05/60.08)	SIAGTSWETlrAFRLTqgeIKTMYGG...PVVRINLVRQSQWG
  725-  762 (54.55/41.97)	SISGSVDAT..AVHKT...IKVRFGGidrATGRVLTIAQVQNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.91|      15|      16|     625|     639|       6
---------------------------------------------------------------------------
  625-  639 (26.90/16.43)	QQIAVNGLNPHAQFQ
  644-  658 (26.01/15.65)	QKIHVKEELSPAYFE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.43|      49|     952|      92|     142|       7
---------------------------------------------------------------------------
   92-  142 (79.12/57.24)	PMAALISRASQTC.WnGLASMVEQLATMQVPELPLDQTKTlPNNLPN..NQTKA
 1046- 1097 (77.31/47.30)	PEALLQSIHEVLCnW.AKQSTDSDAASTQSNQTQNKATKG.QDNLPNgmNKPKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.68|      22|     552|     372|     394|       8
---------------------------------------------------------------------------
  372-  394 (37.82/35.03)	RSQWAGhLRVEMIRRN...LIIQYWT
  933-  957 (34.87/25.49)	RNPESG.VRVHVLVRNataFAVQYFT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.73|      16|     107|     871|     893|      11
---------------------------------------------------------------------------
  852-  869 (24.91/12.19)	VNINLGVGSQIPRidFFP
  872-  887 (29.82/27.72)	VNPHIHLASQYTR..LFQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP02666 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKQSTDSDAASTQSNQTQNKATKGQDNLPNGMNKPKAPGKLQMPGNAMPIGPVKQQRTPNTKGSRPVAATKGSTGTARNSEVITLD
2) MNGDRPTVNGERILNGVQHDVSNSASHIGQTKQVQDVKPLPAPVKNGSSIPVNGQHGASQIPNGDHPRSVANGFEQAP
1061
1
1146
78










Molecular Recognition Features






MoRF SequenceStartStop




1) VKQQRT
1113
1118